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    Methods and systems for image data processing
    2.
    发明授权
    Methods and systems for image data processing 有权
    图像数据处理的方法和系统

    公开(公告)号：US08031918B2

    公开(公告)日：2011-10-04

    申请号：US11534166

    申请日：2006-09-21

    Applicant: Wayne D. Roth

    Inventor： Wayne D. Roth

    IPC: G06K9/00

    CPC classification number: G06K9/0014 ,  G01N15/1463 ,  G06T7/0012 ,  G06T7/194 ,  G06T2207/10064 ,  G06T2207/20021 ,  G06T2207/30024 ,  G06T2207/30072

    Abstract: Methods, storage mediums, and systems for image data processing are provided. Embodiments for the methods, storage mediums, and systems include configurations to perform one or more of the following steps: background signal measurement, particle identification using classification dye emission and cluster rejection, inter-image alignment, inter-image particle correlation, fluorescence integration of reporter emission, and image plane normalization.

    Abstract translation: 提供了图像数据处理的方法，存储介质和系统。 用于方法，存储介质和系统的实施例包括执行以下一个或多个步骤的配置：背景信号测量，使用分类染料发射和簇排斥的粒子识别，图像间对准，图像间粒子相关，荧光整合 记者发射和图像平面归一化。

    Methods and systems for image data processing
    3.
    发明授权
    Methods and systems for image data processing 有权
    图像数据处理的方法和系统

    公开(公告)号：US08542897B2

    公开(公告)日：2013-09-24

    申请号：US13236269

    申请日：2011-09-19

    Applicant: Wayne D. Roth

    Inventor： Wayne D. Roth

    IPC: G06K9/00

    CPC classification number: G06K9/0014 ,  G01N15/1463 ,  G06T7/0012 ,  G06T7/194 ,  G06T2207/10064 ,  G06T2207/20021 ,  G06T2207/30024 ,  G06T2207/30072

    Abstract: Methods, storage mediums, and systems for image data processing are provided. Embodiments for the methods, storage mediums, and systems include configurations to perform one or more of the following steps: background signal measurement, particle identification using classification dye emission and cluster rejection, inter-image alignment, inter-image particle correlation, fluorescence integration of reporter emission, and image plane normalization.

    Abstract translation: 提供了图像数据处理的方法，存储介质和系统。 用于方法，存储介质和系统的实施例包括执行以下一个或多个步骤的配置：背景信号测量，使用分类染料发射和簇排斥的粒子识别，图像间对准，图像间粒子相关，荧光整合 记者发射和图像平面归一化。

    Flow cytometer and fluidic line assembly with multiple injection needles
    4.
    发明授权
    Flow cytometer and fluidic line assembly with multiple injection needles 有权
    流式细胞仪和具有多个注射针的流体线组件

    公开(公告)号：US08394326B2

    公开(公告)日：2013-03-12

    申请号：US13271569

    申请日：2011-10-12

    Applicant: Jarden E. Krager ,  William R. Deicher ,  Adam Richard Schilffarth ,  Paul Pempsell ,  Wayne D. Roth

    Inventor： Jarden E. Krager ,  William R. Deicher ,  Adam Richard Schilffarth ,  Paul Pempsell ,  Wayne D. Roth

    IPC: G01N21/01

    CPC classification number: G01N15/1404 ,  G01N21/6428 ,  G01N21/76 ,  G01N2015/1409 ,  Y10T137/0352 ,  Y10T137/85986 ,  Y10T436/2575

    Abstract: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.

    Abstract translation: 提供了流式细胞仪，其包括询问流动池和延伸到询问流动池中的多个测定流体线。 操作这种流式细胞计数器的方法包括用鞘液灌注询问流动池，并将不同的分析流体注入穿过多条流体管线的鞘液流。 提供流体线组件，其包括多个毛细管，所述多个毛细管耦合到构造成耦合到流式细胞仪的询问流动池组件的基部。 毛细管的尺寸构造使得当流体线组件布置在流式细胞计数器内并且流体从一个或多个毛细管以相对于询问流动池内的包围护套流体的给定压力差分配时，流体 在询问流动池内基本集中对齐。

    Methods and systems for dynamic range expansion
    5.
    发明授权
    Methods and systems for dynamic range expansion 有权
    动态范围扩展的方法和系统

    公开(公告)号：US07505131B2

    公开(公告)日：2009-03-17

    申请号：US12043312

    申请日：2008-03-06

    Applicant: Wayne D. Roth

    Inventor： Wayne D. Roth

    IPC: G01J3/30 ,  G01J3/40

    CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G01N15/14

    Abstract: Methods and systems for expanding the dynamic range of a system are provided. One method includes splitting fluorescent light emitted by a particle into multiple light paths having different intensities, detecting the fluorescent light in the multiple light paths with different channels to generate multiple signals, and determining which of the channels is operating in a linear range based on the multiple signals. The method also includes altering the signal generated by the channel operating in the linear range to compensate for the different intensities. Another method includes illuminating a particle in multiple illumination zones with light having different intensities and separately detecting fluorescent light emitted by the particle while located in the multiple illumination zones to generate multiple signals. The method also includes determining which of the signals is located in a linear range and altering the signal located in the linear range to compensate for the different intensities.

    Abstract translation: 提供了扩展系统动态范围的方法和系统。 一种方法包括将由颗粒发射的荧光分成具有不同强度的多个光路，检测具有不同通道的多个光路中的荧光以产生多个信号，以及基于以下步骤确定哪个通道在线性范围内操作 多个信号。 该方法还包括改变由在线性范围中操作的通道产生的信号以补偿不同的强度。 另一种方法包括用具有不同强度的光照射多个照明区域中的颗粒，并分别检测位于多个照明区域中的颗粒发射的荧光，以产生多个信号。 该方法还包括确定哪个信号位于线性范围内并且改变位于线性范围内的信号以补偿不同的强度。

    FLOW CYTOMETER AND FLUIDIC LINE ASSEMBLY WITH MULTIPLE INJECTION NEEDLES
    7.
    发明申请
    FLOW CYTOMETER AND FLUIDIC LINE ASSEMBLY WITH MULTIPLE INJECTION NEEDLES 有权
    流量计和流体线组装多个注射针

    公开(公告)号：US20120028366A1

    公开(公告)日：2012-02-02

    申请号：US13271569

    申请日：2011-10-12

    Applicant: Jarden E. Krager ,  William R. Deicher ,  Adam Richard Schilffarth ,  Paul Pempsell ,  Wayne D. Roth

    Inventor： Jarden E. Krager ,  William R. Deicher ,  Adam Richard Schilffarth ,  Paul Pempsell ,  Wayne D. Roth

    IPC: G01N21/76 ,  G01N21/64

    CPC classification number: G01N15/1404 ,  G01N21/6428 ,  G01N21/76 ,  G01N2015/1409 ,  Y10T137/0352 ,  Y10T137/85986 ,  Y10T436/2575

    Abstract: A flow cytometer is provided which includes an interrogation flow cell and a plurality of assay fluidic lines extending into the interrogation flow cell. A method of operating such a flow cytometer includes priming the interrogation flow cell with a sheath fluid and injecting different assay fluids into a flow of the sheath fluid through the plurality of fluidic lines. A fluidic line assembly is provided which includes a plurality of capillary tubes coupled to a base section configured for coupling to an interrogation flow cell assembly of a flow cytometer. The capillary tubes are dimensionally configured such that when the fluidic line assembly is arranged within the flow cytometer and fluid is dispensed from one or more of the capillary tubes at a given pressure differential with respect to an encompassing sheath fluid within the interrogation flow cell the fluid is substantially centrally aligned within the interrogation flow cell.

    Abstract translation: 提供了流式细胞仪，其包括询问流动池和延伸到询问流动池中的多个测定流体线。 操作这种流式细胞计数器的方法包括用鞘液灌注询问流动池，并将不同的分析流体注入穿过多条流体管线的鞘液流。 提供流体线组件，其包括多个毛细管，所述多个毛细管耦合到构造成耦合到流式细胞仪的询问流动池组件的基部。 毛细管的尺寸构造使得当流体线组件布置在流式细胞计数器内时，并且流体从一个或多个毛细管以相对于询问流动池内的包围护套流体的给定压差来分配时，流体 在询问流动池内基本集中对齐。

    Methods and Systems for Image Data Processing
    9.
    发明申请
    Methods and Systems for Image Data Processing 有权
    图像数据处理方法与系统

    公开(公告)号：US20120002875A1

    公开(公告)日：2012-01-05

    申请号：US13236299

    申请日：2011-09-19

    Applicant: Wayne D. Roth

    Inventor： Wayne D. Roth

    IPC: G06K9/00

    CPC classification number: G06K9/0014 ,  G01N15/1463 ,  G06T7/0012 ,  G06T7/194 ,  G06T2207/10064 ,  G06T2207/20021 ,  G06T2207/30024 ,  G06T2207/30072

    Abstract: Methods, storage mediums, and systems for image data processing are provided. Embodiments for the methods, storage mediums, and systems include configurations to perform one or more of the following steps: background signal measurement, particle identification using classification dye emission and cluster rejection, inter-image alignment, inter-image particle correlation, fluorescence integration of reporter emission, and image plane normalization.

    Abstract translation: 提供了图像数据处理的方法，存储介质和系统。 用于方法，存储介质和系统的实施例包括执行以下一个或多个步骤的配置：背景信号测量，使用分类染料发射和簇排斥的粒子识别，图像间对准，图像间粒子相关，荧光整合 记者发射和图像平面归一化。

    Light emitting diode based measurement systems
    10.
    发明授权
    Light emitting diode based measurement systems 有权
    基于发光二极管的测量系统

    公开(公告)号：US07692773B2

    公开(公告)日：2010-04-06

    申请号：US10896181

    申请日：2004-07-21

    Applicant: Wayne D. Roth

    Inventor： Wayne D. Roth

    IPC: G01P3/36

    CPC classification number: G01N15/1434

    Abstract: Various light emitting diode (LED) based measurement systems and methods are provided. One system includes one or more arrays of LEDs arranged along a flow path of a sample. The array(s) are configured to illuminate the sample as the sample moves along the flow path. The system also includes one or more detectors configured to detect light resulting from illumination of the sample by the array(s). One method includes illuminating a microsphere at different positions along a flow path of the microsphere. The method also includes detecting light resulting from the illumination to produce individual output signals corresponding to the illumination at the different positions. The method further includes combining the individual output signals to produce a single output signal having a signal-to-noise ratio that is greater than a signal-to-noise ratio of the individual output signals.

    Abstract translation: 提供了各种基于发光二极管（LED）的测量系统和方法。 一个系统包括沿着样品的流动路径布置的一个或多个LED阵列。 阵列被配置为当样品沿着流动路径移动时照亮样品。 该系统还包括一个或多个检测器，其被配置为检测由阵列照射样品产生的光。 一种方法包括沿着微球的流动路径在不同位置照射微球。 该方法还包括检测由照明产生的光以产生对应于不同位置处的照明的各个输出信号。 该方法还包括组合各个输出信号以产生具有大于各个输出信号的信噪比的信噪比的单个输出信号。

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