公开(公告)号：US11471098B2

公开(公告)日：2022-10-18

申请号：US16749025

申请日：2020-01-22

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: A61B5/05 ,  A61B5/00 ,  C12Q1/6883 ,  A61B5/055

Abstract: Systems and methods are provided for monitoring the effects of therapeutics on the brain. Brains of first and second sets of patients are imaged and a gene expression is measured at a first time to provide a first set of images and a first set of gene expression transcripts. A therapeutic is administered to the first set of patients after the first time. The brains of the patients are imaged and the gene expression of the patients is measured at a second time, after the therapeutic is administered, to provide a second set of images and a second set of gene expression transcripts. A change in the brain is determined for the patients from the sets of images. A set of changes in the gene expression that are correlated with the changes in the brain are determined from the change in the brain and the sets of gene expression transcripts.

公开(公告)号：US10890639B2

公开(公告)日：2021-01-12

申请号：US16413896

申请日：2019-05-16

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: G01V3/00 ,  G01R33/48 ,  C12Q1/6876 ,  A61B5/055 ,  A61B5/00

Abstract: Systems and methods are provided for correlating functional magnetic resonance imaging (fMRI) with gene expression. Brains of first and second sets of patients are imaged at first and second times to provide first and second sets of fMRI images. Blood is drawn from each of the first and second sets of patients at the first and second times to provide first and second sets of gene expression transcripts. A therapeutic is administered to the first set of patients between the first and second times. A change in the connectivity of the brain for each patient is determined from the first and second sets of fMRI images. A set of changes in the peripheral lymphocyte gene expression that are correlated with changes in the connectivity of the brain are determined from the change in the connectivity of the brain for each patient and the collected imaging and gene expression data.

公开(公告)号：US20190353729A1

公开(公告)日：2019-11-21

申请号：US16413896

申请日：2019-05-16

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: G01R33/48 ,  C12Q1/6876 ,  A61B5/00 ,  A61B5/055

Abstract: Systems and methods are provided for correlating functional magnetic resonance imaging (fMRI) with gene expression. Brains of first and second sets of patients are imaged at first and second times to provide first and second sets of fMRI images. Blood is drawn from each of the first and second sets of patients at the first and second times to provide first and second sets of gene expression transcripts. A therapeutic is administered to the first set of patients between the first and second times. A change in the connectivity of the brain for each patient is determined from the first and second sets of fMRI images. A set of changes in the peripheral lymphocyte gene expression that are correlated with changes in the connectivity of the brain are determined from the change in the connectivity of the brain for each patient and the collected imaging and gene expression data.

公开(公告)号：US20220175692A1

公开(公告)日：2022-06-09

申请号：US17545190

申请日：2021-12-08

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: A61K31/02 ,  A61K31/4453 ,  A61K33/00 ,  A61K31/05 ,  A61K31/53 ,  A61K31/428 ,  A61K31/381 ,  A61K31/55 ,  A61K31/4166

Abstract: A method of anesthetizing a subject that includes administering a therapeutically effective amount of an NMDA antagonist to the subject is described. The method also includes administering an effective amount of a presynaptic glutamate release inhibitor to the subject to decrease the neurotoxic and/or psychomimetic side effects of the NMDA antagonist. Pharmaceutical compositions including an NMDA antagonist and a presynaptic glutamate release inhibitor are also described.

公开(公告)号：US20200155062A1

公开(公告)日：2020-05-21

申请号：US16749025

申请日：2020-01-22

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Amit Anand

IPC: A61B5/00 ,  A61B5/055 ,  C12Q1/6883

Abstract: Systems and methods are provided for monitoring the effects of therapeutics on the brain. Brains of first and second sets of patients are imaged and a gene expression is measured at a first time to provide a first set of images and a first set of gene expression transcripts. A therapeutic is administered to the first set of patients after the first time. The brains of the patients are imaged and the gene expression of the patients is measured at a second time, after the therapeutic is administered, to provide a second set of images and a second set of gene expression transcripts. A change in the brain is determined for the patients from the sets of images. A set of changes in the gene expression that are correlated with the changes in the brain are determined from the change in the brain and the sets of gene expression transcripts.