公开(公告)号：US11460395B2

公开(公告)日：2022-10-04

申请号：US16900838

申请日：2020-06-12

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Aniruddha Ray ,  Hyouarm Joung ,  Derek Tseng ,  Isidro B. Salusky

IPC: B01L3/00 ,  G01N21/01 ,  G01N21/25 ,  G01N33/49 ,  G01N21/78 ,  G01N21/17 ,  G01N21/84

Abstract: A portable colorimetric assay system includes an opto-mechanical reader configured to be detachably mounted to a mobile phone having a camera or other camera-containing portable electronic device. The opto-mechanical reader includes one or more light sources configured to illuminate a test sample holder and control sample holder disposed in the opto-mechanical reader along an optical path aligned with a camera of the mobile phone or other camera-containing portable electronic device. One or more serum separation membranes are disposed in the opto-mechanical reader and define a sample receiving pad configured to receive a blood sample. A moveable serum collection membrane is membrane is also disposed in the reader and is configured to contact the sample receiving pad in a first position and moveable to a second position where the serum collection membrane is disposed inside the test sample holder.

公开(公告)号：US10175215B2

公开(公告)日：2019-01-08

申请号：US15538309

申请日：2015-12-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Bingen Cortazar ,  Hatice Ceylan Koydemir ,  Derek Tseng ,  Steve Feng

IPC: G01N21/25 ,  G01N33/00 ,  H04Q9/00 ,  G01N21/27 ,  G01N21/31 ,  G06T7/90 ,  G06K9/00 ,  G06K9/46 ,  G06K9/62 ,  G01N21/84 ,  G01N21/01 ,  G06K9/20 ,  G06K9/22

Abstract: A system for measuring chlorophyll concentration in a leaf sample includes a leaf-holding illuminator device with a main body containing a power source, a plurality of switchable light sources emitting light at different spectra (e.g., red and white light from a broadband light source), and a cap detachably secured to the main body using one or more fastening means. The leaf sample is interposed between the main body and the cap and held in place during imaging. The system includes a mobile electronic device having a camera configured to capture an image of the leaf illuminated by the plurality of switchable light sources, the mobile electronic device having wireless connectivity to a network and an application contained therein configured to transfer the images to a remote sever or computer via the network for data processing. A final chlorophyll index value is calculated based on the transferred images.

公开(公告)号：US20180196193A1

公开(公告)日：2018-07-12

申请号：US15737743

申请日：2016-06-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Brandon Berg ,  Bingen Cortazar ,  Derek Tseng ,  Steve Wei Feng ,  Haydar Ozkan ,  Omai Garner ,  Dino Di Carlo

IPC: G02B6/06 ,  G01N21/25 ,  G06F15/18 ,  H04N5/225

CPC classification number: G02B6/06 ,  G01N21/253 ,  G01N2201/0221 ,  G01N2201/08 ,  G06N20/00 ,  H04N5/225

Abstract: A micro-plate reader for use with a portable electronic device having a camera includes an opto-mechanical attachment configured to attach/detach to the portable electronic device and includes an array of illumination sources. A slot in the opto-mechanical attachment is dimensioned to receive an optically transparent plate containing an array of wells. Optical fibers are located in the opto-mechanical attachment and transmit light from each well to a reduced size header having, wherein the fiber array in the header has a cross-sectional area that is ≤10× the cross-sectional area of the wells in the plate. A lens located in the opto-mechanical attachment transmits light from the header fibers to the camera. Software executed on the portable electronic device or other computer is used to process the images to generate qualitative clinical determinations and/or quantitative index values for the separate wells.

公开(公告)号：US20220268754A1

公开(公告)日：2022-08-25

申请号：US17627400

申请日：2020-07-29

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Kevin de Haan ,  Hatice Ceylan Koydemir ,  Sabiha Tok ,  Derek Tseng

IPC: G01N33/18 ,  G01N21/64 ,  G02B6/04 ,  F21V8/00 ,  G01N21/78

Abstract: A system for detecting the presence of E. coli and total coliform in a water sample includes a sample holder that holds smaller, divided volumes of the sample and a testing reagent. A plurality of light sources are disposed above sample holder. The divided sample volumes are are illuminated with first and second light sources emitting light at different wavelengths. A bundle of optical fibers is provided with having an input end located adjacent to the divided sample volumes and is configured to receive light passing through the sample volumes. Light is output from the bundle of optical fibers and is captured with a camera. Image processing software is provided and is configured to calculate a light intensity in first and second wavelength channels at different times and outputs a positive/negative indication for E. coli and total coliform for the water sample.

公开(公告)号：US11347000B2

公开(公告)日：2022-05-31

申请号：US15737743

申请日：2016-06-17

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Brandon Berg ,  Bingen Cortazar ,  Derek Tseng ,  Steve Wei Feng ,  Haydar Ozkan ,  Omai Garner ,  Dino Di Carlo

IPC: G02B6/06 ,  G06N20/00 ,  H04N5/225 ,  G01N21/25 ,  G01N33/53 ,  G01N35/00

Abstract: A micro-plate reader for use with a portable electronic device having a camera includes an opto-mechanical attachment configured to attach/detach to the portable electronic device and includes an array of illumination sources. A slot in the opto-mechanical attachment is dimensioned to receive an optically transparent plate containing an array of wells. Optical fibers are located in the opto-mechanical attachment and transmit light from each well to a reduced size header having, wherein the fiber array in the header has a cross-sectional area that is ≤10× the cross-sectional area of the wells in the plate. A lens located in the opto-mechanical attachment transmits light from the header fibers to the camera. Software executed on the portable electronic device or other computer is used to process the images to generate qualitative clinical determinations and/or quantitative index values for the separate wells.

公开(公告)号：US20180003686A1

公开(公告)日：2018-01-04

申请号：US15538309

申请日：2015-12-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Bingen Cortazar ,  Hatice Ceylan Koydemir ,  Derek Tseng ,  Steve Feng

IPC: G01N33/00 ,  G01N21/84 ,  G06K9/00 ,  G06K9/20 ,  G06K9/62 ,  G01N21/27 ,  G01N21/31 ,  G06K9/46 ,  G06K9/22 ,  G01N21/01

CPC classification number: G01N33/0098 ,  G01N21/274 ,  G01N21/31 ,  G01N21/84 ,  G01N2021/0125 ,  G01N2021/8466 ,  G01N2201/0221 ,  G01N2201/0627 ,  G01N2201/0634 ,  G06K9/00657 ,  G06K9/2027 ,  G06K9/2054 ,  G06K9/22 ,  G06K9/4661 ,  G06K9/6202 ,  G06T7/90 ,  H04Q9/00

Abstract: A system for measuring chlorophyll concentration in a leaf sample includes a leaf-holding illuminator device with a main body containing a power source, a plurality of switchable light sources emitting light at different spectra (e.g., red and white light from a broadband light source), and a cap detachably secured to the main body using one or more fastening means. The leaf sample is interposed between the main body and the cap and held in place during imaging. The system includes a mobile electronic device having a camera configured to capture an image of the leaf illuminated by the plurality of switchable light sources, the mobile electronic device having wireless connectivity to a network and an application contained therein configured to transfer the images to a remote sever or computer via the network for data processing. A final chlorophyll index value is calculated based on the transferred images.