公开(公告)号：US10653750B2

公开(公告)日：2020-05-19

申请号：US15561158

申请日：2016-03-23

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Charles Joseph Lockwood ,  Umit Ali Kayisli ,  Murat Basar ,  Ozlem Guzeloglu-Kayisli ,  Nihan Semerci ,  Frederick Schatz

IPC: A61K38/19 ,  A61K45/06 ,  A61K31/57 ,  A61P15/00 ,  A61K9/00

Abstract: The present invention concerns compositions and methods for inhibition of abnormal uterine bleeding (AUB), such as that associated with use of long-acting progestin-only contraceptives (LAPCs). An aspect of the invention concerns compositions comprising chemokine (C-C motif) ligand 2 (CCL2), or a biologically active fragment thereof, which may administered to subjects for inhibition of AUB. Another aspect of the invention concerns methods for inhibiting AUB, comprising administering an effective amount of CCL2, or a biologically active fragment thereof, to a subject in need thereof. Another aspect of the invention concerns a kit for inhibiting AUB.