公开(公告)号：US20220073874A1

公开(公告)日：2022-03-10

申请号：US17472424

申请日：2021-09-10

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Justin Ichida ,  Kimberley N. Babos ,  Kate E. Galloway

IPC: C12N5/0793 ,  C12N5/074

Abstract: The disclosure relates methods for increasing the efficiency of cellular reprogramming of somatic cells and improving the maturity of the resulting cells.

公开(公告)号：US20230098111A1

公开(公告)日：2023-03-30

申请号：US17794920

申请日：2021-01-28

Applicant: University of Southern California

Inventor： Justin Ichida ,  Uh Jin Lee ,  Manuel Santana

IPC: C12N15/113 ,  A61P25/28

Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a PIKFYVE antisense or inhibitory nucleic acid to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity and/or inhibiting the expression of PIKFYVE gene.

公开(公告)号：US20180161335A1

公开(公告)日：2018-06-14

申请号：US15579546

申请日：2016-06-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Justin Ichida ,  Shaoyu Lin ,  Yichen Li ,  Yingxiao Shi

IPC: A61K31/5377 ,  A61K31/27 ,  A61K45/06 ,  A61P25/28

CPC classification number: A61K31/5377 ,  A61K31/27 ,  A61K45/06 ,  A61P25/28

Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.

公开(公告)号：US20230066380A1

公开(公告)日：2023-03-02

申请号：US17793554

申请日：2021-01-22

Applicant: University of Southern California

Inventor： Justin Ichida ,  Gabriel Linares

IPC: C12N15/113 ,  A61P25/28

Abstract: Disclosed is a method of treating a subject who has a neurological disease. In one aspect, the method includes a step of administering an effective dose of a SYF2 antisense or inhibitory nucleic acid to a subject in need thereof, thereby restoring nuclear localization of TDP-43.

公开(公告)号：US10758545B2

公开(公告)日：2020-09-01

申请号：US15579546

申请日：2016-06-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Justin Ichida ,  Shaoyu Lin ,  Yichen Li ,  Yingxiao Shi

IPC: A61K31/5377 ,  A61P25/28 ,  A61K45/06 ,  A61K31/27

Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.