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    System and method for modelling of dose calculation in radiotherapy treatment planning
    4.
    发明授权
    System and method for modelling of dose calculation in radiotherapy treatment planning 有权

    公开(公告)号：US11413474B2

    公开(公告)日：2022-08-16

    申请号：US16500419

    申请日：2018-04-03

    Applicant: RaySearch Laboratories AB

    Inventor： Albin Fredriksson

    IPC: A61N5/10 ,  G16H20/40

    Abstract: A method is proposed for evaluating the robustness of a radiotherapy treatment plan. The method comprises, defining a number of scenarios, each comprising one or more errors for each fraction of the plan, including interfractional and/or intrafractional errors, and calculating a dose distribution resulting from the scenario;
    The robustness of the plan is then evaluated based at least one of the following i. the probability of fulfilling a set of clinical goals estimated as the clinical goal fulfilment over the scenarios ii. the range of DVH values over the scenarios iii. dose statistics for dose distributions defined as voxel-wise aggregates over the scenario doses.

    Method and a corresponding radiation treatment system for generating a radiation treatment plan
    5.
    发明授权
    Method and a corresponding radiation treatment system for generating a radiation treatment plan 有权

    公开(公告)号：US10850125B2

    公开(公告)日：2020-12-01

    申请号：US16731346

    申请日：2019-12-31

    Applicant: RaySearch Laboratories AB

    Inventor： Albin Fredriksson ,  Mats Holmström ,  Kjell Eriksson

    IPC: A61N5/10

    Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for generating a radiation treatment plan. According to one example embodiment, a method may comprise dividing at least one dose characteristic related to a dose distribution for a ROI into a plurality of subintervals. The method may further comprise partitioning the ROI into a plurality of different partitions based on the subintervals. All voxels of the ROI with values within the same subinterval are partitioned into the same partition. For each of the plurality of different partitions, the method may comprise establishing a weight and specifying an optimization function for an obtainable dose distribution based on the respective subinterval of dose characteristics. The method may further comprise generating the radiation treatment plan based on said established weights and specified optimization functions.

    Method and system for robust radiotherapy treatment planning for biological uncertainties
    8.
    发明授权
    Method and system for robust radiotherapy treatment planning for biological uncertainties 有权

    公开(公告)号：US12076586B2

    公开(公告)日：2024-09-03

    申请号：US17618088

    申请日：2020-06-02

    Applicant: RaySearch Laboratories AB

    Inventor： Minna Wedenberg ,  Jakob Ödén ,  Albin Fredriksson ,  Erik Traneus

    IPC: A61N5/10

    CPC classification number: A61N5/1031 ,  A61N5/1038 ,  A61N2005/1041

    Abstract: A method for generating a robust radiotherapy treatment plan for a treatment volume of a subject, the treatment volume being defined using a plurality of voxels, the method comprising the steps of defining (S100) an optimization problem using at least one optimization function for a biological endpoint related to the radiotherapy treatment; defining (S102) a set of scenarios comprising at least a first scenario and a second scenario, wherein at least two of the scenarios in the set of scenarios represent different biological models to quantify the same biological endpoint; calculating (S104) an optimization function value for each scenario in the set of scenarios; generating (S106) a radiotherapy treatment plan by robustly optimizing the optimization function value evaluated over the set of scenarios.

    System and method for passive ion radiotherapy treatment planning and delivery
    9.
    发明授权
    System and method for passive ion radiotherapy treatment planning and delivery 有权

    公开(公告)号：US11969608B2

    公开(公告)日：2024-04-30

    申请号：US17415019

    申请日：2019-12-12

    Applicant: RaySearch Laboratories AB

    Inventor： Albin Fredriksson ,  Erik Engwall ,  Kjell Eriksson ,  Erik Traneus

    IPC: A61N5/10

    CPC classification number: A61N5/1031 ,  A61N5/1078 ,  A61N2005/1087

    Abstract: A method of generating a radiotherapy plan for ion therapy, wherein the beam (6) is shaped by means of passive devices is arranged to allow variation in settings of at least one of the passive devices and/or the MU during the delivery of the beam and to control the movement of the patient and/or the beam in such a way as to create an arc. The arc is preferably a continuous arc or includes at least one continuous sub-arc. The method may include forward planning or optimization. In the latter case, the optimization uses an optimization problem set up to allow variation in settings of at least one of the range modulating device (9), the aperture element (11) and the MU during the delivery of the arc. Computer programs control the planning and the delivery.

    Evaluation of arcs for a radiation treatment plan
    10.
    发明授权
    Evaluation of arcs for a radiation treatment plan 有权

    公开(公告)号：US11607559B2

    公开(公告)日：2023-03-21

    申请号：US16646267

    申请日：2018-09-07

    Applicant: RaySearch Laboratories AB

    Inventor： Kjell Eriksson ,  Albin Fredriksson ,  Henrik Olsson

    IPC: A61N5/10

    Abstract: It is provided a method for determining arc costs. The method comprises the steps of: determining a plurality of beam orientations; evaluating a set of at least one cost function comprising an intermediate exposure cost function that is evaluated by performing the substeps of: projecting the at least one target volumes on a beam plane; determining an alignment angle based on a collimator angle value; finding any intermediate area in the beam plane along the alignment angle between areas of the at least one target volume projection; determining a value of the intermediate exposure cost function. The method further comprises the steps of: finding a plurality of arcs, wherein each arc comprises a sequence of a plurality of beam orientations; and calculating, for each arc in the plurality of arcs, at least one arc cost based on the cost function values of the beam orientations of the arc.

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