公开(公告)号：US11872412B2

公开(公告)日：2024-01-16

申请号：US16112150

申请日：2018-08-24

Applicant: Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

Inventor： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC: A61N7/00 ,  A61N7/02 ,  A61B90/00

CPC classification number: A61N7/00 ,  A61N7/02 ,  A61B2090/374 ,  A61N2007/0073 ,  A61N2007/0078

Abstract: A system and method for selecting a patient-specific frequency for ultrasound therapy of a target within the patient are provided. The method includes: (a) for at least one segment of an ultrasound transducer and for each of a plurality of ultrasound frequencies within a test range, sonicating the target and measuring a parameter correlated with an amount of ultrasound energy absorbed in the target; and (b) for each said at least one segment, selecting for subsequent ultrasound therapy, among the frequencies within the test range, a frequency corresponding to a value of the measured parameter that itself corresponds to a maximum amount of ultrasound energy absorbed in the target.

公开(公告)号：US10449395B2

公开(公告)日：2019-10-22

申请号：US13323070

申请日：2011-12-12

Applicant: Shuki Vitek ,  Yoav Medan ,  Yoav Levy

Inventor： Shuki Vitek ,  Yoav Medan ,  Yoav Levy

IPC: A61N7/02 ,  A61B8/08 ,  A61B8/00 ,  A61B5/055 ,  G01R33/48 ,  A61B5/113 ,  A61B5/00 ,  A61N7/00 ,  A61B90/00

Abstract: A method for transcostal ultrasound treatment of tissues includes determining rib locations, e.g., based on ultrasound reflections off the ribs or acoustic radiation force signals, and transcostally focusing ultrasound into the tissue while minimizing damage to the ribs.

公开(公告)号：US20190009109A1

公开(公告)日：2019-01-10

申请号：US16112150

申请日：2018-08-24

Applicant: Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

Inventor： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario

IPC: A61N7/00

Abstract: In ultrasound therapy, the frequency of sonications can be optimized, within a certain frequency range, to maximize the absorption or the acoustic intensity at the target in a manner specific to the patient.

公开(公告)号：US20130150756A1

公开(公告)日：2013-06-13

申请号：US13323070

申请日：2011-12-12

Applicant: Shuki Vitek ,  Yoav Medan ,  Yoav Levy

Inventor： Shuki Vitek ,  Yoav Medan ,  Yoav Levy

IPC: A61N7/00

CPC classification number: A61N7/02 ,  A61B5/0035 ,  A61B5/055 ,  A61B5/113 ,  A61B5/4836 ,  A61B8/0875 ,  A61B8/4416 ,  A61B8/4483 ,  A61B8/485 ,  A61B8/5207 ,  A61B2090/374 ,  A61B2090/378 ,  A61N2007/0052 ,  A61N2007/0078 ,  A61N2007/0095 ,  A61N2007/027 ,  G01R33/4814

Abstract: A method for transcostal ultrasound treatment of tissues includes determining rib locations, e.g., based on ultrasound reflections off the ribs or acoustic radiation force signals, and transcostally focusing ultrasound into the tissue while minimizing damage to the ribs.

Abstract translation: 用于经肋超声处理组织的方法包括确定肋位置，例如基于离开肋的超声反射或声辐射力信号，以及将超声波聚焦到组织中，同时最小化对肋的损伤。

公开(公告)号：US20130150704A1

公开(公告)日：2013-06-13

申请号：US13323073

申请日：2011-12-12

Applicant: Shuki Vitek ,  Yoav Medan ,  Yoav Levy

Inventor： Shuki Vitek ,  Yoav Medan ,  Yoav Levy

IPC: A61B6/00

CPC classification number: A61B5/055 ,  A61B5/0035 ,  A61B5/4538 ,  A61B6/032 ,  A61N7/02 ,  G01R33/4814 ,  G01R33/4835

Abstract: A method for spatially localizing a rib cage prior to transcostal ultrasound treatment of visceral tissue includes computationally refining a three-dimensional model of the rib cage based on image slices taken at multiple locations along the ribs with orientations dependent on local rib orientations.

Abstract translation: 在内脏组织的经肋超声处理之前空间定位肋骨的方法包括基于沿着沿着肋的多个位置拍摄的图像切片来计算地改进肋骨架的三维模型，其取向取决于局部肋取向。

公开(公告)号：US08235901B2

公开(公告)日：2012-08-07

申请号：US11536619

申请日：2006-09-28

Applicant: Rita Schmidt ,  Shuki Vitek

Inventor： Rita Schmidt ,  Shuki Vitek

IPC: A61B8/00

CPC classification number: A61N7/02 ,  A61B2017/00176 ,  A61B2017/22008 ,  A61B2090/374

Abstract: A method for treating body tissue using acoustic energy includes identifying a target focal zone of tissue to be treated, delivering a first pulse of acoustic energy from a transducer to generate bubbles in a tissue region located distally, relative to the transducer, of a focal center of the target focal zone, and delivering a second pulse of acoustic energy from the transducer in the presence of the bubbles generated by the first pulse, the second pulse focused at the focal center to generate thermal ablation energy. In a further embodiment, a method of treating body tissue using ultrasound energy includes identifying a target focal zone to be treated and delivering a plurality of pulses of acoustic ablation energy to locations distributed symmetrically in or proximate a focal plane about the focal center of the target focal zone.

Abstract translation: 使用声能来治疗身体组织的方法包括识别要治疗的组织的目标聚焦区域，从换能器输送第一声学能量脉冲，以在相对于换能器的远端位于组织区域中的中心位置产生气泡 并且在存在由第一脉冲产生的气泡的情况下传送来自换能器的第二脉冲声能，第二脉冲聚焦在焦点中心以产生热消融能量。 在另一实施例中，使用超声能量治疗身体组织的方法包括识别待治疗的目标聚焦区域，并将多个声学消融能量的脉冲递送到围绕靶标的焦点中心对称地分布在焦平面附近的位置 焦点区。

公开(公告)号：US20120071746A1

公开(公告)日：2012-03-22

申请号：US13238743

申请日：2011-09-21

Applicant: Kobi Vortman ,  David Freundlich ,  Shuki Vitek

Inventor： Kobi Vortman ,  David Freundlich ,  Shuki Vitek

IPC: A61B5/055

CPC classification number: G01R33/4804 ,  G01R33/4814

Abstract: During the thermal treatment of an anatomical zone of interest, tissue temperature within the zone may be determined with a computational model whose parameters are adjusted using spectroscopy-based temperature measurements at interfaces of fat and non-fat tissues.

Abstract translation: 在感兴趣的解剖区域的热处理期间，区域内的组织温度可以用计算模型确定，其计算模型的参数使用基于脂肪和非脂肪组织的界面处的基于光谱的温度测量进行调整。

公开(公告)号：US20110046472A1

公开(公告)日：2011-02-24

申请号：US12543951

申请日：2009-08-19

Applicant: Rita Schmidt ,  Hadas Ziso ,  Benny Assif ,  Osnat Dogadkin ,  David Freundlich ,  Yoav Levy ,  Shuki Vitek

Inventor： Rita Schmidt ,  Hadas Ziso ,  Benny Assif ,  Osnat Dogadkin ,  David Freundlich ,  Yoav Levy ,  Shuki Vitek

IPC: A61B5/055 ,  A61N7/00

CPC classification number: A61B5/055 ,  A61N2007/0004 ,  G01R33/4804 ,  G01R33/56509 ,  G01R33/56563

Abstract: Techniques for temperature measurement and correction in long-term MR thermometry utilize a known temperature distribution in an MR imaging area as a baseline for absolute temperature measurement. Phase shifts that arise from magnetic field drifts are detected in one or more portions of the MR imaging area, facilitating correction of temperature measurements in an area of interest.

Abstract translation: 用于长期MR测温的温度测量和校正技术利用MR成像区域中已知的温度分布作为绝对温度测量的基线。 在MR成像区域的一个或多个部分中检测出由磁场漂移产生的相移，有助于校正感兴趣区域中的温度测量。

公开(公告)号：US06506171B1

公开(公告)日：2003-01-14

申请号：US09626176

申请日：2000-07-27

Applicant: Shuki Vitek ,  Naama Brenner

Inventor： Shuki Vitek ,  Naama Brenner

IPC: A61H100

CPC classification number: G10K11/346 ,  A61H23/0245 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0095 ,  A61N2007/027

Abstract: A focused ultrasound system includes a plurality of transducer elements disposed about and having an angular position with a central axis. Drive signals drive respective transducer elements that include phase shift values based upon the angular position of each respective transducer element. The phase shift values are based upon an oscillation function that oscillates about the central axis between minimal and maximal phase shift values such that a first on-axis focal zone and a second off-axis focal zone are created. An amplitude and frequency of the oscillation function are controlled to adjust relative acoustic energy levels of the first and second focal zones, and to adjust a radius of the second focal zone, respectively. In addition, the drive signals include an additional predetermined phase shift based upon a radial position of each respective transducer element to adjust a focal distance of the focal zones.

Abstract translation: 聚焦超声系统包括围绕中心轴设置并具有角位置的多个换能器元件。 驱动信号根据每个相应换能器元件的角位置驱动包括相移值的各个换能器元件。 相移值基于在最小和最大相移值之间围绕中​​心轴振荡的振荡函数，使得产生第一轴上焦点区域和第二离轴焦点区域。 控制振荡功能的幅度和频率以调整第一和第二焦点区域的相对声能级，并分别调整第二聚焦区域的半径。 此外，驱动信号包括基于每个相应换能器元件的径向位置的附加预定相移，以调整焦点区域的焦距。

公开(公告)号：US11103731B2

公开(公告)日：2021-08-31

申请号：US15404412

申请日：2017-01-12

Applicant: Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

Inventor： Kobi Vortman ,  Shuki Vitek ,  Eyal Zadicario ,  Yoav Levy

IPC: A61N7/02 ,  A61B5/055 ,  A61B8/08 ,  A61N7/00 ,  A61B18/00 ,  A61B90/00

Abstract: Various approaches for heating a target region substantially uniformly include identifying one or more locations of one or more hot spots in the target region and/or surrounding regions of the target region during an ultrasound sonication process; computing a temporal variation to an output parameter of at least one of the transducer elements based at least in part on the identified location(s) of the hot spot(s); and operating the at least one transducer element to achieve the temporal variation of the output parameter so as to minimize the hot spot(s).