公开(公告)号：US10139349B2

公开(公告)日：2018-11-27

申请号：US15645168

申请日：2017-07-10

Applicant: TODOS MEDICAL LTD.

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: G01N21/84 ,  A61B5/00 ,  G01N21/35 ,  G01J3/42

Abstract: A method is provided including obtaining an infrared (IR) spectrum of a blood plasma sample by analyzing the blood plasma sample by infrared spectroscopy, and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other applications are also described.

公开(公告)号：US11513112B2

公开(公告)日：2022-11-29

申请号：US16942714

申请日：2020-07-29

Applicant: TODOS MEDICAL LTD.

Inventor： Udi Zelig ,  Rami Zigdon

IPC: G01N33/48 ,  G01N33/483 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/35

Abstract: A method including identifying a subject as possibly having a benign tumor in ovarian tissue and obtaining an infrared spectrum of a PBMC sample of the subject and assessing a characteristic of the sample at at least one wavenumber selected from the group consisting of: 754.0±4 cm-1, 1103.6±4 cm-1, 1121.4±4 cm-1, 1346.1±4 cm-1, 1376.9±4 cm-1, 753.50±4 cm-1, 850.5±4 cm-1, 918.9±4 cm-1, 1058.7±4 cm-1, 1187.9±4 cm-1 and 1651.7±4 cm-1. Using a processor comparing, at the at least one wavenumber, the infrared spectrum to an infrared spectrum obtained from a PBMC sample from a person without a benign tumor, to detect a difference between the infrared spectrum of the PBMC sample of the subject and the infrared spectrum obtained from the PBMC sample from the person without a benign tumor. Other applications are also described.

公开(公告)号：US10732165B2

公开(公告)日：2020-08-04

申请号：US15785801

申请日：2017-10-17

Applicant: TODOS MEDICAL LTD.

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: G01N33/48 ,  G01N33/483 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/3563 ,  G01N21/35

Abstract: A method including identifying a subject as possibly having a benign tumor in ovarian tissue and obtaining an infrared spectrum of a PBMC sample of the subject and assessing a characteristic of the sample at at least one wavenumber selected from the group consisting of: 754.0±4 cm-1, 1103.6±4 cm-1, 1121.4±4 cm-1, 1346.1±4 cm-1, 1376.9±4 cm-1, 753.50±4 cm-1, 850.5±4 cm-1, 918.9±4 cm-1, 1058.7±4 cm-1, 1187.9±4 cm-1 and 1651.7±4 cm-1. Using a processor comparing, at the at least one wavenumber, the infrared spectrum to an infrared spectrum obtained from a PBMC sample from a person without a benign tumor, to detect a difference between the infrared spectrum of the PBMC sample of the subject and the infrared spectrum obtained from the PBMC sample from the person without a benign tumor. Other applications are also described.

公开(公告)号：US11561174B2

公开(公告)日：2023-01-24

申请号：US16789978

申请日：2020-02-13

Applicant: TODOS MEDICAL LTD.

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: G01J3/00 ,  G01N21/63 ,  G01J3/433 ,  G01N21/35 ,  G01N21/3563 ,  G01N15/14 ,  G01N15/00 ,  G01N15/10

Abstract: A system is provided comprising an FTIR spectrometer configured to obtain a Fourier Transformed infrared (FTIR) spectrum of a Peripheral Blood Mononuclear Cells (PBMC) sample of the subject; a data processor operable with the FTIR spectrometer, and configured to analyze the infrared (IR) spectrum of the Peripheral Blood Mononuclear Cells (PBMC) sample of the subject by assessing a characteristic of the sample of the subject at at least one wavenumber; and an output unit, configured to generate an output indicative of the presence of a solid tumor, based on the infrared (IR) spectrum. Other embodiments are also provided.

公开(公告)号：US10379056B2

公开(公告)日：2019-08-13

申请号：US16173838

申请日：2018-10-29

Applicant: TODOS MEDICAL LTD.

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: A61B5/00 ,  G01J3/42 ,  G01N21/35 ,  G01N21/84

Abstract: A method is provided including obtaining an infrared (IR) spectrum of a blood plasma sample by analyzing the blood plasma sample by infrared spectroscopy, and based on the infrared spectrum, generating an output indicative of the presence of a solid tumor or a pre-malignant condition. Other applications are also described.

公开(公告)号：US09804145B2

公开(公告)日：2017-10-31

申请号：US14894128

申请日：2013-11-14

Applicant: TODOS MEDICAL LTD.

Inventor： Joseph Kapelushnik ,  Shaul Mordechai ,  Ilana Nathan ,  Udi Zelig ,  Rami Zigdon

IPC: G01N33/48 ,  G01N33/483 ,  G01N21/3577 ,  G01N21/3563 ,  G01N21/359 ,  G01N21/35

CPC classification number: G01N33/4833 ,  G01N21/3563 ,  G01N21/3577 ,  G01N21/359 ,  G01N2021/3595 ,  G01N2201/12

Abstract: A method is provided comprising, obtaining an infrared (IR) spectrum of a Peripheral Blood Mononuclear Cells (PBMC) sample of a subject by analyzing the sample by infrared spectroscopy; analyzing the infrared spectrum using a processor (22), and based on the analyzing using the processor, using an output device (24), generating an output indicative of the presence of a benign tumor of the subject. Other applications are also described.