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    Methods for ultraviolet excitation microscopy of biological surfaces
    2.
    发明授权
    Methods for ultraviolet excitation microscopy of biological surfaces 有权

    公开(公告)号：US11860100B2

    公开(公告)日：2024-01-02

    申请号：US16964831

    申请日：2019-01-25

    Applicant: UNIVERSITY OF ROCHESTER

    Inventor： Stavros G. Demos ,  Chi Huang

    IPC: G01N21/64 ,  G01N1/30

    CPC classification number: G01N21/6458 ,  G01N1/30 ,  G01N2001/302

    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

    METHODS FOR ULTRAVIOLET EXCITATION MICROSCOPY OF BIOLOGICAL SURFACES
    3.
    发明申请
    METHODS FOR ULTRAVIOLET EXCITATION MICROSCOPY OF BIOLOGICAL SURFACES 有权

    公开(公告)号：US20210063312A1

    公开(公告)日：2021-03-04

    申请号：US16964831

    申请日：2019-01-25

    Applicant: UNIVERSITY OF ROCHESTER

    Inventor： Stavros G. Demos ,  Chi Huang

    IPC: G01N21/64 ,  G01N1/30

    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limtiation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

    METHODS FOR ULTRAVIOLET EXCITATION MICROSCOPY OF BIOLOGICAL SURFACES
    4.
    发明公开
    METHODS FOR ULTRAVIOLET EXCITATION MICROSCOPY OF BIOLOGICAL SURFACES 审中-公开

    公开(公告)号：US20240085330A1

    公开(公告)日：2024-03-14

    申请号：US18515408

    申请日：2023-11-21

    Applicant: UNIVERSITY OF ROCHESTER

    Inventor： Stavros G. Demos ,  Chi Huang

    IPC: G01N21/64 ,  G01N1/30

    CPC classification number: G01N21/6458 ,  G01N1/30 ,  G01N2001/302

    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

    Methods for ultraviolet excitation microscopy of biological surfaces
    7.
    发明授权
    Methods for ultraviolet excitation microscopy of biological surfaces 有权

    公开(公告)号：US12135288B2

    公开(公告)日：2024-11-05

    申请号：US18515408

    申请日：2023-11-21

    Applicant: UNIVERSITY OF ROCHESTER

    Inventor： Stavros G. Demos ,  Chi Huang

    IPC: G01N21/64 ,  G01N1/30

    Abstract: Microscopy with Ultraviolet Surface Excitation (MUSE) for use in the classroom to enhance life sciences education and curricula, or for other applications, including without limitation the operating room, other medical environments, research environments, and low resource environments. MUSE's suitability is based on multiple key factors including its simplicity of use, the incorporation of inexpensive hardware including LED illumination, and very basic tissue preparation. The ultraviolet excitation acts as passive optical sectioning confining the generated fluorescence signal to only a few micrometers below the tissue surface thus eliminating the out of focus signals. This facilitates image capture of tissue microstructure and organization from specimens at the intact or sliced surface arising from varying fluorophore concentration within the different cellular compartments. Although just the tissue auto fluorescence maybe used, image quality is enhanced with brief application of nontoxic fluorescent dyes to selectively highlight cellular compartments. Sample preparation is safe, efficient and familiar to students with basic chemistry or biology lab experience. Mixed-dye powders may be used to simplify translation of this method for educational, medical, research, low resource, and other settings.

    ADDITIVE MANUFACTURING SYSTEMS AND METHODS
    8.
    发明申请
    ADDITIVE MANUFACTURING SYSTEMS AND METHODS 有权

    公开(公告)号：US20210046586A1

    公开(公告)日：2021-02-18

    申请号：US16923055

    申请日：2020-07-07

    Applicant: University of Rochester

    Inventor： Kenneth L. Marshall ,  Stavros G. Demos ,  Tanya Kosc

    IPC: B23K26/342 ,  B22F3/105 ,  B29C64/153 ,  B23K26/0622 ,  B23K26/064

    Abstract: Additive manufacturing systems and methods utilizing an optical light valve configured to spatially modulate the intensity of a laser beam, in conjunction with a writing and erasing sub-system configured to repeatedly write and erase patterns in the optical light valve to repeatedly vary the spatial modulation of the laser beam. In some implementations, the systems and methods may also employ additional laser beams or other energy sources that are not spatially modulated by the optical light valve. In some implementations, the systems and methods may employ additional laser beams or other energy sources configured to reduce surface roughness of the powder or other material being used for additive manufacturing.

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