公开(公告)号：US10823664B2

公开(公告)日：2020-11-03

申请号：US16446750

申请日：2019-06-20

Applicant: Wisconsin Alumni Research Foundation

Inventor： Darien James Morrow ,  Daniel David Kohler ,  John Curtis Wright

IPC: G01N21/25 ,  G01N21/63 ,  G01N21/17

Abstract: Methods for pump-probe spectroscopy are provided. In an embodiment, such a method comprises directing pump light having a frequency ωpump at a location in a sample to excite a transition between two quantum states of a target entity in the sample, directing probe light at the location to generate a coherent output signal having a frequency ωoutput and a wavevector koutput, and detecting the output signal as the probe light is scanned over a range of frequencies. In the method, either the transition excited by the pump light is a multiphoton transition corresponding to a frequency difference of n*ωpump, wherein n≥2; or the probe light is a set of m coherent light pulses, each coherent light pulse having a frequency ωm and a wavevector km, wherein m≥2; or both. Systems for carrying out the methods are also provided.

公开(公告)号：US20210372918A1

公开(公告)日：2021-12-02

申请号：US17329454

申请日：2021-05-25

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright

IPC: G01N21/31

Abstract: A method for coherent multidimensional spectroscopy may comprise illuminating a location in a sample with a set of m coherent light pulses, each coherent light pulse having an initial frequency ωm and an initial wave vector {right arrow over (k)}m, wherein m≥2, to generate a coherent output signal having an initial frequency ωoutput=Σ±ωm and an initial wavevector wave vector {right arrow over (k)}output=Σ±{right arrow over (k)}m; scanning a first coherent light pulse of the set of m coherent light pulses across a set of i frequency values, wherein i≥2, the set of i frequency values including the first coherent light pulse having initial frequency ω1; scanning, simultaneously, a second coherent light pulse of the set of m coherent light pulses across a set of i correlated frequency values, the set of i correlated frequency values including the second coherent light pulse having initial frequency ω2, wherein each correlated frequency value is associated with a corresponding frequency value of the set of i frequency values as a correlated frequency grouping; and detecting the coherent output signal. Each correlated frequency value is selected so that the coherent output signal generated at each correlated frequency grouping equals the initial frequency ωoutput and the coherent output signal generated at each correlated frequency grouping equals the initial wavevector {right arrow over (k)}output.

公开(公告)号：US11486818B2

公开(公告)日：2022-11-01

申请号：US17329454

申请日：2021-05-25

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright

IPC: G01N21/31

Abstract: A method for coherent multidimensional spectroscopy may comprise illuminating a location in a sample with a set of m coherent light pulses, each coherent light pulse having an initial frequency ωm and an initial wave vector {right arrow over (k)}m, wherein m≥2, to generate a coherent output signal having an initial frequency ωoutput=Σ±ωm and an initial wavevector wave vector {right arrow over (k)}output=Σ±{right arrow over (k)}m; scanning a first coherent light pulse of the set of m coherent light pulses across a set of i frequency values, wherein i≥2, the set of i frequency values including the first coherent light pulse having initial frequency ω1; scanning, simultaneously, a second coherent light pulse of the set of m coherent light pulses across a set of i correlated frequency values, the set of i correlated frequency values including the second coherent light pulse having initial frequency ω2, wherein each correlated frequency value is associated with a corresponding frequency value of the set of i frequency values as a correlated frequency grouping; and detecting the coherent output signal. Each correlated frequency value is selected so that the coherent output signal generated at each correlated frequency grouping equals the initial frequency ωoutput and the coherent output signal generated at each correlated frequency grouping equals the initial wavevector {right arrow over (k)}output.

公开(公告)号：US20150092190A1

公开(公告)日：2015-04-02

申请号：US14499741

申请日：2014-09-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright ,  Erin Selene Boyle

IPC: G01N21/65 ,  G01J3/45

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: Methods of obtaining a multidimensional image of a sample are provided comprising (a) directing a first coherent light pulse having a first frequency ω1 and a first wave vector k1 at a first location in the sample, (b) directing a second coherent light pulse having a second frequency ω2 and a second wave vector k2 at the first location, (c) directing a third coherent light pulse having a third frequency ω3 and a third wave vector k3 at the first location and (d) detecting a coherent output signal having a fourth frequency ω4 and a fourth wave vector k4. At least two, but optionally all three, of the coherent light pulses each excite a different transition to a discrete quantum state (e.g., transitions to vibrational states or to electronic states) of a molecule or molecular functionality in the sample. Steps (a)-(d) are repeated at a sufficient number of other locations in the sample to provide the multidimensional image.

Abstract translation: 提供了获得样本的多维图像的方法，包括：（a）在样本中的第一位置处引导具有第一频率ω1和第一波矢量k1的第一相干光脉冲，（b）引导具有 在第一位置处的第二频率ω2和第二波矢量k2，（c）在第一位置处引导具有第三频率ω3和第三波矢量k3的第三相干光脉冲，以及（d）检测具有 第四频率ω4和第四波矢量k4。 每个相干光脉冲中的至少两个，但可选地，全部三个激发不同的跃迁到样品中分子或分子功能的离散量子态（例如，转变到振动状态或电子状态）。 在样本中的足够数量的其他位置重复步骤（a） - （d）以提供多维图像。

公开(公告)号：US20190391070A1

公开(公告)日：2019-12-26

申请号：US16446750

申请日：2019-06-20

Applicant: Wisconsin Alumni Research Foundation

Inventor： Darien James Morrow ,  Daniel David Kohler ,  John Curtis Wright

IPC: G01N21/25 ,  G01N21/63

Abstract: Methods for pump-probe spectroscopy are provided. In an embodiment, such a method comprises directing pump light having a frequency ωpump at a location in a sample to excite a transition between two quantum states of a target entity in the sample, directing probe light at the location to generate a coherent output signal having a frequency ωoutput and a wavevector koutput, and detecting the output signal as the probe light is scanned over a range of frequencies. In the method, either the transition excited by the pump light is a multiphoton transition corresponding to a frequency difference of n*ωpump, wherein n≥2; or the probe light is a set of m coherent light pulses, each coherent light pulse having a frequency ωm and a wavevector km, wherein m≥2; or both. Systems for carrying out the methods are also provided.

公开(公告)号：US09267893B2

公开(公告)日：2016-02-23

申请号：US14499741

申请日：2014-09-29

Applicant: Wisconsin Alumni Research Foundation

Inventor： John Curtis Wright ,  Erin Selene Boyle

IPC: G01J3/44 ,  G01N21/65 ,  G01J3/02

CPC classification number: G01N21/65 ,  G01J3/02 ,  G01J3/44 ,  G01N2201/06113 ,  G01N2201/0697

Abstract: Methods of obtaining a multidimensional image of a sample are provided comprising (a) directing a first coherent light pulse having a first frequency ω1 and a first wave vector k1 at a first location in the sample, (b) directing a second coherent light pulse having a second frequency ω2 and a second wave vector k2 at the first location, (c) directing a third coherent light pulse having a third frequency ω3 and a third wave vector k3 at the first location and (d) detecting a coherent output signal having a fourth frequency ω4 and a fourth wave vector k4. At least two, but optionally all three, of the coherent light pulses each excite a different transition to a discrete quantum state (e.g., transitions to vibrational states or to electronic states) of a molecule or molecular functionality in the sample. Steps (a)-(d) are repeated at a sufficient number of other locations in the sample to provide the multidimensional image.

Abstract translation: 提供了获得样本的多维图像的方法，包括：（a）在样本中的第一位置处引导具有第一频率ω1和第一波矢量k1的第一相干光脉冲，（b）引导具有 在第一位置处的第二频率ω2和第二波矢量k2，（c）在第一位置处引导具有第三频率ω3和第三波矢量k3的第三相干光脉冲，以及（d）检测具有 第四频率ω4和第四波矢量k4。 每个相干光脉冲中的至少两个，但可选地，全部三个激发不同的跃迁到样品中分子或分子功能的离散量子态（例如，转变到振动状态或电子状态）。 在样本中的足够数量的其他位置重复步骤（a） - （d）以提供多维图像。