公开(公告)号：US12066362B2

公开(公告)日：2024-08-20

申请号：US17239387

申请日：2021-04-23

Applicant: University of Washington

Inventor： Thomas J. Matula ,  Karol Bomsztyk ,  Brian MacConaghy ,  Justin Reed ,  Adam D. Maxwell

IPC: B01L3/00 ,  B06B1/02 ,  B06B1/06 ,  C12M1/00 ,  G01N1/28 ,  G10K11/30

CPC classification number: G01N1/286 ,  B01L3/5085 ,  B06B1/0215 ,  B06B1/0629 ,  C12M47/06 ,  G10K11/30 ,  B06B2201/55 ,  B06B2201/70

Abstract: A system for processing biological or other samples includes an array of transducer elements that are positioned to align with sample wells in a microplate. Each transducer element produces ultrasound energy that is focused towards a well of the microplate with sufficient acoustic pressure to cause inertial cavitation. In one embodiment, the transducers are configured to direct ultrasound energy into cylindrical wells. In other embodiments, the transducer elements are configured to direct ultrasound energy into non-cylindrical wells of a microplate.

公开(公告)号：US20230321327A1

公开(公告)日：2023-10-12

申请号：US18297799

申请日：2023-04-10

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Yashwanth Nanda Kumar

IPC: A61L31/04 ,  A61L31/14

CPC classification number: A61L31/041 ,  A61L31/145

Abstract: A phantom for fibrous tissue, the phantom formed from a precursor solution including about 30-90 wt % of water, acrylamide, and alginate, where the acrylamide and alginate, in combination, are about 10 to 70 wt % of the precursor solution, and where a ratio of acrylamide to alginate is in the range of about 60:40 to about 99:1 w/w.

公开(公告)号：US20210187330A1

公开(公告)日：2021-06-24

申请号：US17268838

申请日：2019-08-14

Applicant: University of Washington

Inventor： Michael R. Bailey ,  Adam D. Maxwell ,  Akshay Purushottamji Randad ,  Mohamed Abdalla Ghanem

IPC: A61N7/00 ,  G16H20/40

Abstract: Apparatus and method for ultrasound beam shaping are disclosed herein. In one embodiment, an ultrasonic therapy system is configured to apply ultrasound to a target in a body. The system includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable lens configured to focus the ultrasound onto a focal area of the target. The target is an object or a portion of the object in the body. The customizable lens is designed and produced based on at least one acquired image of the target.

公开(公告)号：US10598773B2

公开(公告)日：2020-03-24

申请号：US15446923

申请日：2017-03-01

Applicant: University of Washington

Inventor： Oleg A. Sapozhnikov ,  Wayne Kreider ,  Adam D. Maxwell ,  Vera Khokhlova

IPC: G03H3/00 ,  G01S7/52 ,  G01S15/89 ,  A61B8/00 ,  A61N7/00 ,  A61N7/02

Abstract: The present technology relates generally to receiving arrays to measure a characteristic of an acoustic beam and associated systems and methods. The receiving arrays can include elongated elements having at least one dimension, such as a length, that is larger than a width of an emitted acoustic beam and another dimension, such as a width, that is smaller than half of a characteristic wavelength of an ultrasound wave. The elongated elements can be configured to capture waveform measurements of the beam based on a characteristic of the emitted acoustic beam as the acoustic beam crosses a plane of the array, such as a transverse plane. The methods include measuring at least one characteristic of an ultrasound source using an array-based acoustic holography system and defining a measured hologram at the array surface based, at least in part, on the waveform measurements. The measured hologram can be processed to reconstruct a characteristic of the ultrasound source. The ultrasound source can be calibrated and/or re-calibrated based on the characteristic.

公开(公告)号：US20170249932A1

公开(公告)日：2017-08-31

申请号：US15508841

申请日：2015-08-26

Applicant: Oleg A. SAPOZHNIKOV ,  Wayne KREIDER ,  Michael R. BAILEY ,  University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/00 ,  G10K11/30 ,  H03H9/64 ,  G10K11/20 ,  G10K11/24

CPC classification number: G10K11/008 ,  A61B17/225 ,  A61B17/2255 ,  A61B2017/22028 ,  G10K11/20 ,  G10K11/24 ,  G10K11/30 ,  G10K11/346 ,  G10K15/00 ,  H03H9/6483

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20200227018A1

公开(公告)日：2020-07-16

申请号：US16740320

申请日：2020-01-10

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: G10K11/00 ,  G10K11/30 ,  G10K15/00 ,  A61B17/225 ,  G10K11/34 ,  G10K11/20 ,  G10K11/24 ,  H03H9/64

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens includes a plurality of segments. Each of the plurality of segments has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20200222728A1

公开(公告)日：2020-07-16

申请号：US16712680

申请日：2019-12-12

Applicant: UNIVERSITY OF WASHINGTON ,  KONINKLIJKE PHILIPS N.V., A CORPORPORATION ORGANIZED AND EXISTING UNDER THE LAWS OF KINGDOM OF THE

Inventor： Vera Khokhlova ,  Michael R. Bailey ,  Navid Farr ,  Tatiana D. Khokhlova ,  Wayne Kreider ,  Adam D. Maxwell ,  Ari Partanen ,  Oleg A. Sapozhnikov ,  George R. Schade ,  Yak-Nam Wang

IPC: A61N7/02

Abstract: An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

公开(公告)号：US10535332B2

公开(公告)日：2020-01-14

申请号：US15508841

申请日：2015-08-26

Applicant: University of Washington

Inventor： Adam D. Maxwell ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Michael R. Bailey

IPC: H01L41/09 ,  G10K11/00 ,  G10K11/30 ,  G10K15/00 ,  G10K11/20 ,  G10K11/24 ,  H03H9/64 ,  A61B17/225 ,  G10K11/34 ,  A61B17/22

Abstract: A method includes transmitting a focused ultrasound wave into a medium to form (i) an ultrasound intensity well within the medium that exhibits a first range of acoustic pressure and (ii) a surrounding region of the medium that surrounds the ultrasound intensity well and exhibits a second range of acoustic pressure that exceeds the first range of acoustic pressure. The method further includes confining an object within the ultrasound intensity well. Additionally, an acoustic lens is configured to be acoustically coupled to an acoustic transducer. The acoustic lens has a varying longitudinal thickness that increases proportionally with respect to increasing azimuth angle of the acoustic lens. Another acoustic lens is configured to be acoustically coupled to an acoustic that increases proportionally with respect to increasing azimuth angle of the segment.

公开(公告)号：US20190117243A1

公开(公告)日：2019-04-25

申请号：US16169945

申请日：2018-10-24

Applicant: University of Washington

Inventor： Tatiana Khokhlova ,  Vera Khoklova ,  Oleg A. Sapozhnikov ,  Wayne Kreider ,  Adam D. Maxwell ,  Joo Ha Hwang

IPC: A61B17/22 ,  A61N7/00

Abstract: Apparatus and method for improved cavitation-induced drug delivery is disclosed. In one embodiment, a method for delivering a treatment composition to a target tissue using ultrasound includes: directing ultrasound waveforms toward the target tissue of a patient; generating ultrasound shock fronts at the target tissue of a patient; generating a cavitation inside the target tissue of a patient by the ultrasound shock front; and delivering the treatment composition to the patient. Absorption of the treatment composition by the target tissue is increased by the cavitation inside the target tissue. In some embodiments, the treatment composition may be delivered within a time period of +/−1 week from generating the cavitation.

公开(公告)号：US12285636B2

公开(公告)日：2025-04-29

申请号：US17881026

申请日：2022-08-04

Applicant: University of Washington

Inventor： Michael R. Bailey ,  Mohamed Abdalla Ghanem ,  Adam D. Maxwell

IPC: A61N7/00 ,  B29D11/00 ,  G02B5/32

Abstract: Non-planar holographic beam shaping lenses for acoustics are disclosed herein. In one embodiment, an ultrasonic therapy system that is configured to apply ultrasound to a target in a body includes: an ultrasonic transducer configured to generate the ultrasound; and a customizable holographic lens configured to focus the ultrasound onto a focal area of a target that is an object or a portion of the object in the body. The customizable holographic lens is designed and produced based on the target. Furthermore, the customizable holographic lens is curved to mate with a front surface of the ultrasonic transducer.