公开(公告)号：US09650414B1

公开(公告)日：2017-05-16

申请号：US14726020

申请日：2015-05-29

Applicant: Simon Fraser University

Inventor： Robert N. Young ,  Gang Chen ,  Haibo Xie

IPC: C07K5/06 ,  C07K5/062 ,  A61K38/00

CPC classification number: C07K5/06043 ,  A61K38/00 ,  A61K47/548

Abstract: The invention provides in part, compounds according to Formula I: and uses thereof.

公开(公告)号：US10400000B2

公开(公告)日：2019-09-03

申请号：US15735372

申请日：2016-06-13

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion Thévenin ,  Robert N. Young ,  Gang Chen

IPC: A61K47/30 ,  A61P19/08 ,  C07F9/572 ,  C07F9/38 ,  A61K47/54

Abstract: The present invention relates to conjugate compounds and methods of making and using same.

公开(公告)号：US11312737B2

公开(公告)日：2022-04-26

申请号：US16518132

申请日：2019-07-22

Applicant: SIMON FRASER UNIVERSITY

Inventor： Marion Thévenin ,  Robert N. Young ,  Gang Chen

IPC: C07F9/572 ,  C07F9/38 ,  A61K47/54 ,  A61P19/08

Abstract: The present invention relates to EP4 agonist-bisphosphonate conjugates or related compounds and uses thereof. Said conjugates or related compounds may be used to provide delivery of an EP4 agonist or related compound to a desired site of action, such as a bone. Bisphosphonate moieties, linked to the EP4 agonists via amide linkers, have been implicated in the inhibition of bone resorption and bone targeting.