公开(公告)号：US12097050B2

公开(公告)日：2024-09-24

申请号：US17434333

申请日：2020-02-27

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Stephen Baek ,  Yusen He ,  Xiaodong Wu ,  Yusung Kim ,  Bryan G. Allen ,  John Buatti ,  Brian J. Smith

IPC: A61B5/00 ,  G06T7/11

CPC classification number: A61B5/7264 ,  A61B5/7275 ,  G06T7/11 ,  G06T2200/04 ,  G06T2207/10081 ,  G06T2207/10104 ,  G06T2207/20084 ,  G06T2207/30096

Abstract: Methods and systems for image segmentation and analysis are described. A predictive model may be trained to identify and/or extract a rich set of image features with extensive prognostic value. For example, the predictive model may be trained to identify and/or extract features that that may be visualized to identify areas of interest (e.g., high-risk regions, etc.) within or adjacent to an object of interest, such a tumor. The predictive model may be trained to identify and/or extract features that that may predict a health related outcome, such as cancer patient survival/death, and modify therapeutic outcomes, such as diagnosis and treatment.

公开(公告)号：US10052304B2

公开(公告)日：2018-08-21

申请号：US15291833

申请日：2016-10-12

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Bryan G. Allen ,  Douglas R. Spitz ,  Garry R. Buettner ,  Joseph Cullen ,  Joshua Schoenfeld ,  Michael Schultz ,  Fenghuang Zhan

IPC: A61N5/10 ,  A61K31/282 ,  A61K31/337 ,  A61K31/375 ,  A61K31/7068 ,  A61K45/06 ,  A61K9/00 ,  A61K31/295 ,  A61K31/704 ,  A61K31/198 ,  A61K31/555 ,  A61K47/22

CPC classification number: A61K31/375 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/282 ,  A61K31/295 ,  A61K31/337 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.

公开(公告)号：US20180200540A1

公开(公告)日：2018-07-19

申请号：US15408824

申请日：2017-01-18

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Ryan Flynn ,  Junyi Xia ,  Timothy J. Waldron ,  Yusung Kim ,  Bryan G. Allen ,  Brennen M. Wears ,  Hongtao Ding

IPC: A61N5/10

CPC classification number: A61N5/1001 ,  A61N5/1045 ,  A61N5/1083

Abstract: Systems and methods for low energy radiation x-ray radiation therapy system for use at a target within a cavity of a subject. In an aspect, the system uses an aperture shaping device used to shape the radiation beam from the low energy radiation source. In an aspect, the aperture shaping device includes a plurality of leaf assemblies which include leaves configured to form the aperture and engage the radiation beam. In an aspect, the present invention utilizes a geared mechanics approach to create an aperture using only one dial input. The design ensures that the field size of the collimator remains a constant shape as it is opened and closed. In an aspect, the overall size of the collimator may be scaled to accommodate various radiation therapy requirements.

公开(公告)号：US20170100370A1

公开(公告)日：2017-04-13

申请号：US15291833

申请日：2016-10-12

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Bryan G. Allen ,  Douglas R. Spitz ,  Garry R. Buettner ,  Joseph Cullen ,  Joshua Schoenfeld ,  Michael Schultz ,  Fenghuang Zhan

IPC: A61K31/375 ,  A61K31/337 ,  A61K31/282 ,  A61N5/10 ,  A61K31/704 ,  A61K31/7068 ,  A61K31/295 ,  A61K45/06 ,  A61K9/00

CPC classification number: A61K31/375 ,  A61K9/0019 ,  A61K31/198 ,  A61K31/282 ,  A61K31/295 ,  A61K31/337 ,  A61K31/555 ,  A61K31/704 ,  A61K31/7068 ,  A61K45/06 ,  A61K47/22 ,  A61N2005/1098 ,  A61K2300/00

Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.