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公开(公告)号：US10052304B2
公开(公告)日：2018-08-21
申请号：US15291833
申请日：2016-10-12
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Bryan G. Allen , Douglas R. Spitz , Garry R. Buettner , Joseph Cullen , Joshua Schoenfeld , Michael Schultz , Fenghuang Zhan
IPC: A61N5/10 , A61K31/282 , A61K31/337 , A61K31/375 , A61K31/7068 , A61K45/06 , A61K9/00 , A61K31/295 , A61K31/704 , A61K31/198 , A61K31/555 , A61K47/22
CPC classification number: A61K31/375 , A61K9/0019 , A61K31/198 , A61K31/282 , A61K31/295 , A61K31/337 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/22 , A61N2005/1098 , A61K2300/00
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.
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公开(公告)号：US20220031674A1
公开(公告)日：2022-02-03
申请号：US16945323
申请日：2020-07-31
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz
IPC: A61K31/437 , A61K31/198 , A61K31/4706 , A61K31/66 , C07K16/28 , A61P35/04
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
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公开(公告)号：US11529335B2
公开(公告)日：2022-12-20
申请号：US16945323
申请日：2020-07-31
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz
IPC: A61K31/437 , A61P35/04 , A61K31/198 , A61K31/4706 , A61K31/66 , C07K16/28
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
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4.发明申请MITOCHONDRIAL-TARGETED CATIONIC NANOPARTICLES COMPRISING CAMKII INHIBITORS AND USES THEREOF FOR TREATING AND PREVENTING DISEASES AND DISORDERS ASSOCIATED WITH CAMKII ACTIVITY 有权包含CAMKII抑制剂的MITOCHONDRIAL-TARCTENT阳离子纳米颗粒及其用于治疗和预防与CAMKII活性相关的疾病和疾病的用途公开(公告)号：US20140066388A1
公开(公告)日：2014-03-06
申请号：US14017847
申请日：2013-09-04
Applicant: University of Iowa Research Foundation
Inventor： Mark E. Anderson , Mei-ling A. Joiner , Aliasger K. Salem , Amaraporn Wongrakpanich , Frederick E. Domann , Duane D. Hall , Olha M. Koval , Douglas R. Spitz
IPC: A61K47/42
CPC classification number: A61K47/42 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K38/1709 , A61K47/62 , A61K47/6935 , A61K47/6937 , A61K2300/00
Abstract: Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.
Abstract translation: 公开了用于治疗或预防与线粒体CaMKII活性相关的疾病或病症的组合物和方法。
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Patent Agency Ranking
公开(公告)号：US11596613B2
公开(公告)日：2023-03-07
申请号：US16945327
申请日：2020-07-31
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz
IPC: A61K31/192 , A61K31/437 , A61K31/4706 , A61K31/662 , A61P35/00 , A61K31/66 , A61K39/395 , C07K16/28
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
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公开(公告)号：US20210113503A1
公开(公告)日：2021-04-22
申请号：US16945327
申请日：2020-07-31
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz
IPC: A61K31/192 , A61K31/437 , A61K31/4706 , A61K31/662 , A61P35/00 , A61K31/66 , A61K39/395 , C07K16/28
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with a GSH synthesis inhibitor and an anti-cancer composition.
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公开(公告)号：US20200147060A1
公开(公告)日：2020-05-14
申请号：US16668736
申请日：2019-10-30
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Michael K. Schultz , Somya Kapoor , Douglas R. Spitz , Andrean Burnett , Ling Yang
IPC: A61K31/437 , A61K31/197 , A61K31/192 , A61K31/472 , A61P35/00
Abstract: The invention provides in certain embodiments a therapeutic regimen comprising (a) an anti-cancer combination of vemurafenib and cobimetinib, or a combination of trametinib and dabrafenib, and (b) a secondary agent comprising L-buthionine-[S,R]-sulfoximine (BSO), or phenyl butyric acid (PBA) or a pharmaceutically acceptable salt thereof, and chloroquine or hydrochloroquine (HCQ) for the therapeutic treatment of a hyperproliferative disorder.
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公开(公告)号：US20170100370A1
公开(公告)日：2017-04-13
申请号：US15291833
申请日：2016-10-12
Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION
Inventor： Bryan G. Allen , Douglas R. Spitz , Garry R. Buettner , Joseph Cullen , Joshua Schoenfeld , Michael Schultz , Fenghuang Zhan
IPC: A61K31/375 , A61K31/337 , A61K31/282 , A61N5/10 , A61K31/704 , A61K31/7068 , A61K31/295 , A61K45/06 , A61K9/00
CPC classification number: A61K31/375 , A61K9/0019 , A61K31/198 , A61K31/282 , A61K31/295 , A61K31/337 , A61K31/555 , A61K31/704 , A61K31/7068 , A61K45/06 , A61K47/22 , A61N2005/1098 , A61K2300/00
Abstract: The invention provides compositions and methods to treat a hyperproliferative disorder with ascorbate or a pharmaceutically acceptable salt thereof, at least one chelating agent that enhances ascorbate redox cycling (EDTA) to form H2O2, and one or more anti-cancer therapies.
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9.发明授权Mitochondrial-targeted cationic nanoparticles comprising CaMKII inhibitors and uses thereof for treating and preventing diseases and disorders associated with CaMKII activity 有权包含CaMKII抑制剂的线粒体靶向阳离子纳米颗粒及其用于治疗和预防与CaMKII活性相关的疾病和病症的用途公开(公告)号：US09168307B2
公开(公告)日：2015-10-27
申请号：US14017847
申请日：2013-09-04
Applicant: University of Iowa Research Foundation
Inventor： Mark E. Anderson , Mei-ling A. Joiner , Aliasger K. Salem , Amaraporn Wongrakpanich , Frederick E. Domann , Duane D. Hall , Olha M. Koval , Douglas R. Spitz
CPC classification number: A61K47/42 , A61K9/5123 , A61K9/5146 , A61K9/5153 , A61K38/1709 , A61K47/62 , A61K47/6935 , A61K47/6937 , A61K2300/00
Abstract: Disclosed are compositions and methods for treating or preventing diseases or disorders associated with mitochondrial CaMKII activity.
Abstract translation: 公开了用于治疗或预防与线粒体CaMKII活性相关的疾病或病症的组合物和方法。
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