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公开(公告)号：US20230258680A1
公开(公告)日：2023-08-17
申请号：US18137254
申请日：2023-04-20
Inventor： Andreas Drechsler , Oliver Gutmann , Melis Hazar , Reto Huesser , Raymond T. Kozikowski, III , Daniel Mueller , Chris Steinert
CPC classification number: G01N35/1016 , G01N1/312 , G01N35/1002 , G01N35/1011 , G01N35/1009 , G01N2001/317 , G01N2035/1041
Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.
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公开(公告)号：US11668726B2
公开(公告)日：2023-06-06
申请号：US16388797
申请日：2019-04-18
Inventor： Andreas Drechsler , Oliver Gutmann , Melis Hazar , Reto Huesser , Raymond T. Kozikowski, III , Daniel Mueller , Chris Steinert
CPC classification number: G01N35/1016 , G01N1/312 , G01N35/1002 , G01N35/1009 , G01N35/1011 , G01N2001/317 , G01N2035/1041
Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.
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公开(公告)号：US10436685B2
公开(公告)日：2019-10-08
申请号：US15417858
申请日：2017-01-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Claudio Cherubini , Martin Kopp , Nenad Milicevic , Daniel Mueller , Emad Sarofim , Goran Savatic
IPC: G01N1/40 , G01N15/04 , G01N35/00 , G01N35/10 , B01L3/00 , B04B11/04 , B04B13/00 , B04B5/04 , B04B7/08 , C12M1/00
Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
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公开(公告)号：US20180010990A1
公开(公告)日：2018-01-11
申请号：US15417858
申请日：2017-01-27
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Claudio Cherubini , Martin Kopp , Nenad Milicevic , Daniel Mueller , Emad Sarofim , Goran Savatic
IPC: G01N1/40 , B04B5/04 , B04B7/08 , B01L3/00 , G01N35/10 , G01N35/00 , G01N15/04 , B04B13/00 , B04B11/04
CPC classification number: G01N1/4077 , B01L3/5021 , B01L2300/0848 , B01L2300/0858 , B01L2300/168 , B01L2400/086 , B04B5/0407 , B04B7/08 , B04B11/04 , B04B13/00 , C12M47/02 , G01N1/405 , G01N15/042 , G01N35/00584 , G01N35/10 , G01N2001/4083 , G01N2015/045 , Y10T436/111666 , Y10T436/25375
Abstract: A method for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion comprising a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion comprising a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion comprising a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
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公开(公告)号：US09606140B2
公开(公告)日：2017-03-28
申请号：US14286194
申请日：2014-05-23
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Geza Burghardt , Michael Glauser , Oliver Gutmann , Daniel Mueller , Edwin Oosterbroek , Roger Sandoz , Emad Sarofim , Goran Savatic
CPC classification number: G01P15/02 , B01L3/5021 , B01L3/5453 , B01L2200/14 , B01L2200/143 , B01L2300/021 , B01L2300/025 , B01L2300/0663 , B01L2400/0409
Abstract: An acceleration sensitive indicator for indicating a centrifugation status of a biological sample, a sample container comprising the indicator, a centrifuge for centrifuging samples and an analytical system for analyzing centrifuged samples are disclosed. The indicator comprises at least one closed chamber, formed between two opposite surfaces, that comprises an indication zone that comprises at least two fluid transfer zones or at least one particle transfer zone. The at least one fluid transfer zone comprises a solid carrier phase and a fluid stabilized in the solid carrier phase or at least one non-stabilized non-Newtonian fluid having thixotropic and/or shear thinning properties. The at least one particle transfer zone comprises a particle stabilizing fluid comprising stabilized dispersed particles. The fluid or particles have a distribution with respect to the indication zone changeable upon application of a g-force above a threshold value, the change of distribution indicating the centrifugation status.
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Patent Agency Ranking
公开(公告)号：US20250001424A1
公开(公告)日：2025-01-02
申请号：US18692099
申请日：2022-09-13
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Daniel Mueller
IPC: B01L9/06
Abstract: A centering holder for centering and holding one sample tube the centering holder being adaptable to sample tubes having different diameters is disclosed. The centering holder comprises: at least two coupled centering fingers arranged and configured to adapt to the diameter of the sample tube and for applying a centering force onto the sample tube in a direction towards a center axis of the centering holder, wherein each of the centering fingers comprises at least one rod element and at least one sleeve, wherein the sleeve at least partially surrounds the rod element, wherein the sleeve is configured for physically contacting the sample tube thereby transferring the centering force onto the sample tube; and at least one base element configured for supporting the at least two rod elements of the centering fingers.
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公开(公告)号：US20200033240A1
公开(公告)日：2020-01-30
申请号：US16542786
申请日：2019-08-16
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Claudio Cherubini , Martin Kopp , Nenad Milicevic , Daniel Mueller , Emad Sarofim , Goran Savatic
IPC: G01N1/40 , B01L3/00 , C12M1/00 , B04B5/04 , B04B7/08 , B04B11/04 , B04B13/00 , G01N15/04 , G01N35/00 , G01N35/10
Abstract: A method and system for processing particles contained in a liquid biological sample is presented. The method uses a rotatable vessel for processing particles contained in a liquid biological sample. The rotatable vessel has a longitudinal axis about which the vessel is rotatable, an upper portion having a top opening for receiving the liquid comprising the particles, a lower portion for holding the liquid while the rotatable vessel is resting, the lower portion having a bottom, and an intermediate portion located between the upper portion and the lower portion, the intermediate portion having a lateral collection chamber for holding the liquid while the rotatable vessel is rotating. The method employs dedicated acceleration and deceleration profiles for sedimentation and re-suspension of the particles of interest.
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公开(公告)号：US20190293670A1
公开(公告)日：2019-09-26
申请号：US16295179
申请日：2019-03-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Daniel Mueller
Abstract: A method for unsealing an opening of a laboratory sample container containing a sample is presented. The opening is sealed by a closure attached to the laboratory sample container by an adhesive. An adhesive strength of the adhesive is lowerable by treatment. The method comprises treating the adhesive such that its adhesive strength is lowered and removing the closure from the laboratory sample container.
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公开(公告)号：US20190242921A1
公开(公告)日：2019-08-08
申请号：US16388797
申请日：2019-04-18
Inventor： Andreas Drechsler , Oliver Gutmann , Melis Hazar , Reto Huesser , Raymond T. Kozikowski, III , Daniel Mueller , Chris Steinert
CPC classification number: G01N35/1016 , G01N1/312 , G01N35/1002 , G01N35/1009 , G01N35/1011 , G01N2001/317 , G01N2035/1041
Abstract: A system and method for treatment of biological samples is disclosed. In some embodiments, an automated biological sample staining system (100), comprising at least one microfluidic reagent applicator (118); at least one bulk fluid applicator (116); at least one fluid aspirator; at least one sample substrate holder; at least one relative motion system; and a control system (102) that is programmed to execute at least one staining protocol on a sample mounted on a substrate that is held in the at least one sample substrate holder.
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公开(公告)号：US20240198347A1
公开(公告)日：2024-06-20
申请号：US18532264
申请日：2023-12-07
Applicant: Roche Diagnostics Operations, Inc.
Inventor： Daniel Mueller , Claudio Cherubini , Dirk Abeln , Reto Huesser , Marko Simic , Nenad Milicevic , Michael Zeder
CPC classification number: B01L9/50 , B01L9/06 , G01N35/00584 , B01L2200/025 , B01L2200/0689 , B01L2300/041 , B01L2300/12
Abstract: The present invention relates to an instrument for automatically removing sealing covers from sample vessels (and/or for automatically sealing or resealing sample vessels with sealing covers, the instrument comprising a vessel holder for holding a sample vessel, and a suction/induction device comprising a suction member for holding a sealing cover, and an induction member comprising at least one induction coil, with the suction/induction device and the vessel holder being arranged in an axially movable manner with regard to each other, and, in use, the at least one induction coil is arranged above a bottom of the suction member. In addition, the present invention relates to a laboratory automation system comprising such instrument as well as a plurality of pre-analytical, analytical and/or post-analytical stations, and also relates to a method of automatically removing sealing covers from sample vessels and a method of automatically sealing or resealing sample vessels with sealing covers.
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