公开(公告)号：US12087568B2

公开(公告)日：2024-09-10

申请号：US18456678

申请日：2023-08-28

Applicant: Standard BioTools Canada Inc.

Inventor： Alexander Loboda ,  Raymond Jong ,  Michael Sullivan ,  Serguei Vorobiev ,  Robert Rotenberg ,  Emil D. Stratulativ ,  Maxim Voronov ,  Mark Armstrong

IPC: H01J49/00 ,  H01J49/04 ,  H01J49/10 ,  H05H1/24 ,  H05H1/30

CPC classification number: H01J49/105 ,  H01J49/0027 ,  H01J49/0463 ,  H05H1/2406 ,  H05H1/30

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.

公开(公告)号：US20240369566A1

公开(公告)日：2024-11-07

申请号：US18752407

申请日：2024-06-24

Applicant: Standard BioTools Canada Inc.

Inventor： Alexander Loboda ,  Raymond Jong ,  Michael Sullivan ,  Serguei Vorobiev ,  Robert Rotenberg ,  Emil D. Stratulativ ,  Maxim Voronov ,  Mark Armstrong

IPC: G01N33/58 ,  C12M3/06

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.

公开(公告)号：US20240361304A1

公开(公告)日：2024-10-31

申请号：US18657098

申请日：2024-05-07

Applicant: Standard BioTools Canada Inc.

Inventor： Vladimir Baranov ,  Alexander Loboda ,  Michael Sullivan

IPC: G01N33/53 ,  G01N33/58 ,  H01J49/10

CPC classification number: G01N33/5306 ,  G01N33/58 ,  H01J49/105 ,  G01N2458/15 ,  G01N2560/00

Abstract: Analyzing samples injected into an inductively coupled plasma source can be improved by one or more of a stabilizing solution mixable with a sample prior to injection and a heated injector. The stabilizing solution can minimize the difference in osmotic pressure between the solution and the cells with a relatively low amount of dissolved solids (e.g., at or below about 0.2%). The stabilizing solution can contain a salt (e.g., ammonium nitrate) present in concentrations of at least 5 mM. The injector can be heated before and/or during injection. In some cases, heat from adjacent parts can be channeled into the injector to improve heating of the injector. An injector heated to sufficient temperatures can minimize solute buildup and can extend the usable time between cleanings. These improvements can be especially useful in elemental analysis, such as inductively coupled plasma mass spectrometry or inductively coupled plasma optical emission spectrometry.

公开(公告)号：US20230411136A1

公开(公告)日：2023-12-21

申请号：US18456678

申请日：2023-08-28

Applicant: Standard BioTools Canada Inc.

Inventor： Alexander Loboda ,  Raymond Jong ,  Michael Sullivan ,  Serguei Vorobiev ,  Robert Rotenberg ,  Emil D. Stratulativ ,  Maxim Voronov ,  Mark Armstrong

IPC: H01J49/10 ,  H01J49/00 ,  H05H1/30 ,  H05H1/24 ,  H01J49/04

CPC classification number: H01J49/105 ,  H01J49/0027 ,  H01J49/0463 ,  H05H1/2406 ,  H05H1/30

Abstract: Inductively coupled plasma (ICP) analyzers use an ICP torch to generate a plasma in which a sample is atomized an ionized. Analysis of the atomic ions can be performed by atomic analysis, such as mass spectrometry (MS) or atomic emission spectrometry (AES). Particle based ICP analysis includes analysis of particles such as cells, beads, or laser ablation plumes, by atomizing and ionizing particles in an ICP torch followed by atomic analysis. In mass cytometry, mass tags of particles are analyzed by mass spectrometry, such as by ICP-MS. Systems and methods of the subject application include one or more of: a demountable ICP torch holder assembly, an external ignition device; an ICP load coil comprising an annular fin, particle suspension sample introduction fluidics, and ICP analyzers thereof.