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公开(公告)号：US11142731B2
公开(公告)日：2021-10-12
申请号：US15854355
申请日：2017-12-26
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Tomoko Kunitomi , Yoichi Makino
Abstract: An analytical device includes a plate including a first substrate having a front surface and a back surface and a second substrate facing the back surface of the first substrate such that at least one detection space observable from outside is formed between the second substrate and the back surface of the first substrate, and an adapter. The first substrate has a first port having a through hole formed through the front surface and communicated with the detection space for delivering a liquid-containing substance into the detection space, the first substrate has a second port having a through hole formed through the front surface and communicated with the detection space for discharging a liquid-containing substance or a gas from the detection space, and the adapter is attachable to and detachable from the first port and the second port, and the front surface of the first substrate without the adapter is flat.
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公开(公告)号：US10894973B2
公开(公告)日：2021-01-19
申请号：US15586622
申请日：2017-05-04
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi Makino , Tomoyuki Ozawa , Shuichi Akashi , Tomoko Kunitomi
Abstract: An array device including a base having wells, a cover positioned over the base with a gap from the base such that openings of the wells are covered by the cover with the gap in between, an injection port communicating with the gap, a discharge port communicating with the gap and positioned apart from the injection port, and a waste liquid vessel which collects liquid that flows from the gap via the discharge port and is positioned at a level different from the gap forming a channel. The discharge port is placed to discharge a surplus aqueous solution outside the wells from the discharge port by an oleaginous sealing liquid to be delivered from the injection port.
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公开(公告)号：US11739288B2
公开(公告)日：2023-08-29
申请号：US17481354
申请日：2021-09-22
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Tomoko Kunitomi , Yoichi Makino
CPC classification number: C12M1/34 , B01L3/50851 , C12M1/00 , C12Q1/6825 , G01N21/64 , G01N21/6452 , B01L3/563 , B01L7/52 , B01L2200/026 , B01L2300/069 , B01L2300/0654 , B01L2300/0819
Abstract: A method for filling an analytical device includes providing a plate having a detection space or spaces and ports communicating with the space(s), fitting, into one of the ports, an adapter having a reagent fixed on an inner wall of the adapter such that a first end of the adapter is fitted into the port, and delivering a sample solution into the detection space(s) through the adapter such that the sample solution and reagent fill the detection space(s). The plate includes a first substrate, a second substrate, and a side wall such that the plate has the detection space(s) between the substrates and that the first substrate has the ports, the first and/or second substrates is formed of transparent material such that the detection space is observable from outside the plate, and the ports include a first port for delivering liquid-containing substance, and a second port for discharging the substance.
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Patent Agency Ranking
公开(公告)号：US11261484B2
公开(公告)日：2022-03-01
申请号：US15221143
申请日：2016-07-27
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi Makino , Tomoko Kunitomi
IPC: B01L3/00 , C12Q1/6858 , G01N21/64 , C12Q1/686
Abstract: A biomolecule analysis kit includes a reaction container configured to perform an enzymatic reaction, the reaction container including a base portion which has a container-shaped portion and a low-adsorption structural portion which is provided on at least the inner surface of the container-shaped portion, the low-adsorption structural portion having an adsorption rate lower than the base portion at which at least one of a sample which becomes a target of analysis in the enzymatic reaction and a reagent for the enzymatic reaction is adsorbed thereonto, wherein a signal resulting from the enzymatic reaction is configured to be detected when the enzymatic reaction is performed in the reaction container.
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公开(公告)号：US20190241948A1
公开(公告)日：2019-08-08
申请号：US16387241
申请日：2019-04-17
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi Makino , Tomoko Kunitomi
IPC: C12Q1/6858 , C12Q1/686 , G01N21/64 , B01L3/00
CPC classification number: C12Q1/6858 , B01L3/502715 , B01L3/502746 , B01L2200/0642 , B01L2200/0673 , B01L2200/0689 , B01L2300/0829 , B01L2300/0851 , B01L2300/0864 , B01L2300/0887 , B01L2300/123 , B01L2300/161 , B01L2300/168 , B01L2400/0487 , B01L2400/086 , C12Q1/686 , G01N21/6428 , G01N21/6452 , G01N2021/6439
Abstract: A biomolecule analysis method including: feeding a reagent into a reaction container which includes a plurality of wells and filing the reagent in the plurality of wells, the reagent being for causing an enzymatic reaction with regard to a target substance of analysis; feeding an oil sealing solution over the plurality of wells and sealing the reagent into the plurality of wells with the oil sealing solution so that the plurality of wells become a plurality of independent reaction containers; performing the enzymatic reaction by incubating the reaction container; and detecting a signal amplified by the enzymatic reaction.
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公开(公告)号：US11559804B2
公开(公告)日：2023-01-24
申请号：US16173102
申请日：2018-10-29
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi Makino , Akihiro Hoshino , Tomoko Kunitomi , Keisuke Goto , Yosuke Horiuchi
Abstract: An analysis apparatus including a stage, an analysis device placed on the stage and including receiving sections which accommodate a sample and a reagent for biochemical reaction, and are communicated with one another through a flow path having an inlet and an outlet, a liquid introduction section which is connected to the inlet and supplies into the flow path the sample, the reagent, and an sealing liquid for sealing each of the receiving sections, and a waste liquid storage section which is connected to the outlet and stores as waste liquid an excess of the sample and the reagent and a part of the sealing liquid supplied to the flow path, an optical system which includes an objective lens, emits excitation light to the receiving sections and allows observation of fluorescence generated in the receiving sections by the excitation light, and a control unit that controls such that the sealing liquid and the excess of the sample and the reagent form an interface in the waste liquid storage section, and that the interface is formed at a distance not less than a fluorescence-obtainable distance from a bottom of the receiving sections.
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公开(公告)号：US11371089B2
公开(公告)日：2022-06-28
申请号：US16387241
申请日：2019-04-17
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi Makino , Tomoko Kunitomi
IPC: B01L3/00 , C12Q1/6858 , G01N21/64 , C12Q1/686
Abstract: A biomolecule analysis method including: feeding a reagent into a reaction container which includes a plurality of wells and filing the reagent in the plurality of wells, the reagent being for causing an enzymatic reaction with regard to a target substance of analysis; feeding an oil sealing solution over the plurality of wells and sealing the reagent into the plurality of wells with the oil sealing solution so that the plurality of wells become a plurality of independent reaction containers; performing the enzymatic reaction by incubating the reaction container; and detecting a signal amplified by the enzymatic reaction.
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公开(公告)号：US20160333400A1
公开(公告)日：2016-11-17
申请号：US15221143
申请日：2016-07-27
Applicant: TOPPAN PRINTING CO., LTD.
Inventor： Yoichi MAKINO , Tomoko Kunitomi
Abstract: A biomolecule analysis kit includes a reaction container configured to perform an enzymatic reaction, the reaction container including a base portion which has a container-shaped portion and a low-adsorption structural portion which is provided on at least the inner surface of the container-shaped portion, the low-adsorption structural portion having an adsorption rate lower than the base portion at which at least one of a sample which becomes a target of analysis in the enzymatic reaction and a reagent for the enzymatic reaction is adsorbed thereonto, wherein a signal resulting from the enzymatic reaction is configured to be detected when the enzymatic reaction is performed in the reaction container.
Abstract translation: 生物分子分析试剂盒包括配置成进行酶反应的反应容器，反应容器包括具有容器形状部分和至少设置在容器形状部分的内表面上的低吸附结构部分的基部 低吸附结构部分的吸附率低于在酶反应中成为分析对象的样品中的至少一种和酶反应试剂中的至少一种的吸附速率，其中产生的信号 在反应容器中进行酶反应时，酶反应被配置为检测。
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