公开(公告)号：US20210272661A1

公开(公告)日：2021-09-02

申请号：US17187782

申请日：2021-02-27

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Daniel M. Rotroff ,  Kevin M. Pantalone ,  Galen Miller-Atkins ,  Arshiya Mariam

IPC: G16H10/40 ,  G16H15/00 ,  G16B50/30 ,  G16H10/60 ,  G16H50/30

Abstract: Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score

公开(公告)号：US20220095949A1

公开(公告)日：2022-03-31

申请号：US17429078

申请日：2020-02-06

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Daniela S. Allende ,  Federico N. Aucejo ,  Daniel M. Rotroff

IPC: A61B5/08 ,  A61B5/00 ,  G01N33/00 ,  G01N33/497

Abstract: A method for diagnosing a subject with one or more of hepatocellular carcinoma (HCC), chronic liver disease, colorectal liver metastases (CRLM), and pulmonary hypertension is described. The method includes obtaining a breath sample from a subject, analyzing the breath sample obtained from the subject to determine one or more breath metabolite abundance values, inputting one or more of the breath metabolite abundance values into a machine-learning-model, and assigning a clinical parameter to the subject representing the likelihood that the subject has one or more of HCC, chronic liver disease, CRLM, and pulmonary hypertension.

公开(公告)号：US20250087318A1

公开(公告)日：2025-03-13

申请号：US18956213

申请日：2024-11-22

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Daniel M. Rotroff ,  Kevin M. Pantalone ,  Galen Miller-Atkins ,  Arshiya Mariam

IPC: G16H10/40 ,  G16B40/00 ,  G16H10/60 ,  G16H15/00 ,  G16H50/30

Abstract: Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score

公开(公告)号：US12205686B2

公开(公告)日：2025-01-21

申请号：US17187782

申请日：2021-02-27

Applicant: THE CLEVELAND CLINIC FOUNDATION

Inventor： Daniel M. Rotroff ,  Kevin M. Pantalone ,  Galen Miller-Atkins ,  Arshiya Mariam

IPC: G16H10/40 ,  G16B40/00 ,  G16H10/60 ,  G16H15/00 ,  G16H50/30

Abstract: Systems and methods are provided for assigning a treatment to a patient is provided. A set of genetic data representing a patient. A polygenic score representing the likelihood that a patient will benefit from intensive glycemia treatment is generated from the set of genetic data. A parameter representing a response of the patient to intensive glycemia treatment is assigned according to the polygenic score.