公开(公告)号：US11454584B2

公开(公告)日：2022-09-27

申请号：US16992266

申请日：2020-08-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/39 ,  G01N21/05 ,  G01N21/03 ,  G01N21/3577 ,  G01N21/85 ,  G01N15/02 ,  G01N21/53

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US10190969B2

公开(公告)日：2019-01-29

申请号：US15454033

申请日：2017-03-09

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/35 ,  G01N21/39 ,  G01N21/85 ,  B01L3/00 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/45 ,  G01N21/01 ,  G01N21/552

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US09778167B2

公开(公告)日：2017-10-03

申请号：US15175709

申请日：2016-06-07

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAllister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/00 ,  G01N15/14 ,  G01N21/39 ,  G01N21/05 ,  G01N21/03 ,  G01N21/3577 ,  G01N21/85 ,  G01N15/02 ,  G01N21/53

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1404 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/532 ,  G01N21/85 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/10

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US11169084B2

公开(公告)日：2021-11-09

申请号：US16257112

申请日：2019-01-25

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/35 ,  G01N21/85 ,  B01L3/00 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/45 ,  G01N21/39 ,  G01N21/552 ,  G01N21/01

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US10746646B2

公开(公告)日：2020-08-18

申请号：US16218875

申请日：2018-12-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/00 ,  G01N15/14 ,  G01N21/39 ,  G01N21/05 ,  G01N21/03 ,  G01N21/3577 ,  G01N21/85 ,  G01N15/02 ,  G01N21/53

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US20190226983A1

公开(公告)日：2019-07-25

申请号：US16257112

申请日：2019-01-25

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/39 ,  G01N21/85 ,  G01N21/05 ,  G01N21/27 ,  G01N21/3577 ,  B01L3/00 ,  G01N21/35 ,  G01N21/45

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US20190113436A1

公开(公告)日：2019-04-18

申请号：US16218875

申请日：2018-12-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAllister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/85 ,  G01N21/05 ,  G01N21/03 ,  G01N15/02 ,  G01N21/53 ,  G01N21/39 ,  G01N21/3577

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1404 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/532 ,  G01N21/85 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/10

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US20180024041A1

公开(公告)日：2018-01-25

申请号：US15714035

申请日：2017-09-25

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAllister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N21/85 ,  G01N21/03 ,  G01N15/02 ,  G01N21/3577 ,  G01N21/05 ,  G01N21/39 ,  G01N21/53

CPC classification number: G01N15/1436 ,  G01N15/0205 ,  G01N15/1404 ,  G01N15/1484 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/532 ,  G01N21/85 ,  G01N2021/399 ,  G01N2201/0612 ,  G01N2201/10

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.

公开(公告)号：US20170184490A1

公开(公告)日：2017-06-29

申请号：US15454033

申请日：2017-03-09

Applicant: Redshift Bioanalytics, Inc.

Inventor： Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N21/17 ,  G01N21/85 ,  G01N21/35

CPC classification number: G01N21/1717 ,  B01L3/502761 ,  B01L2200/0652 ,  B01L2400/0439 ,  G01N21/05 ,  G01N21/274 ,  G01N21/35 ,  G01N21/3577 ,  G01N21/39 ,  G01N21/45 ,  G01N21/552 ,  G01N21/85 ,  G01N2021/0168 ,  G01N2021/1723 ,  G01N2021/399

Abstract: A fluid analyzer includes an optical source and an optical detector defining an optical beam path through an interrogation region of a fluid flow cell. Flow-control devices conduct analyte and reference fluids through a channel and the interrogation region, and manipulate fluid flow in response to control signals to move a fluid boundary separating the analyte and reference fluids across the interrogation region. A controller generates control signals to (1) cause the fluid boundary to be moved across the interrogation region accordingly, (2) sample an output signal from the optical detector at a first interval during which the interrogation region contains more analyte fluid than reference fluid and at a second interval during which the interrogation region contains more reference fluid than analyte fluid, and (3) determine from samples of the output signal a measurement value indicative of an optically measured characteristic of the analyte fluid.

公开(公告)号：US20200371014A1

公开(公告)日：2020-11-26

申请号：US16992266

申请日：2020-08-13

Applicant: Redshift Bioanalytics, Inc.

Inventor： Matthias Wagner ,  Charles McAlister Marshall ,  Donald Kuehl ,  Jeffrey Guasto

IPC: G01N15/14 ,  G01N15/02 ,  G01N21/03 ,  G01N21/05 ,  G01N21/39 ,  G01N21/53 ,  G01N21/85 ,  G01N21/3577

Abstract: A fluid analyzer includes an optical source and detector defining a beam path of an optical beam, and a fluid flow cell on the beam path defining an interrogation region in a fluid channel in which the optical beam interacts with fluids. One or more flow-control devices conduct a particle in a fluid through the fluid channel. A motion system moves the interrogation region relative to the fluid channel in response to a motion signal, and a controller (1) generates the motion signal having a time-varying characteristic, (2) samples an output signal from the optical detector at respective intervals of the motion signal during which the interrogation region contains and does not contain the particle, and (3) determines from output signal samples a measurement value indicative of an optically measured characteristic of the particle.