公开(公告)号：US10758545B2

公开(公告)日：2020-09-01

申请号：US15579546

申请日：2016-06-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Justin Ichida ,  Shaoyu Lin ,  Yichen Li ,  Yingxiao Shi

IPC: A61K31/5377 ,  A61P25/28 ,  A61K45/06 ,  A61K31/27

Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.

公开(公告)号：US20180161335A1

公开(公告)日：2018-06-14

申请号：US15579546

申请日：2016-06-24

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA

Inventor： Justin Ichida ,  Shaoyu Lin ,  Yichen Li ,  Yingxiao Shi

IPC: A61K31/5377 ,  A61K31/27 ,  A61K45/06 ,  A61P25/28

CPC classification number: A61K31/5377 ,  A61K31/27 ,  A61K45/06 ,  A61P25/28

Abstract: Disclosed is a method of treating a subject who has a neurological disease. The neurological disease may be associated with altered C9ORF72 protein activity. In one aspect, the method includes a step of administering an effective dose of a pharmaceutical composition to a subject in need thereof, thereby rescuing the defects associated with altered C9ORF72 protein activity. Also described are methods for identifying a compound for inhibiting motor neuron degeneration.