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    INTEGRATED THIN-FILM OPTRODE
    1.
    发明申请
    INTEGRATED THIN-FILM OPTRODE 审中-公开

    公开(公告)号：US20180325379A1

    公开(公告)日：2018-11-15

    申请号：US15973077

    申请日：2018-05-07

    Applicant: University of Houston System ,  Vanderbilt University

    Inventor： John C. Wolfe ,  Mufaddal Gheewala ,  Wei-Chuan Shih ,  Gopathy Purushothaman

    IPC: A61B5/00 ,  H01L33/38 ,  H01L31/0224 ,  A61B5/04

    CPC classification number: A61B5/0084 ,  A61B5/04001 ,  A61B5/4064 ,  A61B2562/12 ,  H01L31/022408 ,  H01L33/382

    Abstract: An optrode may provide a cylindrical substrate two or more electrodes deposited said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may be exposed ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define vias regions in which portions of the electrodes are exposed and uncoated by an insulating layer.

    Fabrication and applications of multiple side-window, side-firing optical fiber
    5.
    发明授权
    Fabrication and applications of multiple side-window, side-firing optical fiber 有权

    公开(公告)号：US11124449B2

    公开(公告)日：2021-09-21

    申请号：US16326986

    申请日：2017-08-31

    Applicant: University of Houston System

    Inventor： Wei-Chuan Shih

    IPC: C03C25/6208 ,  C03C25/106 ,  C03C25/68 ,  F21V8/00

    Abstract: The present disclosure relates to the fabrication and characterization of an optical fiber capable of firing light virtually from any point along its circumferential surface. The optical fiber is preferably prepared by laser micromachining. In preferred embodiments, laser radiation is focused onto a multimode optical fiber axis, forming a conical-shaped cavity (side window) in the fiber core. Because of the total internal reflection when the laser beam reaches the side window-outside medium interface, the beam is reflected to the side of the optical fiber.

    Nanoporous gold and silver nanoparticles and substrates for molecular and biomolecular sensing
    8.
    发明授权
    Nanoporous gold and silver nanoparticles and substrates for molecular and biomolecular sensing 有权

    公开(公告)号：US10961564B2

    公开(公告)日：2021-03-30

    申请号：US15314219

    申请日：2015-05-22

    Applicant: UNIVERSITY OF HOUSTON SYSTEM

    Inventor： Wei-Chuan Shih ,  Richard Willson

    IPC: C12Q1/6816 ,  G01N21/65 ,  G01N21/64 ,  G01N21/552 ,  G01N33/543 ,  G01N33/553

    Abstract: A methodology for assays and diagnostics utilizes a nanoporous or corrugated metal-containing surface, fiber or particle which enhances or suppresses the optical detectability of a label. The resulting optical, electromagnetic, or imaging signal signals the presence of a pathogen or analyte of interest. Preferred embodiments pertain to label-free, in situ monitoring of individual DNA hybridization in microfluidics using molecular sentinel probes immobilized on nanoporous gold disks. By immobilizing molecular sentinel probes on nanoporous gold disks, single-molecule sensitivity is demonstrated via surface-enhanced Raman scattering which provides robust signals. The described methodology is generally applicable to most amplification independent assays and molecular diagnostics.

    Integrated thin-film optrode
    9.
    发明授权
    Integrated thin-film optrode 有权

    公开(公告)号：US10806358B2

    公开(公告)日：2020-10-20

    申请号：US15973077

    申请日：2018-05-07

    Applicant: University of Houston System ,  Vanderbilt University

    Inventor： John C. Wolfe ,  Mufaddal Gheewala ,  Wei-Chuan Shih ,  Gopathy Purushothaman

    IPC: A61B5/04 ,  A61B5/0478 ,  A61B5/00 ,  H01L31/0224 ,  H01L33/38

    Abstract: An optrode may provide a cylindrical substrate with two or more electrodes deposited on said cylindrical substrate. The cylindrical substrate and electrodes may be coated by an insulating layer with openings or vias over certain portions of the electrodes that may provide a contact for the neural probe or may be utilized to connect lead lines. Manufacturing of an optrode may utilize a jig that secures a cylindrical substrate coated by a conductive material and a resist. A first mask may be positioned in an opening provided by the jig, and the cylindrical substrate may expose ions or neutral particles to define one or more electrode patterns. After regions of the resist and conductive material are removed to form the electrodes, a second mask may be utilized to define via regions in which portions of the electrodes are exposed and uncoated by an insulating layer.

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