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    MODULAR SYSTEMS FOR PERFORMING MULTISTEP CHEMICAL REACTIONS, AND METHODS OF USING SAME
    2.
    发明申请
    MODULAR SYSTEMS FOR PERFORMING MULTISTEP CHEMICAL REACTIONS, AND METHODS OF USING SAME 审中-公开

    公开(公告)号：US20200316552A1

    公开(公告)日：2020-10-08

    申请号：US16496834

    申请日：2018-04-06

    Applicant: SRI INTERNATIONAL

    Inventor： Jin-Ping Lim ,  David Stout ,  Nathan Collins ,  Jason D. White ,  Jeremiah Malerich

    IPC: B01J19/00 ,  B01J19/24 ,  G16C20/10 ,  G01N21/75 ,  G01N21/25

    Abstract: Disclosed are modular chemical reaction systems and methods of using such chemical reaction systems. The disclosed systems can have a substrate layer and a plurality of modules selectively mounted to an outer surface of the substrate layer. The substrate layer can include flow connectors that cooperate with the modules to form a fluid flow pathway for performing at least one step of a chemical reaction. At least one of the modules can be a process module, such as a reactor or separator. The modules can also include at least one regulator module. The system can also include at least one analysis device that analyzes at least one characteristic of the chemical reaction as the reaction occurs. The system can also include processing circuitry that monitors and/or optimizes the chemical reaction based on feedback received from the analysis device or other system components.

    APPARATUSES FOR REACTION SCREENING AND OPTIMIZATION, AND METHODS THEREOF
    3.
    发明申请
    APPARATUSES FOR REACTION SCREENING AND OPTIMIZATION, AND METHODS THEREOF 审中-公开

    公开(公告)号：US20200225251A1

    公开(公告)日：2020-07-16

    申请号：US16626495

    申请日：2018-06-29

    Applicant: SRI International

    Inventor： Nathan Collins ,  Jeremiah Malerich ,  Jason D. White ,  Kevin Luebke ,  Kristina Rucker

    IPC: G01N35/00 ,  G01N35/10 ,  G01N35/04 ,  B01J19/00

    Abstract: Embodiments in accordance with the present disclosure are directed to apparatuses used for reaction screening and optimization purposes. An example apparatus includes a plurality of reaction vessels, a dispensing subsystem, at least one reactor module, an analysis subsystem, an automation subsystem, and control circuitry. The dispensing subsystem delivers reagents to the plurality of reaction vessels for a plurality of reaction mixtures having varied reaction conditions. The at least one reactor module drives a plurality of reactions within the plurality of reaction vessels. The analysis subsystem analyzes compositions contained in the plurality of reaction vessels. The automation subsystem selectively moves the plurality of reaction vessels from a location proximal to the dispensing subsystem to the at least one reactor module based on experimental design parameters. And, the control circuitry identifies optimum reaction conditions for a target end product based on the analysis.

    MASS SPECTROMETRY DISTINGUISHABLE SYNTHETIC COMPOUNDS, LIBRARIES, AND METHODS THEREOF
    9.
    发明申请
    MASS SPECTROMETRY DISTINGUISHABLE SYNTHETIC COMPOUNDS, LIBRARIES, AND METHODS THEREOF 有权

    公开(公告)号：US20210065848A1

    公开(公告)日：2021-03-04

    申请号：US16644565

    申请日：2017-09-05

    Applicant: SRI International

    Inventor： Peter Madrid ,  Nathan Collins ,  Michal Avital-Shmilovici ,  Pauline Bourbon ,  Thomas Shaler

    IPC: G16C20/20 ,  G16C20/62 ,  G16C20/64

    Abstract: Embodiments in accordance with the present disclosure are directed to polymer beads and uses thereof, including forming libraries of compounds for screening and assay purposes. An example method includes using logic circuitry to: select a plurality of molecules that include a plurality of subgroups, each of the plurality of molecules exhibiting a mass spectrometry characteristic that is distinguishable from mass spectrometry characteristics of other molecules of the plurality, and assign the plurality of molecules with a position in a sequence of a plurality of synthetic compounds forming a library. The method further includes defining, as data in a memory circuit of the logic circuitry, the plurality of synthetic compounds that are sequenceable via mass spectrometry using the assigned positions of the plurality of molecules for communicating to other circuitry for formation thereof via coupling chemistry or screening of a particular function.

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