公开(公告)号：US20210403416A1

公开(公告)日：2021-12-30

申请号：US17251469

申请日：2019-06-13

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Ted W. Reid ,  Mayank Shashtri ,  Peter Syapin ,  Phat Tran

IPC: C07C237/26 ,  C07D317/72 ,  A61B5/00

Abstract: The present invention includes novel molecules and methods for using the same to treat Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: identifying a subject in need of treatment for at least one of AUD, SUD, pain, or a proinflammatory disorder; and providing the subject with an effective amount of a modified minocycline to ameliorate or eliminate the AUD, SUD, pain, or proinflammatory disorder and that has reduced, or no, antimicrobial activity, wherein the modified tetracycline has a formula, e.g., or the modified doxycycline, minocycline, and tigecycline and their tautomerized structures, where the R-groups shown in the minocycline example above could be different combination of halogen, acetyl ester, methyl ester, and diacetal.

公开(公告)号：US12202785B2

公开(公告)日：2025-01-21

申请号：US18059533

申请日：2022-11-29

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shastri ,  Phat Tran

IPC: C07C237/26 ,  A61B5/00 ,  A61K31/65 ,  C07D317/72

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

公开(公告)号：US11542227B2

公开(公告)日：2023-01-03

申请号：US16973896

申请日：2019-06-13

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shashtri ,  Phat Tran

IPC: A61K31/65 ,  C07C237/26 ,  A61B5/00 ,  C07D317/72

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

公开(公告)号：US20250129014A1

公开(公告)日：2025-04-24

申请号：US18975409

申请日：2024-12-10

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shashtri ,  Phat Tran

IPC: C07C237/26 ,  A61B5/00 ,  A61K31/65 ,  C07D317/72

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.

公开(公告)号：US20230127462A1

公开(公告)日：2023-04-27

申请号：US18059533

申请日：2022-11-29

Applicant: Texas Tech University System

Inventor： Susan E. Bergeson ,  Peter Syapin ,  Ted W. Reid ,  Mayank Shastri ,  Phat Tran

IPC: C07C237/26 ,  A61B5/00 ,  C07D317/72 ,  A61K31/65

Abstract: A method of treating Alcohol Use Disorder (AUD), Substance Use Disorder (SUD), tobacco use, pain, or proinflammatory disorders comprising: providing a subject with an effective amount of a modified tetracycline or derivative thereof to ameliorate or eliminate the AUD, SUD, tobacco use, pain, or proinflammatory disorder, and wherein the modified tetracycline or derivative thereof has reduced binding to a microbial ribosome and has the formula: wherein R1 is acetyl, R2 is OH or acetyl, R3 is acetyl, R4 is H or acetyl, and R5 is acetyl.