公开(公告)号：US20240115762A1

公开(公告)日：2024-04-11

申请号：US18377791

申请日：2023-10-07

Applicant: Worcester Polytechnic Institute

Inventor： Jeannine Coburn ,  Melissa Wojnowski

IPC: A61L27/22 ,  A61L27/04 ,  A61L27/52

CPC classification number: A61L27/227 ,  A61L27/042 ,  A61L27/52 ,  A61L2400/06 ,  A61L2430/32

Abstract: Magneto-responsive properties are traditionally imparted to scaffold systems via integration of iron oxide-based magnetic nanoparticles (MNPs), yet poor understanding of long-term MNP toxicity presents a significant translational challenge. Given the demonstrated iron-binding capacity of silk fibroin (SF), passive chelation of ferric iron ions is explored herein as an alternative, MNP-free approach for magnetic functionalization of silk fibroin (SF)-based biomaterials. SF microfibers treated with aqueous ferric chloride (FeCl3) exhibit significantly increased iron content relative to the nascent protein.

公开(公告)号：US11110203B2

公开(公告)日：2021-09-07

申请号：US16548510

申请日：2019-08-22

Applicant: Worcester Polytechnic Institute

Inventor： Jeannine Coburn ,  Glenn Gaudette ,  Nhi Phan

IPC: C12N5/00 ,  A61L27/36

Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.

公开(公告)号：US20220054710A1

公开(公告)日：2022-02-24

申请号：US17465102

申请日：2021-09-02

Applicant: Worcester Polytechnic Institute

Inventor： Jeannine Coburn ,  Glenn Gaudette ,  Nhi Phan

IPC: A61L27/36 ,  C12N5/00

Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.

公开(公告)号：US20200061245A1

公开(公告)日：2020-02-27

申请号：US16548510

申请日：2019-08-22

Applicant: Worcester Polytechnic Institute

Inventor： Jeannine Coburn ,  Glenn Gaudette ,  Nhi Phan

IPC: A61L27/36 ,  C12N5/00

Abstract: Provided herein are enzymatically decellularized cells, and methods of producing said cells, that can be used in a scaffold. The scaffolds featured herein are biocompatible and can comprise decellularized cells that have been modified to express a bioactive agent or molecule.