公开(公告)号：US10760893B2

公开(公告)日：2020-09-01

申请号：US15334648

申请日：2016-10-26

Applicant: University of Kent at Canterbury

Inventor： Adrian Podoleanu ,  Sylvain Rivet ,  Adrian Bradu ,  Michael Maria

IPC: G01B9/02

Abstract: The present invention related to an apparatus and method for master slave interferometry, referred to as Complex Master Slave (CMS). The method and apparatus can be used to provide complex-valued measurements of a signal reflected from an axial position inside an object or of signals reflected from points at several axial positions inside an object.

公开(公告)号：US20200037871A1

公开(公告)日：2020-02-06

申请号：US16521859

申请日：2019-07-25

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Manuel Marques ,  Michael Hughes

IPC: A61B3/10 ,  G01N21/47 ,  A61B3/00 ,  A61B5/00

Abstract: The present disclosure relates to an apparatus and method that can be used to remotely acquire high resolution depth resolved images from a sample. The apparatus employs an adapter to an imaging device, where the adapter uses a minimum of components to produce interferometry patterns on the input facet of the imaging device. The imaging device can be a bundle endoscope terminated on a camera sensor or on several camera sensors or simply a camera sensor. In conjunction with a swept source or a broadband source, at least one camera sensor may be employed to provide optical coherence tomography (OCT) images of the sample. When the imaging device uses a bundle of optical fibers, the apparatus and method can provide OCT images tolerant to bending of the bundle.

公开(公告)号：US20230324166A1

公开(公告)日：2023-10-12

申请号：US18022307

申请日：2021-08-19

Applicant: University of Kent at Canterbury

Inventor： Adrian Podoleanu

IPC: G01B9/02091 ,  G02B21/36 ,  G02B21/00

CPC classification number: G01B9/02091 ,  G02B21/361 ,  G02B21/008

Abstract: Methods and devices are disclosed to perform depth resolved imaging using parallel lateral detection employing a photodetector block in a detection path that is substantially perpendicular to the direction of light excitation, with applications in microscopy of samples. The photodetector block either comprises a single 1D array of photodetectors or a 2D array of photodetectors. Methods and devices are disclosed to perform coherence gating in configurations of light sheet tomography, to enable simultaneous depth resolved measurements of structure and of index of refraction variation.

公开(公告)号：US11717154B2

公开(公告)日：2023-08-08

申请号：US16521859

申请日：2019-07-25

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Manuel Marques ,  Michael Hughes

IPC: A61B3/10 ,  A61B3/00 ,  A61B5/00 ,  G01N21/47

CPC classification number: A61B3/102 ,  A61B3/0008 ,  A61B5/0066 ,  G01N21/4795

Abstract: The present disclosure relates to an apparatus and method that can be used to remotely acquire high resolution depth resolved images from a sample. The apparatus employs an adapter to an imaging device, where the adapter uses a minimum of components to produce interferometry patterns on the input facet of the imaging device. The imaging device can be a bundle endoscope terminated on a camera sensor or on several camera sensors or simply a camera sensor. In conjunction with a swept source or a broadband source, at least one camera sensor may be employed to provide optical coherence tomography (OCT) images of the sample. When the imaging device uses a bundle of optical fibers, the apparatus and method can provide OCT images tolerant to bending of the bundle.

公开(公告)号：US20210145285A1

公开(公告)日：2021-05-20

申请号：US16951442

申请日：2020-11-18

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Manuel Marques ,  Adrian Bradu ,  Adrian Fernandez Uceda

IPC: A61B5/00 ,  A61B5/16 ,  G01B9/02

Abstract: The present specification relates to Master-Slave (MS) interferometry for sensing the axial position of an object subject to optical coherence tomography (OCT) imaging, and to MS-OCT applied to curved and axially moving objects. The methods and apparatuses allow producing OCT signals from selected depths within the object irrespective of its axial position in respect to the imaging system. Images are obtained for curved objects that are flattened along a layer of interest in the object, images that are used to provide OCT angiography images less disturbed by axial movement or lateral scanning.

公开(公告)号：US10211594B2

公开(公告)日：2019-02-19

申请号：US14882885

申请日：2015-10-14

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Radu-Florin Stancu

IPC: H01S3/11 ,  H01S3/10 ,  H01S3/067 ,  H01S5/065 ,  H01S5/14 ,  H01S3/08

Abstract: A detuned resonant mechanism is employed in a laser cavity to modulate in frequency the mode-locking mechanism to achieve high frequency tuning rates, exceeding MHz. The configuration of the laser is compatible with working at sweeping rates close to multiples of the cavity resonance frequency as well as with buffering for increased tuning speeds.

公开(公告)号：US11690516B2

公开(公告)日：2023-07-04

申请号：US16951442

申请日：2020-11-18

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Manuel Marques ,  Adrian Bradu ,  Adrian Fernandez Uceda

IPC: A61B5/00 ,  G01B9/02091 ,  A61B5/16 ,  G01B9/02055 ,  G01B9/02

CPC classification number: A61B5/0066 ,  A61B5/0082 ,  A61B5/163 ,  A61B5/7257 ,  G01B9/02077 ,  G01B9/02088 ,  G01B9/02091

Abstract: The present specification relates to Master-Slave (MS) interferometry for sensing the axial position of an object subject to optical coherence tomography (OCT) imaging, and to MS-OCT applied to curved and axially moving objects. The methods and apparatuses allow producing OCT signals from selected depths within the object irrespective of its axial position in respect to the imaging system. Images are obtained for curved objects that are flattened along a layer of interest in the object, images that are used to provide OCT angiography images less disturbed by axial movement or lateral scanning.

公开(公告)号：US09383187B2

公开(公告)日：2016-07-05

申请号：US14440278

申请日：2013-11-01

Applicant: University of Kent

Inventor： Adrian Podoleanu ,  Adrian Bradu

IPC: G01J3/45 ,  G01B9/02

CPC classification number: G01B9/02044 ,  G01B9/02004 ,  G01B9/02064 ,  G01B9/02088 ,  G01B9/02091 ,  G01B2290/60

Abstract: Real-time depth measurements in sensing in spectral domain interferometry and for en-face and cross section image production in optical coherence tomography can operate without any need to linearize the data to maximize the output signal and achieve the theoretical depth resolution. Novel interferometry is disclosed, where parameters of a master interferometer dictate the results in a slave interferometer. The master interferometer can be the same measuring interferometer used in two stages. The master interferometer parameters are at least optical path difference (OPD) or the speed of variation of the OPD in the master interferometer. Coherence gated data are produced from selected axial positions which can be from positive or negative optical path differences, in parallel, enabling generation of en-face (C-scan) OCT images simultaneously from several depths, free from mirror terms, and production of A-scans and B-scan OCT images using plural reflectivity values measured in parallel from different depths within A-scans.

Abstract translation: 在光学相干断层扫描中的频域干涉测量和面内和横截面图像生成中的实时深度测量可以在不需要线性化数据以使输出信号最大化并达到理论深度分辨率的情况下工作。 公开了新型干涉测量法，其中主干涉仪的参数决定了从属干涉仪中的结果。 主干涉仪可以是两个相同的测量干涉仪。 主干涉仪参数至少在主干涉仪中的光程差（OPD）或OPD的变化速度。 从选择的轴向位置产生相干门控数据，该轴向位置可以是平行的正或负光程差，从而能够从几个深度同时生成面对（C扫描）OCT图像，没有镜像条件，并且产生A 扫描和B扫描OCT图像，使用在A扫描内从不同深度并行测量的多个反射率值。

公开(公告)号：US09167144B2

公开(公告)日：2015-10-20

申请号：US14102148

申请日：2013-12-10

Applicant: UNIVERSITY OF KENT

Inventor： Adrian Podoleanu

IPC: H04N5/232 ,  A61B3/10 ,  G02B21/00 ,  G01B9/02 ,  A61B3/14 ,  H04N5/225 ,  H04N5/33

CPC classification number: H04N5/232 ,  A61B3/102 ,  A61B3/14 ,  G01B9/02007 ,  G01B9/0203 ,  G01B9/02049 ,  G01B9/02069 ,  G01B9/02079 ,  G01B9/02091 ,  G01B2290/35 ,  G01B2290/70 ,  G02B21/0056 ,  G02B21/0064 ,  H04N5/2252 ,  H04N5/33

Abstract: The invention describes several embodiments of an adapter which can make use of the devices in any commercially available digital cameras to transform the digital camera into a fundus camera for inspecting the back of the eye, or into a microscope. The camera adapter is adapted to be placed between the camera device and the object. The devices in the camera being used are at least its optical source, photodetector sensor, memory, shutter and autofocus. Means in the adapter are provided to employ these devices and allow camera to operate its autofocus capability and its different color sensors. Methods of investigation of an object are also presented of using the adapter to transform the camera into an imaging instrument, where the effect of adjustments of elements inside the adapter are guided by the displaying screen of the camera.

Abstract translation: 本发明描述了适配器的几个实施例，其可以利用任何市售数字照相机中的装置将数字照相机转换成眼底照相机，以检查眼睛后部或显微镜。 相机适配器适于放置在相机设备和对象之间。 正在使用的相机中的设备至少是其光源，光电检测器传感器，存储器，快门和自动对焦。 提供适配器中的装置以使用这些装置并允许相机操作其自动对焦能力及其不同的颜色传感器。 还提出了使用适配器将相机变换成成像仪器的对象的调查方法，其中适配器内的元件的调整效果由照相机的显示屏幕引导。

公开(公告)号：US20150292860A1

公开(公告)日：2015-10-15

申请号：US14440278

申请日：2013-11-11

Applicant: UNIVERSITY OF KENT

Inventor： Adrian Podoleanu ,  Adrian Bradu

IPC: G01B9/02

CPC classification number: G01B9/02044 ,  G01B9/02004 ,  G01B9/02064 ,  G01B9/02088 ,  G01B9/02091 ,  G01B2290/60

Abstract: Real-time depth measurements in sensing in spectral domain interferometry and for en-face and cross section image production in optical coherence tomography can operate without any need to linearize the data to maximize the output signal and achieve the theoretical depth resolution. Novel interferometry is disclosed, where parameters of a master interferometer dictate the results in a slave interferometer. The master interferometer can be the same measuring interferometer used in two stages. The master interferometer parameters are at least optical path difference (OPD) or the speed of variation of the OPD in the master interferometer. Coherence gated data are produced from selected axial positions which can be from positive or negative optical path differences, in parallel, enabling generation of en-face (C-scan) OCT images simultaneously from several depths, free from mirror terms, and production of A-scans and B-scan OCT images using plural reflectivity values measured in parallel from different depths within A-scans.

Abstract translation: 在光学相干断层扫描中的频域干涉测量和面内和横截面图像生成中的实时深度测量可以在不需要线性化数据以使输出信号最大化并达到理论深度分辨率的情况下工作。 公开了新型干涉测量法，其中主干涉仪的参数决定了从属干涉仪中的结果。 主干涉仪可以是两个相同的测量干涉仪。 主干涉仪参数至少在主干涉仪中的光程差（OPD）或OPD的变化速度。 从选择的轴向位置产生相干门控数据，该轴向位置可以是平行的正或负光程差，从而能够从几个深度同时生成面对（C扫描）OCT图像，没有镜像条件，并且产生A 扫描和B扫描OCT图像，使用在A扫描内从不同深度并行测量的多个反射率值。