公开(公告)号：US12203124B2

公开(公告)日：2025-01-21

申请号：US16472714

申请日：2017-12-22

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric Stern ,  Aleksandar Vacic ,  Kelly Flentie ,  Benjamin Spears ,  Felicia Chen

IPC: C12Q1/18 ,  C07D257/04 ,  C07D403/10 ,  C07D417/04 ,  C07F5/00 ,  G01N21/64

Abstract: The present invention provides for improved antimicrobial susceptibility testing and more specifically for improved rapid antimicrobial susceptibility testing of clinical samples for efficient and versatile analysis and reliable results.

公开(公告)号：US12129510B2

公开(公告)日：2024-10-29

申请号：US18524578

申请日：2023-11-30

Applicant: SeLux Diagnostics, Inc.

Inventor： Kelly Flentie ,  Eric Stern

IPC: C12Q1/20 ,  C12Q3/00 ,  G16H10/40 ,  G16H20/10

CPC classification number: C12Q1/20 ,  C12Q3/00 ,  G16H10/40 ,  G16H20/10

Abstract: An improved system, method and interface for automated rapid antimicrobial susceptibility testing (AST) is disclosed which includes, in one aspect, a carrier population station comprising a workstation having a graphic user interface (GUI). The GUI accepts information from a lab technologist, including information related to a scope of testing to be performed on a patient sample. The GUI controls intelligent assignment of patient samples to test panels in a manner that maximize utilization of the test carrier by grouping together samples of similar tests scopes and advantageously testing those samples using one multiplexed test panel. Customizing workflow in accordance with test scope to facilitate parallel processing of multiple samples advantageously reduces laboratory waste, decreases test latencies, increases AST system throughput and efficiency, and thus lowers the costs to the AST lab.

公开(公告)号：US11828766B2

公开(公告)日：2023-11-28

申请号：US16226164

申请日：2018-12-19

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Aleksandar Vacic ,  Nathan Purmort ,  Eric Stern ,  Anna Passernig ,  Paul Otten ,  Randy Tragni ,  Ronan Hayes ,  Andriy Tsupryk ,  Bruce Richardson

IPC: G01N35/02 ,  G01N35/00 ,  G01N35/10 ,  B01J20/04 ,  C12Q1/18 ,  G01N21/01 ,  C12M1/00 ,  C12M1/26 ,  C12M1/36 ,  C12M1/34 ,  G01N35/04 ,  G01N15/02

CPC classification number: G01N15/02 ,  B01J20/041 ,  C12Q1/18 ,  G01N21/01 ,  G01N35/00 ,  G01N35/00029 ,  G01N35/0099 ,  G01N35/028 ,  G01N35/1065 ,  C12M33/10 ,  C12M41/36 ,  C12M41/48 ,  C12M47/02 ,  G01N2021/0112 ,  G01N2035/00039 ,  G01N2035/00118 ,  G01N2035/00148 ,  G01N2035/00237 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00465 ,  G01N2035/00485 ,  G01N2035/00524 ,  G01N2035/00841 ,  G01N2035/0425

Abstract: In some aspects, automated rapid antimicrobial susceptibility testing systems for performing a multi-assay testing sequence can include an automated incubation assembly having a nest assembly adapted to house at least one test panel having a plurality of wells for receiving a sample comprising microorganisms originating from a clinical sample, the incubation assembly facilitating incubation of one or more test panels in order to undergo the multi-assay testing sequence; a robotic handling assembly configured to accept one or more incoming test panels and move them to and from the incubation assembly for incubation between each assay of the multi-assay testing sequence; an automated liquid handling assembly configured to exchange one or more fluids in the plurality of wells of the test panels; and an optical assembly for interrogation and readout of each assay of the multi-assay testing sequence being performed in the plurality of wells.

公开(公告)号：US20210317504A1

公开(公告)日：2021-10-14

申请号：US17233133

申请日：2021-04-16

Applicant: SeLux Diagnostics, Inc.

Inventor： Eric Stern ,  Aleksandar Vacic ,  Benjamin Spears ,  Alec Flyer ,  Kelly Flentie

IPC: C12Q1/18 ,  C12Q1/02

Abstract: The present invention relates, in part, to methods and kits for rapidly determining antimicrobial susceptibility of microorganisms.

公开(公告)号：US20210010053A1

公开(公告)日：2021-01-14

申请号：US16925719

申请日：2020-07-10

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric Stern ,  Kelly Flentie ,  Nicholas Phelan, JR. ,  Mark Somers

IPC: C12Q1/18 ,  C12Q1/34

Abstract: Phenotypic antimicrobial susceptibility testing (AST), the gold-standard diagnostic that indicates whether an antimicrobial will be clinically effective, often suffer the slowest times-to-result for the most resistant pathogens. Here we introduce novel assays to be performed in parallel with standard AST assays that enable rapid, same-shift reporting of AST results for a plurality of pathogens. The assays developed here are further capable of detecting resistance to carbapenems, the most powerful class of beta-lactams commonly used as “last-resort” antimicrobials.

公开(公告)号：US20200157597A1

公开(公告)日：2020-05-21

申请号：US16684056

申请日：2019-11-14

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Kelly Flentie ,  Eric Stern

IPC: C12Q1/20 ,  C12Q3/00 ,  G16H10/40 ,  G16H20/10

Abstract: An improved system, method and interface for automated rapid antimicrobial susceptibility testing (AST) is disclosed which includes, in one aspect, a carrier population station comprising a workstation having a graphic user interface (GUI). The GUI accepts information from a lab technologist, including information related to a scope of testing to be performed on a patient sample. The GUI controls intelligent assignment of patient samples to test panels in a manner that maximize utilization of the test carrier by grouping together samples of similar tests scopes and advantageously testing those samples using one multiplexed test panel. Customizing workflow in accordance with test scope to facilitate parallel processing of multiple samples advantageously reduces laboratory waste, decreases test latencies, increases AST system throughput and efficiency, and thus lowers the costs to the AST lab.

公开(公告)号：US20190301987A1

公开(公告)日：2019-10-03

申请号：US16290663

申请日：2019-03-01

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Benjamin Spears ,  Kelly Flentie ,  Aleksandar Vacic ,  Eric Stern

IPC: G01N1/40

Abstract: The present disclosure provides novel methods for microbiological sample preparation from patients that yield high quality input material for antimicrobial susceptibility testing (AST) without the need for plate culture. Certain methods of this disclosure comprise multiple separation steps to purify microbial samples for use in ASTs.

公开(公告)号：US11866763B2

公开(公告)日：2024-01-09

申请号：US16684056

申请日：2019-11-14

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Kelly Flentie ,  Eric Stern

IPC: C12Q1/20 ,  G16H20/10 ,  G16H10/40 ,  C12Q3/00

CPC classification number: C12Q1/20 ,  C12Q3/00 ,  G16H10/40 ,  G16H20/10

Abstract: An improved system, method and interface for automated rapid antimicrobial susceptibility testing (AST) is disclosed which includes, in one aspect, a carrier population station comprising a workstation having a graphic user interface (GUI). The GUI accepts information from a lab technologist, including information related to a scope of testing to be performed on a patient sample. The GUI controls intelligent assignment of patient samples to test panels in a manner that maximize utilization of the test carrier by grouping together samples of similar tests scopes and advantageously testing those samples using one multiplexed test panel. Customizing workflow in accordance with test scope to facilitate parallel processing of multiple samples advantageously reduces laboratory waste, decreases test latencies, increases AST system throughput and efficiency, and thus lowers the costs to the AST lab.

公开(公告)号：US20220170934A1

公开(公告)日：2022-06-02

申请号：US17672443

申请日：2022-02-15

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric Stern ,  Kelly Flentie ,  Nicholas Phelan

IPC: G01N33/573 ,  G01N33/58 ,  G01N33/50 ,  C12Q1/04 ,  C12Q1/34

Abstract: Phenotypic antimicrobial susceptibility testing (AST), the gold-standard diagnostic that indicates whether an antimicrobial will be clinically effective, often suffer the slowest times-to-result for the most resistant pathogens. Here we introduce novel assays to be performed in parallel with standard AST assays that enable rapid, same-shift reporting of AST results for a plurality of pathogens. The assays developed here are further capable of detecting resistance to carbapenems, the most powerful class of beta-lactams commonly used as “last-resort” antimicrobials.

公开(公告)号：US11268960B2

公开(公告)日：2022-03-08

申请号：US16245092

申请日：2019-01-10

Applicant: SELUX DIAGNOSTICS, INC.

Inventor： Eric Stern ,  Kelly Flentie ,  Nicholas Phelan

IPC: G01N33/573 ,  G01N33/50 ,  G01N33/58 ,  C12Q1/04 ,  C12Q1/34

Abstract: Phenotypic antimicrobial susceptibility testing (AST), the gold-standard diagnostic that indicates whether an antimicrobial will be clinically effective, often suffer the slowest times-to-result for the most resistant pathogens. Here we introduce novel assays to be performed in parallel with standard AST assays that enable rapid, same-shift reporting of AST results for a plurality of pathogens. The assays developed here are further capable of detecting resistance to carbapenems, the most powerful class of beta-lactams commonly used as “last-resort” antimicrobials.