公开(公告)号：US11011364B2

公开(公告)日：2021-05-18

申请号：US16913553

申请日：2020-06-26

Applicant: SHIMADZU CORPORATION

Inventor： Aleksandr Rusinov ,  Li Ding

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/40 ,  H01J49/02

Abstract: An apparatus configured to produce an image charge/current signal representative of trapped ions undergoing oscillatory motion. The apparatus includes: an electrostatic ion trap configured to trap ions such that the trapped ions undergo oscillatory motion in the electrostatic ion trap; an image charge/current detector configured to obtain an image charge/current signal representative of trapped ions undergoing oscillatory motion in the electrostatic ion trap, wherein the electrostatic ion trap configured to trap ions such that the image charge/current signal in the time domain repeats, for ions of a given mass/charge ratio m, at a frequency fsig(m) [Hz] with a signal period Tsig(m) [s]. The image charge/current detector includes one or more pickup electrodes configured to obtain the image charge/current signal. The one or more pickup electrodes are arranged to detect two signal pulses caused by ions having the given mass/charge ratio m within each signal period Tsig(m). The one or more pickup electrodes are further arranged such that the time separation Δtsep(m) between the two signal pulses caused by ions having the given mass/charge ratio m within each signal period Tsig(m) is approximately equal to 2p+1/2.n.fsig(m) so as to suppress a predetermined nth harmonic within the image charge/current signal, where n is an integer that is 1 or more, and where p is an integer that is 0 or more.

公开(公告)号：US08890060B2

公开(公告)日：2014-11-18

申请号：US14201187

申请日：2014-03-07

Applicant: Shimadzu Corporation

Inventor： Li Ding ,  Ranjan Badheka

IPC: H01J49/04 ,  H01J49/40 ,  G06K9/00 ,  H01J49/00 ,  G06T5/00 ,  H01J49/10

CPC classification number: H01J49/0004 ,  G06T5/00 ,  H01J49/0036 ,  H01J49/027 ,  H01J49/10

Abstract: A method of processing an image charge/current signal representative of trapped ions undergoing oscillatory motion. The method includes applying a validity test to each of a plurality of peaks in the image charge/current signal in the frequency domain, wherein applying the validity test to a peak in the image charge/current signal in the frequency domain includes determining whether a phase angle associated with the peak meets a predetermined condition. The method also includes forming a new image charge/current signal that: includes data representative of one or more peaks that have passed the validity test; and excludes data representative of one or more peaks that have failed the validity test. The method may be performed by a mass spectrometry apparatus.

Abstract translation: 一种处理代表被捕获的离子进行振荡运动的图像充电/电流信号的方法。 该方法包括对频域中的图像充电/电流信号中的多个峰值中的每一个应用有效性测试，其中将频率域中的图像充电/电流信号中的峰值应用于有效性测试包括： 与峰值相关联的角度满足预定条件。 该方法还包括形成新的图像充电/电流信号：包括表示通过有效性测试的一个或多个峰值的数据; 并排除代表有效性测试失败的一个或多个峰的数据。 该方法可以通过质谱装置进行。

公开(公告)号：US09691596B2

公开(公告)日：2017-06-27

申请号：US14877593

申请日：2015-10-07

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/02 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06 ,  H01J49/40

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

公开(公告)号：US08664590B2

公开(公告)日：2014-03-04

申请号：US13838357

申请日：2013-03-15

Applicant: Shimadzu Corporation

Inventor： Li Ding ,  Ranjan Badheka

IPC: H01J49/26 ,  B01D59/44

CPC classification number: H01J49/0004 ,  G06T5/00 ,  H01J49/0036 ,  H01J49/027

Abstract: A method of processing a plurality of image charge/current signals representative of trapped ions undergoing oscillatory motion, e.g. for use in an ion trap mass spectrometer. The method includes producing a linear combination of the plurality of image charge/current signals using a plurality of predetermined coefficients, the predetermined coefficients having been selected so as to suppress at least one harmonic component of the image charge/current signals within the linear combination of the plurality of image charge/current signals.

Abstract translation: 一种处理表示经历振荡运动的被俘获的离子的多个图像充电/电流信号的方法，例如， 用于离子阱质谱仪。 该方法包括使用多个预定系数产生多个图像充电/电流信号的线性组合，所选择的预定系数以便抑制在线性组合内的图像充电/电流信号的至少一个谐波分量 多个图像充电/电流信号。

公开(公告)号：US10381208B2

公开(公告)日：2019-08-13

申请号：US16072550

申请日：2017-03-22

Applicant: SHIMADZU CORPORATION

Inventor： Sergey Smirnov ,  Li Ding ,  Aleksandr Rusinov

IPC: H01J49/00 ,  H01J49/42 ,  H01J49/02

Abstract: A method of processing an image charge/current signal representative of trapped ions undergoing oscillatory motion. The method includes: identifying a plurality of fundamental frequencies potentially present in the image charge/current signal based on an analysis of peaks in a frequency spectrum corresponding to the image charge/current signal in the frequency domain, wherein each candidate fundamental frequency falls in a frequency range of interest; deriving a basis signal for each candidate fundamental frequency using a calibration signal; and estimating relative abundances of ions corresponding to the candidate fundamental frequencies by mapping the basis signals to the image charge/current signal. At least one candidate fundamental frequency is calculated using a frequency associated with a peak that falls outside the frequency range of interest and that has been determined as representing a second or higher order harmonic of the candidate fundamental frequency.

公开(公告)号：US10242854B2

公开(公告)日：2019-03-26

申请号：US15524373

申请日：2015-10-30

Applicant: SHIMADZU CORPORATION

Inventor： Aleksandr Rusinov ,  Li Ding

IPC: H01J49/00 ,  H01J49/38 ,  H01J49/42

Abstract: Disclosed is a method of quantification of one or more ion species, in a sample of ions, using a mass spectrometer, the method including the steps of: obtaining a time domain data set corresponding to a signal induced by motion of the ions in the mass spectrometer; adjusting the data set by applying an asymmetric window function thereto; generating an absorption mode mass spectrum in the frequency domain including the step of applying a Fourier transform to the adjusted data set; determining peak ranges for one or more peaks in the mass spectrum associated with the one or more ion species; integrating, for each determined peak range, the spectral data within the respective peak range to generate a respective peak intensity value; and quantifying each of the one or more ion species on the basis of the respective peak intensity values.

公开(公告)号：US09997343B2

公开(公告)日：2018-06-12

申请号：US15618959

申请日：2017-06-09

Applicant: SHIMADZU CORPORATION

Inventor： Li Ding ,  Mikhail Sudakov ,  Sumio Kumashiro

IPC: H01J49/40 ,  H01J49/02 ,  H01J49/42 ,  H01J49/00 ,  H01J49/06

CPC classification number: H01J49/027 ,  H01J49/0031 ,  H01J49/061 ,  H01J49/406 ,  H01J49/408 ,  H01J49/4245

Abstract: An electrostatic ion trap for mass analysis includes a first array of electrodes and a second array of electrodes, spaced from the first array of electrode. The first and second arrays of electrodes may be planar arrays formed by parallel strip electrodes or by concentric, circular or part-circular electrically conductive rings. The electrodes of the arrays are supplied with substantially the same pattern of voltage whereby the distribution of electrical potential in the space between the arrays is such as to reflect ions isochronously in a flight direction causing them to undergo periodic, oscillatory motion in the space, focused substantially mid-way between the arrays. Amplifier circuitry is used to detect image current having frequency components related to the mass-to-charge ratio of ions undergoing the periodic, oscillatory motion.

公开(公告)号：US09628051B2

公开(公告)日：2017-04-18

申请号：US15168762

申请日：2016-05-31

Applicant: SHIMADZU CORPORATION

Inventor： Steven Douglas Taylor ,  Matthew Clive Gill ,  Li Ding ,  James Edward Nuttall

IPC: H03K17/00 ,  H03K3/012 ,  H03K5/00 ,  H03K17/687 ,  H02M7/537 ,  H03K3/356 ,  H01J49/02 ,  H02M7/48

CPC classification number: H03K3/012 ,  H01J49/022 ,  H02M7/537 ,  H02M2007/4815 ,  H03K3/356 ,  H03K5/00006 ,  H03K17/6871 ,  H03K17/6874 ,  Y02B70/1441

Abstract: A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance. The circuit may be included in an apparatus for use in processing charged particles, e.g. for use in performing mass spectrometry or ion mobility spectrometry.

公开(公告)号：US09461629B2

公开(公告)日：2016-10-04

申请号：US14754127

申请日：2015-06-29

Applicant: SHIMADZU CORPORATION

Inventor： Steven Douglas Taylor ,  Matthew Clive Gill ,  Li Ding ,  James Edward Nuttall

IPC: H03K17/00 ,  H03K3/012 ,  H03K5/00 ,  H03K17/687 ,  H02M7/537 ,  H03K3/356 ,  H01J49/02 ,  H02M7/48

CPC classification number: H03K3/012 ,  H01J49/022 ,  H02M7/537 ,  H02M2007/4815 ,  H03K3/356 ,  H03K5/00006 ,  H03K17/6871 ,  H03K17/6874 ,  Y02B70/1441

Abstract: A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor and the load capacitance. The circuit may be included in an apparatus for use in processing charged particles, e.g. for use in performing mass spectrometry or ion mobility spectrometry.

Abstract translation: 用于在输出节点处产生电压波形的电路。 电路包括经由电压轨开关连接到输出节点的电压轨; 经由电感器和双向开关连接到输出节点的锚节点，其中所述双向开关包括串联连接的两个或更多个晶体管; 以及控制单元，被配置为通过控制电压轨开关和双向开关来改变输出节点处的电压，使得如果负载电容连接到输出节点，则在电感器和负载电容之间建立谐振电路。 电路可以包括在用于处理带电粒子的装置中，例如， 用于进行质谱或离子迁移谱。

公开(公告)号：US09391593B2

公开(公告)日：2016-07-12

申请号：US14268474

申请日：2014-05-02

Applicant: SHIMADZU CORPORATION

Inventor： Steven Douglas Taylor ,  Matthew Clive Gill ,  Li Ding ,  James Edward Nuttall

IPC: H03K17/00 ,  H03K3/012 ,  H03K5/00 ,  H03K17/687 ,  H02M7/537 ,  H03K3/356 ,  H01J49/02 ,  H02M7/48

CPC classification number: H03K3/012 ,  H01J49/022 ,  H02M7/537 ,  H02M2007/4815 ,  H03K3/356 ,  H03K5/00006 ,  H03K17/6871 ,  H03K17/6874 ,  Y02B70/1441

Abstract: A circuit for generating a voltage waveform at an output node. The circuit includes a voltage rail connected to the output node via a voltage rail switch; an anchor node 5 connected to the output node via an inductor and a bidirectional switch, wherein the bidirectional switch includes two or more transistors connected in series; and a control unit configured to change the voltage at the output node by controlling the voltage rail switch and the bidirectional switch so that, if a load capacitance is connected to the output node, a resonant circuit is established between the inductor 10 and the load capacitance. The circuit may be included in an apparatus for use in processing charged particles, e.g. for use in performing mass spectrometry or ion mobility spectrometry.

Abstract translation: 用于在输出节点处产生电压波形的电路。 电路包括经由电压轨开关连接到输出节点的电压轨; 经由电感器和双向开关连接到输出节点的锚节点5，其中所述双向开关包括串联连接的两个或更多个晶体管; 以及控制单元，被配置为通过控制电压轨开关和双向开关来改变输出节点处的电压，使得如果负载电容连接到输出节点，则在电感器10和负载电容之间建立谐振电路 。 电路可以包括在用于处理带电粒子的装置中，例如， 用于进行质谱或离子迁移谱。