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公开(公告)号：US09023142B2
公开(公告)日：2015-05-05
申请号：US14346893
申请日：2012-10-29
Applicant: Spiber Inc.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
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公开(公告)号：US08979992B2
公开(公告)日：2015-03-17
申请号：US14346893
申请日：2012-10-29
Applicant: Spiber Inc.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
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公开(公告)号：US11348154B2
公开(公告)日：2022-05-31
申请号：US16513767
申请日：2019-07-17
Applicant: SPIBER INC.
Inventor： Kazuhide Sekiyama , Goshi Uhira
Abstract: An information processing method performed by a processor, the method comprises garment selecting of receiving a selection of a garment from a user, price calculating of calculating a price of the garment on the basis of a type of the selected garment and parameters relating to a design and materials set for the garment, display controlling of causing a display part to display the calculated price, and parameter changing of changing the parameters in conjunction with an input from the user. The display controlling includes causing the display part to display the price that reflects the changed parameters in response to the change of the parameters.
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4.发明授权Polypeptide solution, artificial polypeptide fiber production method and polypeptide purification method using same 有权多肽溶液，人造多肽纤维生产方法和多肽纯化方法使用相同公开(公告)号：US09051453B2
公开(公告)日：2015-06-09
申请号：US14346893
申请日：2012-10-29
Applicant: SPIBER INC.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
CPC classification number: C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
Abstract translation: 本发明的多肽溶液是多肽溶液，其中衍生自天然蜘蛛丝蛋白的多肽溶解在溶剂中。 溶剂含有选自以下（i） - （iii）中的至少一种：（i）DMSO; （ii）具有无机盐的DMSO; 和（iii）具有无机盐的DMF。 此外，在本发明中，通过以下方式获得人造多肽纤维：使用多肽溶液作为掺杂溶液; 将喷丝头溶液从喷丝头挤出到去溶剂浴中，以从溶剂溶液中除去溶剂，并形成纤维以产生未拉伸的纱线。 此外，在本发明中，通过使多肽溶液进行热处理，然后从其中除去未溶解的物质来纯化多肽。 因此，本发明提供了溶质具有高溶解度且溶剂本身具有低成本且能够在高温下溶解并具有高安全性的多肽溶液。人造多肽纤维的制造方法以及纯化多肽的方法。
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5.发明申请公开(公告)号：US20140245923A1
公开(公告)日：2014-09-04
申请号：US14346893
申请日：2012-10-29
Applicant: SPIBER INC.
Inventor： Junichi Sugahara , Kazuhide Sekiyama , Ryota Sato , Kaori Sekiyama , Mizuki Ishikawa , Shinya Murata , Kazuko Otomo
IPC: C08K5/41 , B29D99/00 , C08K3/16 , C07K14/435 , C08K5/16
CPC classification number: C08K5/41 , B29D99/0078 , C07K14/43518 , C08K3/16 , C08K5/20 , D01D5/04 , D01F4/02 , D01F6/68 , Y10S530/858
Abstract: A polypeptide solution of the present invention is a polypeptide solution in which a polypeptide derived from natural spider silk proteins is dissolved in a solvent. The solvent contains at least one selected from the following (i)-(iii): (i) DMSO; (ii) DMSO with an inorganic salt; and (iii) DMF with an inorganic salt. Further, in the present invention, an artificial polypeptide fiber is obtained by: using the polypeptide solution as a dope solution; and extruding the dope solution from a spinneret into a desolvation bath so as to eliminate the solvent from the dope solution and form a fiber to produce an undrawn yarn. Moreover, in the present invention, a polypeptide is purified by subjecting the polypeptide solution to heat treatment and thereafter removing an undissolved substance therefrom. Thus, the present invention provides the polypeptide solution whose solute has high solubility and solvent itself is low cost, and that allows dissolution at high temperatures and has high safety: a method for producing an artificial polypeptide fiber: and a method for purifying a polypeptide.
Abstract translation: 本发明的多肽溶液是多肽溶液，其中衍生自天然蜘蛛丝蛋白的多肽溶解在溶剂中。 溶剂含有选自以下（i） - （iii）中的至少一种：（i）DMSO; （ii）具有无机盐的DMSO; 和（iii）具有无机盐的DMF。 此外，在本发明中，通过以下方式获得人造多肽纤维：使用多肽溶液作为掺杂溶液; 将喷丝头溶液从喷丝头挤出到去溶剂浴中，以从溶剂溶液中除去溶剂，并形成纤维以产生未拉伸的纱线。 此外，在本发明中，通过使多肽溶液进行热处理，然后从其中除去未溶解的物质来纯化多肽。 因此，本发明提供了溶质具有高溶解度且溶剂本身具有低成本且能够在高温下溶解并具有高安全性的多肽溶液。人造多肽纤维的制造方法以及纯化多肽的方法。
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Patent Agency Ranking
公开(公告)号：US20190352330A1
公开(公告)日：2019-11-21
申请号：US16473836
申请日：2017-12-25
Applicant: Spiber Inc.
Inventor： Kazuhide Sekiyama , Akihiko Ozeki , Ryoji Okada , Koichi Kotaka
IPC: C07K1/14 , C07K14/435 , C08J11/08 , C08J11/20
Abstract: The present invention relates to a method for recovering protein, which recovers a target protein from a mixture containing the target protein and a material different from the target protein, the method including a dissolution step of dissolving either the target protein or the material by applying pressure while heating to a solution for dissolution containing the mixture and a polar solvent, and a separation step of separating an obtained solution.
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公开(公告)号：US10975206B2
公开(公告)日：2021-04-13
申请号：US15564373
申请日：2016-04-04
Applicant: SPIBER INC.
Inventor： Kana Ishida , Hironori Yamamoto , Hiroaki Suzumura , Kazuhide Sekiyama
Abstract: A polar solvent solution of the present invention is a polar solvent solution in which a solute containing a polyamine acid is dissolved in a polar solvent. An inorganic salt is added to the solution, and a mole ratio of moisture to the inorganic salt in the solution is 2.5×m×n or less, where m represents the number of cations forming the inorganic salt and n represents a charge number of the cation. A production method of the present invention is a method for producing the above solution, including: changing at, least one of a moisture content and a content of the inorganic salt in the solution to adjust a viscosity of the solution. Thus, the present invention provides a polar solvent solution whose viscosity can be easily adjusted to a desired value and thus enables stable spinning and casting when used as dopes for spinning, film, etc., and methods for producing the same.
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公开(公告)号：US20190340666A1
公开(公告)日：2019-11-07
申请号：US16513767
申请日：2019-07-17
Applicant: SPIBER INC.
Inventor： Kazuhide Sekiyama , Goshi Uhira
Abstract: An information processing method performed by a processor, the method comprises garment selecting of receiving a selection of a garment from a user, price calculating of calculating a price of the garment on the basis of a type of the selected garment and parameters relating to a design and materials set for the garment, display controlling of causing a display part to display the calculated price, and parameter changing of changing the parameters in conjunction with an input from the user. The display controlling includes causing the display part to display the price that reflects the changed parameters in response to the change of the parameters.
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公开(公告)号：US20150141618A1
公开(公告)日：2015-05-21
申请号：US14405101
申请日：2013-04-26
Applicant: SPIBER INC.
Inventor： Mizuki Ishikawa , Kazuhide Sekiyama
IPC: D01F4/02 , D01D1/02 , D01D5/06 , C07K14/435 , D01D5/04
CPC classification number: D01F4/02 , C07K14/43518 , D01D1/02 , D01D5/04 , D01D5/06 , D01F1/06 , D01F4/00
Abstract: A solution-dyed protein fiber of the present invention includes 0-100 mass % of silk fibroin and 100-0 mass % of a polypeptide derived from spider silk proteins when the protein fiber is assumed to be 100 mass %, wherein the solution-dyed protein fiber contains a solution-dyeing colorant. The fiber is obtained by: dissolving or dispersing a solution-dyeing colorant in a solvent used for a spinning solution or in dimethyl sulfoxide, thereby preparing a coloring liquid; adding a solvent to the coloring liquid in an amount necessary for a spinning solution; adding and dissolving protein powder into the solvent, thereby preparing a spinning solution; and subjecting the spinning solution to wet spinning or dry-wet spinning. Thereby, the present invention provides a low-cost solution-dyed protein fiber in which a solution-dyeing colorant is dispersed uniformly and that can exhibit bright color tone, and a method for producing the same.
Abstract translation: 当蛋白质纤维假定为100质量％时，本发明的溶液染色蛋白质纤维包含0-100质量％的丝素蛋白和100-0质量％的衍生自蜘蛛丝蛋白的多肽，其中溶液染色 蛋白质纤维含有溶液染色剂。 纤维通过以下方法获得：将溶染染色剂溶解或分散在用于纺丝溶液或二甲基亚砜的溶剂中，从而制备着色液体; 以纺丝溶液所需的量向着色液中加入溶剂; 将蛋白粉加入溶解溶剂中，制备纺丝溶液; 并对纺丝溶液进行湿纺或干湿纺丝。 因此，本发明提供了一种低成本的溶染染色蛋白质纤维，其中染色着色剂均匀分散并且可以表现出明亮的色调，及其制备方法。
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公开(公告)号：US11668024B2
公开(公告)日：2023-06-06
申请号：US16740106
申请日：2020-01-10
Applicant: SPIBER INC.
Inventor： Kana Ishida , Hironori Yamamoto , Hiroaki Suzumura , Kazuhide Sekiyama
IPC: D01F4/02 , D01C3/00 , C07K14/435 , D01F1/02
CPC classification number: D01F4/02 , C07K14/435 , C07K14/43518 , D01C3/00 , D01F1/02
Abstract: A polar solvent solution of the present invention is a polar solvent solution in which a solute containing a polyamine acid is dissolved in a polar solvent. The solution has a moisture content of less than 5 mass % based on 100 mass % of the solution. A method for producing a polar solvent solution of the present invention includes changing a moisture content of the solution to adjust the viscosity of the solution. Further, another method for producing a polar solvent solution includes reducing a moisture content of the solution to increase the viscosity of the solution. Thus, the present invention provides a polar solvent solution that enables stable spinning and casting without lowering its viscosity when used as dopes for spinning, film, etc., and methods for producing the same.
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