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公开(公告)号:US09624289B2
公开(公告)日:2017-04-18
申请号:US14539884
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US20150139995A1
公开(公告)日:2015-05-21
申请号:US14539879
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US20180016320A1
公开(公告)日:2018-01-18
申请号:US15583788
申请日:2017-05-01
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US20150197551A1
公开(公告)日:2015-07-16
申请号:US14539884
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US10822388B2
公开(公告)日:2020-11-03
申请号:US15583788
申请日:2017-05-01
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US09670265B2
公开(公告)日:2017-06-06
申请号:US14539879
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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7.
公开(公告)号:US09321824B2
公开(公告)日:2016-04-26
申请号:US14539872
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白的组合物治疗与炎症,自身免疫疾病和癌症相关的病症。
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公开(公告)号:US09228006B2
公开(公告)日:2016-01-05
申请号:US13831031
申请日:2013-03-14
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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公开(公告)号:US20150299292A1
公开(公告)日:2015-10-22
申请号:US14539872
申请日:2014-11-12
Applicant: University Health Network
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705 , A61K38/17
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
Abstract translation: 本发明进一步涉及用于调节Toso蛋白活性的方法和组合物。 本发明还包括使用包括可溶性Toso蛋白的组合物治疗与炎症,自身免疫疾病和癌症相关的病症。
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公开(公告)号:US20130281356A1
公开(公告)日:2013-10-24
申请号:US13831031
申请日:2013-03-14
Applicant: UNIVERSITY HEALTH NETWORK
Inventor: Michael W. Tusche , Tak W. Mak , Pamela S. Ohashi , Philipp Lang , Karl Lang , Dirk Brenner , Gloria Lin
IPC: C07K14/705
CPC classification number: C07K14/70503 , A61K38/1709 , A61K38/1774 , C07K14/705 , C07K2319/02 , C07K2319/30
Abstract: The present invention is further directed to methods and compositions for modulating the activity of the Toso protein. The invention further encompasses treatment of disorders associated with inflammation, autoimmune disorders, and cancer using compositions that include a soluble Toso protein.
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