公开(公告)号：US11173152B1

公开(公告)日：2021-11-16

申请号：US16848929

申请日：2020-04-15

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Vijaykumar Bhadabhai Sutariya ,  Umesh Kumar Jinwal

IPC: A61K31/4439 ,  A61K9/51

Abstract: Nanoparticle based MKT formulation. MKT is encapsulated by poly(ethylene glycol)ylated (PEGylated) poly-(lactide-co-glycolide) (PLGA) to form nanoparticles (NPs). To induce trans-BBB permeability, glutathione (GSH) is coated on the resulting NPs. Newly generated MKT-NPs showed BBB permeability and tau reduction in experimental models. Specifically, brain-targeting MKT NPs were developed with a glutathione coating, characterized, and shown to permeate BBB permeation insert models as a therapeutic for Alzheimer's disease and related tauopathies.

公开(公告)号：US10653642B2

公开(公告)日：2020-05-19

申请号：US16293535

申请日：2019-03-05

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Umesh Kumar Jinwal ,  Vetriselvan Manavalan

IPC: A61K9/00 ,  A61P25/28 ,  A61K31/055

Abstract: Disclosed herein are compositions and methods for treating tauopathies such as Alzheimer's disease (AD). Also provided herein are methods of reducing or disrupting tau aggregation in a subject, and methods of reducing tau protein in a subject. The methods may include administering to the subject a therapeutic amount of hexachlorophene, or a pharmaceutically acceptable salt thereof. Further provided herein are pharmaceutical compositions comprising hexachlorophene, or a pharmaceutically acceptable salt thereof, for the treatment of a tauopathy in a subject.