公开(公告)号：US10935552B2

公开(公告)日：2021-03-02

申请号：US15737187

申请日：2016-06-24

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Engui Zhao ,  Chen Gui ,  Meijuan Jiang ,  Haiqin Deng ,  Wai Tung Leung ,  Zhiming Wang ,  Yueyue Zhao ,  Tsz Kin Kwok ,  Lucia Viglianti ,  Ni Xie

IPC: C09K11/06 ,  G01N33/58 ,  C08G65/00 ,  A61K49/00 ,  A61K41/00 ,  A61K31/4706 ,  A61K31/47 ,  A61K33/22 ,  A61K31/5375 ,  A61K31/695 ,  C09B23/04 ,  C09B26/02 ,  C09B57/00

Abstract: The present subject matter relates to ATE luminogens for visualization and treatment of cancer, particularly AIE luminogenic probes for cancer cell visualization and discrimination, lysosome-targeting AIEgens for imaging and autophagy visualization, highly fluorescent AIE-active theranostic agents for monitoring drug distribution and having anti-tumor activity to specific cancer cells, probes comprising AIE luminogens for cancer cell imaging and staining, AIE luminogens having clusteroluminogenic features and applications thereof, and methods of preparing thereof.

公开(公告)号：US09315465B2

公开(公告)日：2016-04-19

申请号：US14164591

申请日：2014-01-27

Applicant: THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY

Inventor： Benzhong Tang ,  Yuning Hong ,  Sijie Chen ,  Wai Tung Leung ,  Engui Zhao ,  Haiqin Deng

IPC: G01N33/52 ,  C07D217/04 ,  C07F9/54 ,  C07D209/08 ,  A61K49/00

CPC classification number: C07D217/04 ,  A61K49/0023 ,  C07D209/08 ,  C07F9/5449 ,  G01N33/52

Abstract: AIE (aggregation-induced emission)-active TPE derivatives, TPE-TPP, TPE-MitoR and TPE-IQ are contemplated. These specific TPE derivatives are useful as fluorescent agents for mitochondrial imaging and as apoptosis inducers. Possessing high specificity to mitochondria, superior photostability and appreciable tolerance to microenvironment change, TPE derivatives are well-suited imaging agents for mitochondrial targeting and morphological change tracking. Because of their synthetic flexibility, TPE derivatives can be further modified as dual-functional probes for an array of applications such as sensing of ROS, metal ions, or pH change in mitochondria.

Abstract translation: 考虑了AIE（聚集诱发发射）活性TPE衍生物，TPE-TPP，TPE-MitoR和TPE-IQ。 这些特异性TPE衍生物可用作线粒体成像和凋亡诱导剂的荧光剂。 对线粒体具有高度的特异性，优异的光稳定性和对微环境变化的显着耐受性，TPE衍生物是用于线粒体靶向和形态学变化追踪的非常适合的成像剂。 由于其合成灵活性，TPE衍生物可进一步修改为用于应用阵列的双功能探针，例如感测ROS，金属离子或线粒体中的pH变化。