公开(公告)号：US20240416123A1

公开(公告)日：2024-12-19

申请号：US18820458

申请日：2024-08-30

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：US20240366938A1

公开(公告)日：2024-11-07

申请号：US18772597

申请日：2024-07-15

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs ,  Maria E. Bennett ,  Amorn Wongsarnpigoon ,  John Chae ,  Warren M. Grill ,  Kathryn Stager ,  Rosemary Zang

IPC: A61N1/36 ,  A61B17/34 ,  A61N1/05

Abstract: It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

公开(公告)号：US20240065931A1

公开(公告)日：2024-02-29

申请号：US18502131

申请日：2023-11-06

Applicant: SPR Therapeutics, Inc.

Inventor： Meredith McGee ,  Nathan Crosby ,  John Chae ,  Joseph W. Boggs

IPC: A61H23/00

CPC classification number: A61H23/006 ,  A61H23/004 ,  A61H39/08 ,  A61H2203/03

Abstract: A system and method of using a lead introduced to a subject proximate to a region of pain is contemplated to deliver pain relief without the need for multiple needle insertions or electrical stimulation. The three-dimensional lead may include spring-like characteristics and/or coils to translate mechanical energy into the therapy.

公开(公告)号：US11806533B2

公开(公告)日：2023-11-07

申请号：US16842863

申请日：2020-04-08

Applicant: SPR Therapeutics, INC.

Inventor： Meredith McGee ,  Joseph W. Boggs ,  John Chae ,  Amorn Wongsarnpigoon ,  Maria E. Bennett

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36021

Abstract: The present invention reduces pain and improves function long-term in persons with back pain using electrical stimulation in the back. This approach involves an electrical stimulation device including at least one electrode adapted for insertion within an animal body with back pain and at least one pulse generator operatively coupled with the at least one electrode, wherein the pulse generator delivers electrical stimulation activating at least a nerve innervating at least a paraspinal muscle in a back of the animal body for pain relief.

公开(公告)号：US11806300B2

公开(公告)日：2023-11-07

申请号：US18084629

申请日：2022-12-20

Applicant: SPR Therapeutics, Inc.

Inventor： Meredith McGee ,  Nathan Crosby ,  John Chae ,  Joseph W. Boggs

IPC: A61H23/00 ,  A61H39/08

CPC classification number: A61H23/006 ,  A61H23/004 ,  A61H39/08 ,  A61H2203/03

Abstract: A system and method of using a lead introduced to a subject proximate to a region of pain is contemplated to deliver pain relief without the need for multiple needle insertions or electrical stimulation. The three-dimensional lead may include spring-like characteristics and/or coils to translate mechanical energy into the therapy.

公开(公告)号：US20230135669A1

公开(公告)日：2023-05-04

申请号：US18084629

申请日：2022-12-20

Applicant: SPR Therapeutics, Inc.

Inventor： Meredith McGee ,  Nathan Crosby ,  John Chae ,  Joseph W. Boggs

IPC: A61H23/00

Abstract: A system and method of using a lead introduced to a subject proximate to a region of pain is contemplated to deliver pain relief without the need for multiple needle insertions or electrical stimulation. The three-dimensional lead may include spring-like characteristics and/or coils to translate mechanical energy into the therapy.

公开(公告)号：US20190247652A1

公开(公告)日：2019-08-15

申请号：US16391362

申请日：2019-04-23

Applicant: SPR Therapeutics, Inc.

Inventor： Joseph W. Boggs, II ,  Maria E. Bennett ,  Amorn Wongsarnpigoon ,  John Chae ,  Warren M. Grill ,  Kathryn Stager ,  Rosemary Zang

IPC: A61N1/36 ,  A61N1/05 ,  A61B17/34

CPC classification number: A61N1/36021 ,  A61B17/3468 ,  A61N1/0502 ,  A61N1/0558 ,  A61N1/36017 ,  A61N1/36071

Abstract: It has been discovered that pain felt in a given region of the body can be treated by stimulating a peripheral nerve at a therapeutically effective distance from the region where pain is felt to generate a comfortable sensation (i.e., paresthesia) overlapping the regions of pain. A method has been developed to reduce pain in a painful region following limb joint replacement by stimulating a peripheral nerve innervating the painful region with an electrode inserted into tissue and spaced from the peripheral nerve. This method may be used to help alleviate postoperative pain in patients following total knee arthroplasty surgery or other limb joint replacement surgeries.

公开(公告)号：US20180133479A1

公开(公告)日：2018-05-17

申请号：US15854206

申请日：2017-12-26

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：US12214198B2

公开(公告)日：2025-02-04

申请号：US16132530

申请日：2018-09-17

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs, II ,  Warren M. Gill ,  John Chae

IPC: A61N1/36 ,  A61N1/05

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.

公开(公告)号：US12194299B2

公开(公告)日：2025-01-14

申请号：US17824981

申请日：2022-05-26

Applicant: SPR Therapeutics, Inc.

Inventor： Maria E. Bennett ,  Joseph W. Boggs ,  Warren M. Grill ,  John Chae

IPC: A61N1/36

Abstract: Embodiments of the present invention provide systems and methods for the treatment of pain through activation of select neural fibers. The neural fibers may comprise one or more afferent neural fibers and/or one or more efferent neural fibers. If afferent fibers are stimulated, alone or in combination with efferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate afferent pathways in a manner approximating natural afferent activity. The afferent fibers may be associated with primary receptors of muscle spindles, golgi tendon organs, secondary, receptors of muscle spindles, joint receptors, touch receptors, and other types of mechanoreceptors and/or proprioceptors. If efferent fibers are stimulated, alone or in combination with afferent fibers, a therapeutically effective amount of electrical stimulation is applied to activate intrafusal and/or extrafusal muscle fibers, which results in an indirect activation of afferent fibers associated therewith.