公开(公告)号：US09664680B2

公开(公告)日：2017-05-30

申请号：US15059797

申请日：2016-03-03

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/49 ,  G01N33/574 ,  G01N21/552 ,  G01N33/00 ,  G01N33/566 ,  C40B30/04 ,  G01N21/35 ,  G01J3/433 ,  G01N21/63 ,  G01N30/74 ,  G01N21/31

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

公开(公告)号：US10288615B2

公开(公告)日：2019-05-14

申请号：US15491305

申请日：2017-04-19

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/574 ,  G01N21/552 ,  G01N21/63 ,  G01N21/35 ,  G01N33/49 ,  G01J3/433 ,  G01N30/74 ,  G01N21/31

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumors merely by assaying or analyzing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumors in a subject.

公开(公告)号：US20150301017A1

公开(公告)日：2015-10-22

申请号：US14443134

申请日：2013-11-14

Applicant: UNIVERSITY OF CENTRAL LANCASHIRE

Inventor： Matthew James Baker ,  Peter Abel ,  Robert William Lea

IPC: G01N33/49

CPC classification number: G01N33/57407 ,  G01J3/433 ,  G01N21/35 ,  G01N21/552 ,  G01N21/63 ,  G01N33/49 ,  G01N33/574 ,  G01N2021/3196 ,  G01N2021/3595 ,  G01N2030/743 ,  G01N2201/129 ,  G01N2800/52 ,  G01N2800/7028

Abstract: The present invention relates to methods of diagnosing and/or prognosing proliferative disorders, especially brain cancers (e.g. gliomas). In particular, the present invention provides a means to conveniently detect malignant tumours merely by assaying or analysing blood (particularly blood serum). Cytokines and/or angiogenesis factors in blood serum have been found to be surprisingly powerful at indicating the presence of brain cancers in a subject. Moreover, spectroscopic analysis, especially ATR-FTIR analysis, of a blood sample has been demonstrated to be surprisingly effective at producing a signature that can be correlated with the presence, extent, severity, or aggressiveness of malignant tumours in a subject.

Abstract translation: 本发明涉及诊断和/或预测增殖性疾病，特别是脑癌（例如神经胶质瘤）的方法。 特别地，本发明提供了仅通过测定或分析血液（特别是血清）便利地检测恶性肿瘤的手段。 已经发现血清中的细胞因子和/或血管生成因子在表明受试者中脑癌的存在方面令人惊讶地强大。 此外，血液样品的光谱分析，特别是ATR-FTIR分析已经被证明在产生可以与受试者中恶性肿瘤的存在，程度，严重性或侵袭性相关的特征方面令人惊奇地有效。