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公开(公告)号：US09870909B2
公开(公告)日：2018-01-16
申请号：US14739826
申请日：2015-06-15
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/16 , H01J49/0095 , H01J49/0418
Abstract: The invention provides ionizing matrix compounds. These compounds are useful for mass spectrometry and ion mobility spectrometry as ionizing matrices facilitating transfer of diverse classes of analyte compounds from solid or solution states to gas-phase ions.
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2.发明授权Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum 有权将激光喷射电离质谱概念从大气压力扩展到真空的系统和方法公开(公告)号：US09177773B2
公开(公告)日：2015-11-03
申请号：US14477726
申请日：2014-09-04
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/164 , G01N27/622 , H01J49/165 , H01J49/24 , H01J49/40
Abstract: Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry.
Abstract translation: 本文公开了允许使用具有或不具有改性和加热的市售质谱仪在中压或高真空下使用激光喷射电离分析大分子结构的系统和方法。 该系统和方法产生多重带电离子，以改进质谱分析。
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公开(公告)号：US10679838B2
公开(公告)日：2020-06-09
申请号：US15330635
申请日：2016-10-20
Applicant: Sarah Trimpin , Ellen dela Victoria Inutan
Inventor： Sarah Trimpin , Ellen dela Victoria Inutan
Abstract: An ionization method for use with mass spectrometry or ion mobility spectrometry is a small molecule compound(s) as a matrix into which is incorporated analyte. The matrix has attributes of sublimation or evaporation when placed in vacuum at or near room temperature and produces both positive and negative charges. Placing the sample into a region of sub-atmospheric pressure, the region being in fluid communication with the vacuum of the mass spectrometer or ion mobility spectrometer, produces gas-phase ions of the analyte for mass-to-charge or drift-time analysis without use of a laser, high voltage, particle bombardment, or a heated ion transfer region. This matrix and vacuum assisted ionization process can operate from atmosphere or vacuum and produces ions from large (e.g. proteins) and small molecules (e.g. drugs) with charge states similar to those observed in electrospray ionization.
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公开(公告)号：US09202680B2
公开(公告)日：2015-12-01
申请号：US13376132
申请日：2010-06-03
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/044 , H01J27/24 , H01J49/0468 , H01J49/164
Abstract: Disclosed herein are systems and methods for mass spectrometry using laserspray ionization (LSI). LSI can create multiply-charged ions at atmospheric pressure for analysis and allows for analysis of high molecular weight molecules including molecules over 4000 Daltons. The analysis can be solvent-based or solvent-free. Solvent-free analysis following LSI allows for improved spatial resolution beneficial in surface and/or tissue imaging.
Abstract translation: 本文公开了使用激光喷射电离（LSI）的质谱的系统和方法。 LSI可以在大气压下产生多电荷离子进行分析，并允许分析高分子量分子，包括超过4000道尔顿的分子。 分析可以是溶剂型或无溶剂型。 在LSI之后的无溶剂分析允许有利于表面和/或组织成像的改善的空间分辨率。
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5.发明申请SYSTEMS AND METHODS EXTENDING THE LASERSPRAY IONIZATION MASS SPECTROMETRY CONCEPT FROM ATMOSPHERIC PRESSURE TO VACUUM 有权将大气压力扩展到真空的LASERSPRAY离子质谱仪的系统和方法公开(公告)号：US20150053854A1
公开(公告)日：2015-02-26
申请号：US14477726
申请日：2014-09-04
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/164 , G01N27/622 , H01J49/165 , H01J49/24 , H01J49/40
Abstract: Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry.
Abstract translation: 本文公开了允许使用具有或不具有改性和加热的市售质谱仪在中压或高真空下使用激光喷射电离分析大分子结构的系统和方法。 该系统和方法产生多重带电离子，以改进质谱分析。
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Patent Agency Ranking
6.发明授权System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry 有权用于质谱离子化和离子迁移谱分析的系统和方法公开(公告)号：US09552973B2
公开(公告)日：2017-01-24
申请号：US13819487
申请日：2011-09-01
Applicant: Charles Nehemiah McEwen , Sarah Trimpin , Vincent Salvatore Pagnotti
Inventor： Charles Nehemiah McEwen , Sarah Trimpin , Vincent Salvatore Pagnotti
CPC classification number: H01J49/10 , H01J49/0404 , H01J49/0468
Abstract: An ionizing system includes a channel having an inlet disposed in a first pressure region and an outlet disposed in a second pressure region, a pressure of the first pressure region being greater than a pressure of the second pressure region. A heater is coupled to the channel and configured to heat the channel. A device is configured to introduce an analyte into the channel where the analyte is ionized.
Abstract translation: 电离系统包括具有设置在第一压力区域中的入口和设置在第二压力区域中的出口的通道，第一压力区域的压力大于第二压力区域的压力。 加热器耦合到通道并且被配置为加热通道。 一种装置被配置为将分析物引入分析物被离子化的通道中。
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7.发明申请SYSTEMS AND METHODS FOR HIGH THROUGHPUT SOLVENT ASSISTED IONIZATION INLET FOR MASS SPECTROMETRY 有权用于大量光谱的高通量溶剂辅助离子入口的系统和方法公开(公告)号：US20160284528A1
公开(公告)日：2016-09-29
申请号：US15181300
申请日：2016-06-13
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/0468 , H01J49/04 , H01J49/10 , H01J49/24
Abstract: A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.
Abstract translation: 使用溶剂辅助电离入口实现样品的高通量分析的多路复用系统和方法包括具有加热入口通道和跨入口通道的压力差的离子化系统，与质谱仪的入口串联对准的移液管尖端，以及系统 通过质谱法生成的测绘数据。
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公开(公告)号：US20150364311A1
公开(公告)日：2015-12-17
申请号：US14739826
申请日：2015-06-15
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/16 , H01J49/0095 , H01J49/0418
Abstract: The invention provides ionizing matrix compounds. These compounds are useful for mass spectrometry and ion mobility spectrometry as ionizing matrices facilitating transfer of diverse classes of analyte compounds from solid or solution states to gas-phase ions.
Abstract translation: 本发明提供电离基质化合物。 这些化合物可用于质谱和离子迁移谱分析，作为促进不同类别的分析物从固体或溶液状态转移到气相离子的离子化基质。
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9.发明授权Systems and methods extending the laserspray ionization mass spectrometry concept from atmospheric pressure to vacuum 有权将激光喷射电离质谱概念从大气压力扩展到真空的系统和方法公开(公告)号：US08853621B2
公开(公告)日：2014-10-07
申请号：US13881684
申请日：2011-10-25
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/164 , G01N27/622 , H01J49/165 , H01J49/24 , H01J49/40
Abstract: Disclosed herein are systems and methods that allow analysis of macromolecular structures using laserspray ionization at intermediate pressure or high vacuum using commercially available mass spectrometers with or without modification and with the application of heat. The systems and methods produce multiply-charged ions for improved analysis in mass spectrometry.
Abstract translation: 本文公开了允许使用具有或不具有改性和加热的市售质谱仪在中压或高真空下使用激光喷射电离分析大分子结构的系统和方法。 该系统和方法产生多重带电离子，以改进质谱分析。
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10.发明申请公开(公告)号：US20170213714A9
公开(公告)日：2017-07-27
申请号：US15181300
申请日：2016-06-13
Applicant: Sarah Trimpin
Inventor： Sarah Trimpin
CPC classification number: H01J49/0468 , H01J49/04 , H01J49/10 , H01J49/24
Abstract: A multiplex system and method for achieving high throughput analysis of samples using solvent assisted ionization inlet includes an ionizing system with a heated inlet channel and a pressure differential across the inlet channel, pipet tips serially aligned with the inlet to a mass spectrometer, and a system of mapping data generated by mass spectrometry.
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