公开(公告)号：US11547725B2

公开(公告)日：2023-01-10

申请号：US16478969

申请日：2017-12-21

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Pamela S. Ohashi ,  Michael St. Paul ,  Sam Saibil

IPC: A61K35/17 ,  C12N5/0783 ,  C07K16/22 ,  C07K16/24 ,  C07K16/28

Abstract: There is described herein, a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population; and c) culturing or contacting the population of CD8+ T cells with Coenzyme A.

公开(公告)号：US11191782B2

公开(公告)日：2021-12-07

申请号：US16478787

申请日：2017-12-19

Applicant: UNIVERSITY HEALTH NETWORK

Inventor： Pamela S. Ohashi ,  Michael St. Paul

IPC: A61K35/17 ,  A61K38/20 ,  A61P35/00 ,  C07K14/525 ,  C07K14/54 ,  C07K14/705 ,  C07K16/24 ,  C07K16/28

Abstract: There is described herein a method for inducing Tc22 lineage T cells from a population of CD8+ T cells, the method comprising: a) providing a population of CD8+ T cells; b) activating the population of CD8+ T cells; and c) culturing or contacting the population of CD8+ T cells with IL-6.