公开(公告)号：US12179038B2

公开(公告)日：2024-12-31

申请号：US17415768

申请日：2019-12-12

Applicant: RaySearch Laboratories AB

Inventor： Albin Fredriksson ,  Rasmus Bokrantz ,  Erik Engwall ,  Kjell Eriksson ,  Lars Glimelius

IPC: A61N5/10

Abstract: A method of optimizing the use of resources in treatment planning involving more than one radiation set delivered to one or more patients, the radiation sets requiring different resources, respectively, wherein the optimization is performed using an optimization problem comprising an optimization function related to the first and second sets of resources. The method may be used for optimizing one plan for one patient, or a number of plans for different patients, in such a way that the available resources are used in the best possible way.

公开(公告)号：US20220143424A1

公开(公告)日：2022-05-12

申请号：US17594307

申请日：2020-03-30

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Martin Janson

IPC: A61N5/10

Abstract: It is provided a method for generating a plurality of treatment plans for radiation therapy, each treatment plan specifying weights for a plurality of geometrically defined fluence elements. Each weight defines an amount of radiation fluence, to thereby provide radiation dose to a target volume. The method is performed in a treatment planning system and comprises the steps of: generating a first set of treatment plans; determining a subset of the fluence elements, based on the first set of treatment plans; and generating a second set of at least two treatment plans, wherein the treatment plans only contain weights for the subset of fluence elements.

公开(公告)号：US12053647B2

公开(公告)日：2024-08-06

申请号：US17056477

申请日：2019-05-24

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz

IPC: A61N5/10

CPC classification number: A61N5/1036 ,  A61N5/1047

Abstract: Automatic radiation therapy treatment planning for generating a plan to be delivered from at least one beam angle, using a collimator having a variable collimator angle. Delivery times are determined for a number of possible collimator angles, and the optimization problem is defined to take the delivery times into account when selecting the collimator angles to be used when delivering the radiation.

公开(公告)号：US11554270B2

公开(公告)日：2023-01-17

申请号：US16645169

申请日：2018-06-12

Applicant: RaySearch Laboratories AB

Inventor： Björn Andersson ,  Björn Hårdemark ,  Rasmus Bokrantz

IPC: A61N5/10 ,  G16H20/40

Abstract: It is provided a method for optimizing a treatment plan for use in radiation therapy. The method is performed in a treatment planning system and comprises the steps of: obtaining a first quality function of the treatment plan, the first quality function yielding an output value based on an input treatment plan; obtaining a first pair of input values and a slope indicator, the input values associating a value of the first quality function to a value of a score; constructing a score function that maps values of the first quality function to values of the score by fitting a curve to the first pair of input values and the slope indicator; and optimizing the treatment plan with respect to the score function, by varying the treatment plan such that the value of the score function is either improved or constrained to a feasible range of score values.

公开(公告)号：US11607560B2

公开(公告)日：2023-03-21

申请号：US17612666

申请日：2020-05-12

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Kjell Eriksson ,  Fredrik Löfman

IPC: A61N5/10

Abstract: Better Pareto dose distributions for multi-criteria optimization of treatment plans can be obtained by obtaining at least one reference dose function designed to result in an acceptable reference dose distribution, defining a multi-criteria optimization problem including the at least one reference dose function as at least one optimization function, performing at least two optimization procedures based on the multi-criteria optimization problem to generate a set of at least two possible treatment plans, obtaining a treatment plan to be used for treating the patient, based on the set of possible treatment plans, by selecting one plan or by combining plans.

公开(公告)号：US11167153B2

公开(公告)日：2021-11-09

申请号：US17058176

申请日：2019-06-10

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Kjell Eriksson ,  Tianfang Zhang

IPC: A61N5/10

Abstract: A method of obtaining an interpolated treatment plan is based on interpolating between associated dose distributions through optimization with respect to an optimization problem comprising optimization functions based on deviations from clinical goals. The method may suitably be used to improve navigated plans resulting from multi-criteria optimization.

公开(公告)号：US10441812B2

公开(公告)日：2019-10-15

申请号：US15367872

申请日：2016-12-02

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Björn Hårdemark

IPC: A61N5/10

Abstract: An output radiation treatment plan for at least one target in a treatment volume is determined. Each target is associated with a prescribed radiation dose. An updated treatment plan causes the prescribed radiation dose to be delivered to the target when implemented by a radiation therapy machine. The updated treatment plan requires an updated delivery time to complete and is calculated by: [i] receiving a numerical value designating an upper bound on modulation efficiency of the updated treatment plan, [ii] receiving a current treatment plan, [iii] calculating a current delivery time for the current treatment plan, [iv] calculating an un-modulated delivery time for the current treatment plan, and [v] calculating the updated treatment plan by executing an optimization process while satisfying the upper bound on the modulation efficiency. Steps [ii] to [v] are traversed a predetermined number of times. Thereafter, the output radiation treatment plan is generated.

公开(公告)号：US11992704B2

公开(公告)日：2024-05-28

申请号：US17596506

申请日：2020-06-02

Applicant: RaySearch Laboratories AB

Inventor： Bjorn Andersson ,  Cecilia Battinelli ,  Rasmus Bokrantz

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N2005/1087

Abstract: A method of radiotherapy treatment planning for particle-based arc treatment comprises the steps of



determining (S11; S21) an initial set of candidate energy layers,
performing a calculation on the initial set,
determining (S13; S23), based on the outcome of said calculation, at least one additional energy layer to produce an expanded candidate layer set, wherein the at least one additional energy layer involves an energy level that has not previously been used
adding (S14; S24) the at least one additional energy to the initial set, to produce an expanded candidate energy layer set
optimizing (S16; S26) a radiotherapy treatment plan based on the expanded candidate layer set.

公开(公告)号：US11865363B2

公开(公告)日：2024-01-09

申请号：US17057170

申请日：2019-05-27

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Albin Fredriksson ,  Kjell Eriksson ,  Erik Engwall ,  Erik Traneus

IPC: A61N5/10

CPC classification number: A61N5/1031 ,  A61N2005/1089 ,  A61N2005/1091

Abstract: The present disclosure generally relates to the field of radiation treatment. More specifically, the present disclosure generally relates to methods and radiation treatment systems for facilitating a multimodal radiation therapy treatment plan, in particular a multimodal radiation therapy plan employing a combined photon beam and electron beam radiation treatment. According to one example embodiment described in the disclosure, a method may comprise obtaining information related to a set of candidate beam types for the combined photon beam and electron beam radiation treatment; comparing the set of candidate beam types against a selection criterion to establish a subset of beam types from the candidate beam types; and generating the combined photon beam and electron beam radiation treatment plan utilizing the thus established subset of beam types.

公开(公告)号：US11027148B2

公开(公告)日：2021-06-08

申请号：US16481150

申请日：2017-01-27

Applicant: RaySearch Laboratories AB

Inventor： Rasmus Bokrantz ,  Albin Fredriksson

IPC: A61N5/10

Abstract: A system plans a radiation therapy treatment of a target volume based on inputs in the form of: a set of candidate beams (B), where each beam defines an arrangement of a therapeutic beam relative to the target volume; a treatment plan (x) for the radiation therapy treatment that uses a subset of the candidate beams (B); an objective function (F) describing a quality of the treatment plan (x); and a feasible region (X) describing requirements on the treatment plan (x) that must be fulfilled. The objective function (F) and/or the feasible region (X) also reflect a first complexity criterion (τ(x)≤{circumflex over (τ)}) limiting a first complexity measure (τ(x)) to be less than or equal to a maximum first complexity ({circumflex over (τ)}). An optimization step is executed repeatedly; whereby, in each iteration, an updated treatment plan (x′) is calculated by optimizing the treatment plan (x) with respect to the objective function (F) and the feasible region (X). Here, if a termination criterion is fulfilled, a set of selected beams (B*) is calculated based on the updated treatment plan (x′). The set of selected beams (B*) is a subset of the set of candidate beams (B). Otherwise, the updated treatment plan (x′) is set to the treatment plan (x); an updated first complexity criterion (τ′(x)≤{circumflex over (τ)}′) is calculated; the updated first complexity criterion (τ′(x)≤{circumflex over (τ)}′) is set to the first complexity criterion (τ(x)≤{circumflex over (τ)}), and another iteration of the optimization step is executed.