公开(公告)号：US20240257921A1

公开(公告)日：2024-08-01

申请号：US18635717

申请日：2024-04-15

Applicant: SRI International

Inventor： Peter B. Madrid ,  Nathan Collins ,  Mario Latendresse ,  Jeremiah Malerich ,  Markus Krummenacker

IPC: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

CPC classification number: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

公开(公告)号：US11639326B2

公开(公告)日：2023-05-02

申请号：US16500687

申请日：2018-04-06

Applicant: SRI INTERNATIONAL

Inventor： Nathan Collins ,  Jeremiah Malerich ,  Judy Szeto ,  Joseph A. Kozocas

IPC: C07C51/08 ,  C07C253/16 ,  C07C253/14 ,  C07C17/16 ,  C07C29/143 ,  C07C303/28 ,  C07C45/46 ,  C07C57/30 ,  C07C255/01

Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US11961595B2

公开(公告)日：2024-04-16

申请号：US16965222

申请日：2019-01-30

Applicant: SRI INTERNATIONAL

Inventor： Peter Madrid ,  Nathan Collins ,  Mario Latendresse ,  Jeremiah Malerich ,  Markus Krummenacker

IPC: G01N31/00 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70 ,  G16C20/80

CPC classification number: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

公开(公告)号：US20210114962A1

公开(公告)日：2021-04-22

申请号：US16500687

申请日：2018-04-06

Applicant: SRI INTERNATIONAL

Inventor： Nathan Collins ,  Jeremiah Malerich ,  Judy Szeto ,  Joseph A. Kozocas

IPC: C07C51/08 ,  C07C253/16

Abstract: This disclosure generally relates to methods of making ibuprofen, naproxen, and derivatives thereof. This disclosure also generally relates to compounds made by the disclosed methods. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240228495A1

公开(公告)日：2024-07-11

申请号：US17913824

申请日：2021-03-24

Applicant: SRI INTERNATIONAL

Inventor： Thomas R. Webb ,  Chandraiah Lagisetti ,  Diane Beylkin ,  Jaehyeon Park ,  Wei Zhou ,  Peter Madrid ,  Leyi Gong ,  Jeremiah Malerich ,  Chat Gheong Gabriel Fung ,  Raymond Ng ,  Quentin Perron ,  Vinicius Barros Ribeiro da Silva

IPC: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

CPC classification number: C07D487/04 ,  A61K31/519 ,  A61K31/551 ,  A61K45/06

Abstract: The present disclosure is concerned with 9-hydroxy-6-(pyrrolidin-2-yl)-3, 4-dihydro-2H-pyrazino[1,2-c]pyrimidine-1,8-dione compounds for the treatment of various viral infections such as, for example, influenza virus. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

公开(公告)号：US20240159784A1

公开(公告)日：2024-05-16

申请号：US18389930

申请日：2023-12-20

Applicant: SRI International

Inventor： Nathan Collins ,  Jeremiah Malerich ,  Jason D. White ,  Kevin Luebke ,  Kristina Rucker ,  Brian McCoy

IPC: G01N35/00 ,  B01J19/00 ,  G01N35/04 ,  G01N35/10 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70

CPC classification number: G01N35/00613 ,  B01J19/0046 ,  G01N35/00871 ,  G01N35/04 ,  G01N35/1002 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00698 ,  G01N2035/00346 ,  G01N2035/0403 ,  G01N2035/0496

Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

公开(公告)号：US11885822B2

公开(公告)日：2024-01-30

申请号：US16626495

申请日：2018-06-29

Applicant: SRI International

Inventor： Nathan Collins ,  Jeremiah Malerich ,  Jason D. White ,  Kevin Luebke ,  Kristina Rucker ,  Brian McCoy

IPC: G01N35/10 ,  G01N35/00 ,  G01N35/04 ,  B01J19/00 ,  G16C20/10 ,  G16C20/70 ,  G16C10/00

CPC classification number: G01N35/00613 ,  B01J19/0046 ,  G01N35/00871 ,  G01N35/04 ,  G01N35/1002 ,  G16C10/00 ,  G16C20/10 ,  G16C20/70 ,  B01J2219/00344 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00689 ,  B01J2219/00693 ,  B01J2219/00695 ,  B01J2219/00698 ,  G01N2035/00346 ,  G01N2035/0403 ,  G01N2035/0496

Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

公开(公告)号：US20210065851A1

公开(公告)日：2021-03-04

申请号：US16965222

申请日：2019-01-30

Applicant: SRI INTERNATIONAL

Inventor： Peter Madrid ,  Nathan Collins ,  Mario Latendresse ,  Jeremiah Malerich ,  Markus Krummenacker

IPC: G16C20/70 ,  G16C10/00 ,  G16C20/10 ,  G16C20/80

Abstract: Retrosynthetic methods are described for determining one or more optimal synthetic routes to generate a target compound.

公开(公告)号：US20200316552A1

公开(公告)日：2020-10-08

申请号：US16496834

申请日：2018-04-06

Applicant: SRI INTERNATIONAL

Inventor： Jin-Ping Lim ,  David Stout ,  Nathan Collins ,  Jason D. White ,  Jeremiah Malerich

IPC: B01J19/00 ,  B01J19/24 ,  G16C20/10 ,  G01N21/75 ,  G01N21/25

Abstract: Disclosed are modular chemical reaction systems and methods of using such chemical reaction systems. The disclosed systems can have a substrate layer and a plurality of modules selectively mounted to an outer surface of the substrate layer. The substrate layer can include flow connectors that cooperate with the modules to form a fluid flow pathway for performing at least one step of a chemical reaction. At least one of the modules can be a process module, such as a reactor or separator. The modules can also include at least one regulator module. The system can also include at least one analysis device that analyzes at least one characteristic of the chemical reaction as the reaction occurs. The system can also include processing circuitry that monitors and/or optimizes the chemical reaction based on feedback received from the analysis device or other system components.

公开(公告)号：US20200225251A1

公开(公告)日：2020-07-16

申请号：US16626495

申请日：2018-06-29

Applicant: SRI International

Inventor： Nathan Collins ,  Jeremiah Malerich ,  Jason D. White ,  Kevin Luebke ,  Kristina Rucker

IPC: G01N35/00 ,  G01N35/10 ,  G01N35/04 ,  B01J19/00

Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.