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    METHOD, DEVICE AND SYSTEM FOR SIMULATING AND/OR DELIVERING DEEP BRAIN STIMULATION
    1.
    发明申请
    METHOD, DEVICE AND SYSTEM FOR SIMULATING AND/OR DELIVERING DEEP BRAIN STIMULATION 有权

    公开(公告)号：US20220152396A1

    公开(公告)日：2022-05-19

    申请号：US17527042

    申请日：2021-11-15

    Applicant: University Health Network

    Inventor： Luka Milosevic ,  Milos R. Popovic ,  Milad Lankarany ,  William D. Hutchison

    IPC: A61N1/36 ,  A61N1/05

    Abstract: Various embodiments are described herein for a device, system and method for delivering deep brain stimulation of a target structure. A target model corresponding to the target structure is used where the model includes a neuronal model for modeling one or more neurons of the target structure and a short-term plasticity model for modeling temporal behaviour of the neuron in response to one or more stimulus pulses over time. The method generally includes receiving input data related to the target structure including a brain region of the target structure, stimulus parameters including pulse frequency, and model parameters that correspond to the brain structure; determining a neuronal response of the target structure by applying the stimulus parameters and the model parameters to the target model; and performing any combination of outputting the neuronal response, storing the neuronal response and transmitting the neuronal response to another device.

    Functional electrical stimulation device and system, and use thereof
    2.
    发明授权
    Functional electrical stimulation device and system, and use thereof 有权
    功能性电刺激装置及系统及其用途

    公开(公告)号：US09440077B2

    公开(公告)日：2016-09-13

    申请号：US14500749

    申请日：2014-09-29

    Applicant: University Health Network

    Inventor： Milos R. Popovic ,  Massimo Tarulli ,  Aleksandar Prodic ,  Peter Lehn

    IPC: A61N1/36 ,  H03K3/78 ,  A61N1/04

    CPC classification number: A61N1/36125 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36171 ,  H03K3/78

    Abstract: A functional electrical stimulation (FES) device and system. In one embodiment, sequential bipolar pulse stimulation may be provided to an area of a living body via one or more electrode leads applied to the area via a FES device comprising a current pulse generating circuit comprising output nodes for operative coupling to the one or more electrode leads, and configured for operative coupling to a voltage supply. The current pulse generating circuit generally comprises positive and negative stimulation paths drawing from the voltage supply to respectively apply positive and negative currents through the area via the one or more electrode leads. In one example, the stimulation paths comprise respective capacitive elements, a capacitance ratio of which dictating, at least in part, an amplitude ratio of the positive and negative currents, wherein periodic alternative activation of the stimulation paths provides the sequential bipolar pulse stimulation.

    Abstract translation: 功能性电刺激（FES）装置和系统。 在一个实施例中，顺序双极脉冲刺激可以经由经由FES装置施加到该区域的一个或多个电极引线提供给生物体的一个区域，该FES装置包括电流脉冲发生电路，该电流脉冲发生电路包括用于与一个或多个电极 引线，并被配置为与电压源的操作耦合。 电流脉冲发生电路通常包括从电压源抽取的正和负刺激路径，以分别通过一个或多个电极引线通过该区域施加正电流和负电流。 在一个示例中，刺激路径包括相应的电容元件，其电容比至少部分地表示正和负电流的振幅比，其中刺激路径的周期性替代激活提供顺序的双极脉冲刺激。

    Functional electrical stimulation method, use and apparatus for mood alteration
    6.
    发明授权
    Functional electrical stimulation method, use and apparatus for mood alteration 有权
    功能电刺激方法，心情改变的使用和装置

    公开(公告)号：US09259576B2

    公开(公告)日：2016-02-16

    申请号：US14204829

    申请日：2014-03-11

    Applicant: UNIVERSITY HEALTH NETWORK

    Inventor： Milos R. Popovic ,  Jose Zariffa ,  Sander L. Hitzig

    IPC: A61N1/00 ,  A61N1/36 ,  A61N1/05 ,  A61N1/04

    CPC classification number: A61N1/36096 ,  A61N1/0452 ,  A61N1/0504

    Abstract: A method and apparatus for providing functional electrical stimulation to an individual for altering a mood or emotional parameter associated with a mood or emotional state is provided. The method involves providing functional electrical stimulation to facial muscles of the individual so as to elicit a detectable contraction in said muscles associated with a facial expression associated with a desired mood or emotional parameter.

    Abstract translation: 提供了一种用于向个人提供功能性电刺激以改变与情绪或情绪状态相关联的情绪或情绪参数的方法和装置。 该方法涉及对个体的面部肌肉提供功能性电刺激，从而在与期望的情绪或情绪参数相关联的面部表情相关联的所述肌肉中引发可检测的收缩。

    Functional Electrical Stimulation Device and System, and Use Thereof
    7.
    发明申请
    Functional Electrical Stimulation Device and System, and Use Thereof 有权
    功能电刺激装置和系统及其应用

    公开(公告)号：US20150039051A1

    公开(公告)日：2015-02-05

    申请号：US14500749

    申请日：2014-09-29

    Applicant: University Health Network

    Inventor： Milos R. Popovic ,  Massimo Tarulli ,  Aleksandar Prodic ,  Peter Lehn

    IPC: A61N1/36

    CPC classification number: A61N1/36125 ,  A61N1/0476 ,  A61N1/36003 ,  A61N1/36014 ,  A61N1/36067 ,  A61N1/36103 ,  A61N1/3615 ,  A61N1/36167 ,  A61N1/36171 ,  H03K3/78

    Abstract: A functional electrical stimulation (FES) device and system. In one embodiment, sequential bipolar pulse stimulation may be provided to an area of a living body via one or more electrode leads applied to the area via a FES device comprising a current pulse generating circuit comprising output nodes for operative coupling to the one or more electrode leads, and configured for operative coupling to a voltage supply. The current pulse generating circuit generally comprises positive and negative stimulation paths drawing from the voltage supply to respectively apply positive and negative currents through the area via the one or more electrode leads. In one example, the stimulation paths comprise respective capacitive elements, a capacitance ratio of which dictating, at least in part, an amplitude ratio of the positive and negative currents, wherein periodic alternative activation of the stimulation paths provides the sequential bipolar pulse stimulation.

    Abstract translation: 功能性电刺激（FES）装置和系统。 在一个实施例中，顺序双极脉冲刺激可以经由经由FES装置施加到该区域的一个或多个电极引线提供给生物体的一个区域，该FES装置包括电流脉冲发生电路，该电流脉冲发生电路包括用于与一个或多个电极 引线，并被配置为与电压源的操作耦合。 电流脉冲发生电路通常包括从电压源抽取的正和负刺激路径，以分别通过一个或多个电极引线通过该区域施加正电流和负电流。 在一个示例中，刺激路径包括相应的电容元件，其电容比至少部分地表示正和负电流的振幅比，其中刺激路径的周期性替代激活提供顺序的双极脉冲刺激。

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