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公开(公告)号：US20190010196A1
公开(公告)日：2019-01-10
申请号：US16073501
申请日：2017-01-31
Inventor： Daniel Durocher , Sachdev Sidhu , Wei Zhang , Frank Sicheri , Marella Canny
IPC: C07K14/47 , C12N15/62 , C12N15/113 , C12N9/22
Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
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公开(公告)号：US11261466B2
公开(公告)日：2022-03-01
申请号：US15554042
申请日：2016-03-01
Applicant: Sinai Health System
Inventor： Daniel Durocher , Alexandre Orthwein , Sylvie Noordermeer
IPC: C12N15/00 , C12N15/09 , C12N15/113 , C07K14/47 , C12N15/90 , A61K31/713 , C12N15/10 , C12Q1/6886 , C12N15/63 , C12N9/00 , C12N15/67
Abstract: The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for agents that modulate homologous recombination, and methods to activate or modulate homologous recombination.
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Patent Agency Ranking
公开(公告)号：US10808017B2
公开(公告)日：2020-10-20
申请号：US16073501
申请日：2017-01-31
Inventor： Daniel Durocher , Sachdev Sidhu , Wei Zhang , Frank Sicheri , Marella Canny
Abstract: 53BP1 inhibitors, compositions comprising the inhibitors and methods of using same are provided. The inhibitors can be used in combination with gene editing systems.
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公开(公告)号：US20180073039A1
公开(公告)日：2018-03-15
申请号：US15554042
申请日：2016-03-01
Applicant: Sinai Health System
Inventor： Daniel Durocher , Alexandre Orthwein , Sylvie Noordermeer
IPC: C12N15/90 , A61K31/713 , C12N15/10 , C12N15/113 , C07K14/47 , C12N15/67 , C12Q1/68
CPC classification number: C12N15/902 , A61K31/713 , C07K14/47 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/102 , C12N15/113 , C12N15/1138 , C12N15/63 , C12N15/67 , C12N15/90 , C12N2310/14 , C12N2310/141 , C12N2310/20 , C12N2310/531 , C12N2800/80 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
Abstract: The invention relates to factors that influence or regulate homologous recombination, methods to monitor these factors, the use of these factors to screen for agents that modulate homologous recombination, and methods to activate or modulate homologous recombination.
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公开(公告)号：US20240352081A1
公开(公告)日：2024-10-24
申请号：US18426877
申请日：2024-01-30
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
CPC classification number: C07K14/4703 , A61P35/00 , A61K38/00
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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公开(公告)号：US11897925B2
公开(公告)日：2024-02-13
申请号：US17520638
申请日：2021-11-06
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
CPC classification number: C07K14/4703 , A61P35/00 , A61K38/00
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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公开(公告)号：US20220153793A1
公开(公告)日：2022-05-19
申请号：US17520638
申请日：2021-11-06
Applicant: Sinai Health System
Inventor： Daniel Durocher , Salomé Adam , Silvia Emma Rossi , Yibo Xue
Abstract: Disclosed are compounds, compositions, uses and methods using inhibitors of the CIP2A-TOPBP1 complex or agents that inhibit phosphopeptide recognition of TOPBP1 BRCT7/8, for treatment of a cancer associated with or characterized by a homologous recombination (HR) deficiency or treatment of cancer cells having HR deficiency.
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