公开(公告)号：US10383917B2

公开(公告)日：2019-08-20

申请号：US15036518

申请日：2014-11-14

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Masanori Murayama

IPC: A61K38/19

Abstract: Provided is an agent for the treatment of an autoimmune disease, the agent comprising C1q/TNF-related protein 3 (CTRP3), and a method for the treatment of an autoimmune disease, the method comprising: administering an agent, which comprises CTRPb3 for the treatment of an autoimmune disease, to a subject in need of a treatment of an autoimmune disease.

公开(公告)号：US20160287669A1

公开(公告)日：2016-10-06

申请号：US15036518

申请日：2014-11-14

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Masanori Murayama

IPC: A61K38/19

CPC classification number: A61K38/191

Abstract: Provided is an agent for the treatment of an autoimmune disease, the agent comprising CTRP3, and a method for the treatment of an autoimmune disease, the method comprising: administering an agent, which comprises CTRP3 for the treatment of an autoimmune disease, to a subject in need of a treatment of an autoimmune disease.

Abstract translation: 本发明提供一种治疗自身免疫性疾病的药剂，包含CTRP3的药剂和治疗自身免疫性疾病的方法，该方法包括：向患者施用包含CTRP3的用于治疗自身免疫性疾病的药剂 需要治疗自身免疫性疾病。

公开(公告)号：US11324809B2

公开(公告)日：2022-05-10

申请号：US16611883

申请日：2018-05-14

Applicant: Tokyo University of Science Foundation

Inventor： Yoichiro Iwakura ,  Tomonori Kaifu

IPC: A61K38/47 ,  A61P37/06 ,  A61P19/02

Abstract: Provided are: a pharmaceutical composition for curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor, in which the pharmaceutical composition contains a carbohydrate modifying enzyme as an active ingredient; and a method of curing, treating, or preventing a disease involving a biological mechanism controlled by a dendritic cell immunoreceptor.

公开(公告)号：US10792300B2

公开(公告)日：2020-10-06

申请号：US15323748

申请日：2015-07-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Tomonori Kaifu ,  Rikio Yabe

IPC: A61K31/715 ,  C12N5/0784 ,  G01N33/50

Abstract: A dendritic cell immune receptor activator, comprising a compound having a sugar chain as an active ingredient, the sugar chain having a basic structure represented by the following formula: wherein, in the formula, a sialic acid does not exist at two non-reducing terminals, and each of x and y independently represents 3 or 4.

公开(公告)号：US20170143754A1

公开(公告)日：2017-05-25

申请号：US15323748

申请日：2015-07-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Tomonori Kaifu ,  Rikio Yabe

IPC: A61K31/715 ,  G01N33/50 ,  C12N5/0784

Abstract: A dendritic cell immune receptor activator, comprising a compound having a sugar chain as an active ingredient, the sugar chain having a basic structure represented by the following formula: wherein, in the formula, a sialic acid does not exist at two non-reducing terminals, and each of x and y independently represents 3 or 4.

公开(公告)号：US20250057873A1

公开(公告)日：2025-02-20

申请号：US18719731

申请日：2022-10-12

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang

IPC: A61K31/716 ,  A61P35/00 ,  C07K16/28

Abstract: An intestinal tumor suppressor that contains a Dectin-1 inhibitor or a β-glucan having a Dectin-1 inhibitory activity and that suppresses an intestinal tumor through Dectin-1 inhibition; a PGE2 production inhibitor that contains a β-glucan having a Dectin-1 inhibitory activity; and an IL-22BP production promoter containing a β-glucan having a Dectin-1 inhibitory activity, are provided.

公开(公告)号：US20160002364A1

公开(公告)日：2016-01-07

申请号：US14772839

申请日：2014-03-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang ,  Naohito Ohno

IPC: C08B37/00 ,  C12Q1/02 ,  G01N33/50 ,  C12N1/20

CPC classification number: C08B37/0024 ,  C12N1/20 ,  C12Q1/025 ,  G01N33/505 ,  G01N2333/335

Abstract: A growth enhancer for Lactobacillus murinus, Lactobacillus salivarius, or a bacterium that belongs to the genus Lactobacillus and that has a homology of 16S rDNA of 90% or higher with Lactobacillus murinus or Lactobacillus salivarius includes a β-glucan having a molecular weight of from 0.2 K to 50 K. A regulatory T-cell number increasing agent, a method of enhancing growth of a lactic acid bacterium, a method of increasing the number of regulatory T-cells, a method of evaluating a regulatory T-cell number increasing effect, and a method of evaluating a growth enhancing effect on a lactic acid bacterium are also provided.

Abstract translation: 具有Lactobacillus murinus或Lactobacillus salivarius的Lactobacillus murinus，唾液乳杆菌或属于乳杆菌属的细菌并且具有90％或更高的同源性的细菌的生长增强剂包括分子量为 0.2K〜50K。调节性T细胞数增加剂，增强乳酸菌生长的方法，增加调节性T细胞数量的方法，评价调节性T细胞数增加效果的方法 ，还提供了对生乳增殖效果进行评价的乳酸菌的评价方法。

公开(公告)号：US09738731B2

公开(公告)日：2017-08-22

申请号：US14772839

申请日：2014-03-10

Applicant: TOKYO UNIVERSITY OF SCIENCE FOUNDATION

Inventor： Yoichiro Iwakura ,  Ce Tang ,  Naohito Ohno

IPC: A61K31/00 ,  C08B37/00 ,  C12N1/20 ,  C12Q1/02 ,  G01N33/50

CPC classification number: C08B37/0024 ,  C12N1/20 ,  C12Q1/025 ,  G01N33/505 ,  G01N2333/335

Abstract: A growth enhancer for Lactobacillus murinus, Lactobacillus salivarius, or a bacterium that belongs to the genus Lactobacillus and that has a homology of 16S rDNA of 90% or higher with Lactobacillus murinus or Lactobacillus salivarius includes a β-glucan having a molecular weight of from 0.2 K to 50 K. A regulatory T-cell number increasing agent, a method of enhancing growth of a lactic acid bacterium, a method of increasing the number of regulatory T-cells, a method of evaluating a regulatory T-cell number increasing effect, and a method of evaluating a growth enhancing effect on a lactic acid bacterium are also provided.