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    CALIBRATION METHOD AND SYSTEM
    1.
    发明申请
    CALIBRATION METHOD AND SYSTEM 有权

    公开(公告)号：US20250057451A1

    公开(公告)日：2025-02-20

    申请号：US18712567

    申请日：2022-10-12

    Applicant: RSP SYSTEMS A/S

    Inventor： Signe Maria LUNDSGAARD-NIELSEN ,  Anders PORS ,  Anders WEBER

    IPC: A61B5/1495 ,  A61B5/145 ,  A61B5/1455 ,  G01N21/27 ,  G01N21/65

    Abstract: A system and method of calibrating a model used in a device for non-invasive in vivo measurement of an analyte concentration using Raman spectroscopy, the device including an optical source for providing an optical signal and an optical detector to receive a Raman scattered optical output, the method including: in response to the laser source being directed to a user's skin gathering Raman scattered radiation from the user's skin and based on that, calibrating the model based on reference data and the received Raman spectra over an extended period of days, such as 10 days or more.

    ANALYTE DETECTION APPARATUS AND METHOD OF DETECTING AN ANALYTE
    2.
    发明申请
    ANALYTE DETECTION APPARATUS AND METHOD OF DETECTING AN ANALYTE 有权

    公开(公告)号：US20230080810A1

    公开(公告)日：2023-03-16

    申请号：US17990139

    申请日：2022-11-18

    Applicant: RSP SYSTEMS A/S

    Inventor： Stefan Ovesen BANKE

    IPC: G01J3/44 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/12 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65 ,  A61B5/00 ,  G01J3/02

    Abstract: An analyte detection apparatus includes a radiation source for irradiating a sample and a receiver to receive an optical Raman spectrum of radiation transmitted back from the sample, the spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected. The receiver includes different types of analysis device each arranged to receive a selected part of the spectrum. The different types of analysis device include at least one analysis device having high resolution and/or high signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.

    OPTICAL PROBE FOR MEASURING LIGHT SIGNALS IN VIVO
    3.
    发明申请
    OPTICAL PROBE FOR MEASURING LIGHT SIGNALS IN VIVO 有权
    用于在体检中测量光信号的光学探头

    公开(公告)号：US20120044484A1

    公开(公告)日：2012-02-23

    申请号：US13255675

    申请日：2009-03-12

    Applicant: Morten Henneberg

    Inventor： Morten Henneberg

    IPC: G01J1/00

    CPC classification number: G02B21/0096 ,  A61B5/0059 ,  A61B5/0068 ,  A61B5/145 ,  A61B5/1455 ,  A61B5/1495 ,  A61B2562/0242 ,  G01N21/31 ,  G01N21/64 ,  G02B21/082

    Abstract: An optical probe for measuring light signals includes a first optical fiber guiding incoming light, a lens focusing incoming light towards a sample and collecting altered light from the sample, a second optical fiber guiding altered light, a light logging device measuring intensity fluctuations in the incoming light, wherein the light logging device is positioned after the first optical fiber, whereby the light logging device receives a part of the incoming light from the first fiber. The optical probe is normally applied for measuring light signals in vivo, and finds its primary applications within the field of optical spectroscopic measurements, where the light signals measured by said probe are applied in combination with an apparatus wherein light signals are analyzed against its spectral components for instance in Raman, fluorescence, phosphorescence absorption, diffusion and transmission studies. Embodiments of the present invention especially relates to and finds application within the area of Raman Spectroscopy.

    Abstract translation: 用于测量光信号的光学探针包括：引导入射光的第一光纤，将入射光聚焦到样品并收集来自样品的改变的光的透镜，引导改变的光的第二光纤;测光装置，测量入射光的强度波动 光，其中所述光测量装置位于所述第一光纤之后，由此所述光测量装置接收来自所述第一光纤的一部分入射光。 光探头通常用于体内测量光信号，并且在光谱测量领域中发现其主要应用，其中由所述探针测量的光信号与其中光信号针对其光谱分量分析的装置结合使用 例如在拉曼，荧光，磷光吸收，扩散和透射研究中。 本发明的实施例特别涉及并在拉曼光谱学领域中应用。

    Analyte detection apparatus and method of detecting an analyte
    4.
    发明授权
    Analyte detection apparatus and method of detecting an analyte 有权

    公开(公告)号：US12241784B2

    公开(公告)日：2025-03-04

    申请号：US17990139

    申请日：2022-11-18

    Applicant: RSP SYSTEMS A/S

    Inventor： Stefan Ovesen Banke

    IPC: G01J3/44 ,  A61B5/00 ,  A61B5/145 ,  A61B5/1455 ,  G01J3/02 ,  G01J3/12 ,  G01J3/18 ,  G01J3/28 ,  G01J3/36 ,  G01N21/65

    Abstract: An analyte detection apparatus includes a radiation source for irradiating a sample and a receiver to receive an optical Raman spectrum of radiation transmitted back from the sample, the spectrum including one or more parts of significance to an analyte to be detected and one or more parts not of significance to an analyte to be detected. The receiver includes different types of analysis device each arranged to receive a selected part of the spectrum. The different types of analysis device include at least one analysis device having high resolution and/or high signal to noise ratio for detecting a part of the spectrum of significance to the analyte to be detected and at least one second type of analysis device which provides lower resolution and/or lower signal-to-noise ratio, for detecting a part of the spectrum not of significance to the analyte to be detected.

    Method and apparatus for transdermal in vivo measurement by Raman spectroscopy
    5.
    发明授权
    Method and apparatus for transdermal in vivo measurement by Raman spectroscopy 有权

    公开(公告)号：US10674919B2

    公开(公告)日：2020-06-09

    申请号：US15508580

    申请日：2015-08-24

    Applicant: RSP SYSTEMS A/S

    Inventor： Stefan Ovesen Banke

    IPC: A61B5/00 ,  G01J3/44 ,  G01N21/65 ,  G01J3/02 ,  G01J1/42 ,  A61B5/1455 ,  A61B5/145

    Abstract: The use of a transdermal Raman spectrum to measure glucose or other substance concentration can give an inaccurate result if the Raman signals originate at a wrong skin depth. To predict whether a spectrum of Raman signals received transdermally in a confocal detector apparatus and having at least one component expected to have an intensity representing the concentration of glucose or another skin component at a point of origin of the Raman signals below the surface of the skin will accurately represent the concentration, peaks in the spectrum at 883/4 cm−1 and 894 cm−1 are measured to determine whether the Raman signals originate primarily within the stratum corneum so that the spectrum will be less likely to represent the concentration accurately or originate primarily below the stratum corneum so that the spectrum will be more likely to represent the concentration accurately.

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