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公开(公告)号：US11318199B2
公开(公告)日：2022-05-03
申请号：US16616171
申请日：2018-05-31
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Akhilesh Kumar Shakya
Abstract: Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin.
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公开(公告)号：US20210315990A1
公开(公告)日：2021-10-14
申请号：US17354099
申请日：2021-06-22
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Akhilesh Kumar Shakya
Abstract: Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin.
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公开(公告)号：US20230285542A1
公开(公告)日：2023-09-14
申请号：US18006097
申请日：2021-07-22
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Gaurav Joshi
IPC: A61K39/215 , A61K39/39 , A61K39/155 , A61K39/145 , A61K39/235 , A61K39/125 , A61K39/12 , A61P31/14
CPC classification number: A61K39/215 , A61K39/39 , A61K39/155 , A61K39/145 , A61K39/235 , A61K39/125 , A61K39/12 , A61P31/14 , A61K2039/55572
Abstract: The present invention includes and immunogenic composition and methods of immunizing a mammal or avian comprising: a nanoparticle conjugated to one or more antigenic peptides or fusion polypeptides from more than one strain of virus, wherein the one or more antigenic peptides or fusion polypeptides elicit at least one of a humoral, T helper cell-1 (Th1), T helper cell-2 (Th2) or cytotoxic T cell (CTL) immune response. In certain embodiments the antigenic peptides or fusion polypeptides are selected from at least one of SEQ IN NOS: 1 to 16, 22 to 39, or any combination thereof.
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公开(公告)号：US11623076B2
公开(公告)日：2023-04-11
申请号：US17050961
申请日：2019-05-01
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Seth Boese
Abstract: The present invention includes a medicated dental floss and a method of making a medicated dental floss comprising: stretching a dental floss; dipping the dental floss in a biocompatible polymer—solvent bath to coat the braided dental floss; drying the coated braided dental floss; dipping the coated dental floss in a medicated solution comprising an encapsulated medicament; and drying the medicated encapsulant on the coated dental floss.
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公开(公告)号：US20230042036A1
公开(公告)日：2023-02-09
申请号：US17956270
申请日：2022-09-29
Applicant: Texas Tech University System , 3i Biotechnologies LLC
Inventor： David Syn , Harvinder Singh Gill , Seth Bose , Rohan J. Ingrole
Abstract: The present invention includes composition and methods of delivering one or more nutrients to a subject comprising: delivering an effective amount of one or more nutrients into a gingival crevice wherein the amount is sufficient to supplement the diet of the subject for the nutrients.
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Patent Agency Ranking
公开(公告)号：US11510979B2
公开(公告)日：2022-11-29
申请号：US16753612
申请日：2018-10-02
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Akhilesh Shakya
Abstract: The present invention includes composition and methods for composition for the oral delivery of a therapeutic agent that reduces, desensitizes, or prevents food, respiratory and other allergies. First pollen is cleaned to remove naturally-occurring allergic plant proteins to form a cleaned pollen and a therapeutically effective amount of an allergen is introduced into the cleaned pollen. The allergen-loaded cleaned pollen is delivered to a subject in need of therapy.
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公开(公告)号：US20210230552A1
公开(公告)日：2021-07-29
申请号：US17231495
申请日：2021-04-15
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Chang Hyun Lee
IPC: C12N5/077 , C12N5/00 , C07K7/06 , C07K14/52 , C07K14/475
Abstract: The present invention includes a polypeptide for use in a three dimensional (3D) culture system for the growth of cells comprising one or more repeats of a sequence n1-(X1X2GXP)-n2 (SEQ ID NO:8), wherein X1 and X2 are any amino acids except proline, wherein X1 and X2 can be the same or different amino acid in solution or coated on a substrate, wherein n1 and n2 are equal to or greater than one, and wherein X is an aliphatic amino acid.
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公开(公告)号：US20180092852A1
公开(公告)日：2018-04-05
申请号：US15725099
申请日：2017-10-04
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Shashwati U. Atwe , Pedro E. Gonzalez-Cruz
CPC classification number: A61K9/4816 , A61K9/1664 , A61K9/4858 , A61K9/5063 , A61K9/5068 , A61K36/00 , A61K38/00 , A61K39/00
Abstract: The present invention includes methods of making a hollow exine shell from pollen grains comprising the steps of: providing a plant pollen or spore; extracting organic matter from the plant pollen or spore with an organic solvent; after the organic extraction treating the plant pollen or spore with an acid solution; after the acid treatment treating the plant pollen or spore with an alkali solution; and isolating the plant pollen or spore, wherein the pollen or spore have open apertures on pollens with visible apertures that open to the interior hollow cavity, wherein the same apertures are closed in naturally occurring pollens.
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公开(公告)号：US20230346529A9
公开(公告)日：2023-11-02
申请号：US17956270
申请日：2022-09-29
Applicant: Texas Tech University System , 3i Biotechnologies LLC
Inventor： David Syn , Harvinder Singh Gill , Seth Bose , Rohan J. Ingrole
CPC classification number: A61C15/041 , A23L33/15 , A23L33/16
Abstract: The present invention includes composition and methods of delivering one or more nutrients to a subject comprising: delivering an effective amount of one or more nutrients into a gingival crevice wherein the amount is sufficient to supplement the diet of the subject for the nutrients.
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公开(公告)号：US20220211842A1
公开(公告)日：2022-07-07
申请号：US17697467
申请日：2022-03-17
Applicant: Texas Tech University System
Inventor： Harvinder Singh Gill , Akhilesh Kumar Shakya
Abstract: Methods and devices are provided for treating a food allergy in a subject in need thereof. The method entails delivering an effective amount of an allergen associated with the food allergy into the subject's cutis skin layer. Delivering the allergen is carried out by inserting one or more allergen-coated solid microneedles into the subject's skin. The one or more solid microneedles each has a base, shaft and tip, and when inserted in the subject, do not extend beyond the cutis. The allergen is allowed to dissociate from the one or more microneedles while inserted in the subject's cutis. Once the allergen disassociates, the one or more microneedles is removed from the subject's skin.
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