公开(公告)号：US12246091B2

公开(公告)日：2025-03-11

申请号：US17268003

申请日：2019-04-29

Applicant: ABNOBA GMBH

Inventor： Gero Leneweit ,  Bárbara Santos De Miranda

IPC: A61K9/127 ,  A61K9/1277 ,  A61K31/10 ,  A61K38/16 ,  A61K47/06 ,  A61K47/24 ,  A61K47/42 ,  B01F23/41 ,  B01F23/43 ,  B01F29/15 ,  B01F101/22 ,  B01J13/08

Abstract: A method for encapsulating active ingredients in liposomes having an active ingredient solution encapsulated with a bilayer composed of two monomolecular layers of amphiphilic compounds comprises: (a) providing the active ingredient solution; (b) providing an emulsion by emulsifying the active ingredient solution in a first liquid in the presence of the amphiphilic compound; (c) providing a liquid phase; (d) contacting the emulsion with the liquid phase to form a phase boundary; and (e) centrifuging the emulsion and the liquid phase that are in contact with one another via the phase boundary, wherein, on passage of the phase boundary, the amphiphilic compound enriched there is added onto the monomolecular inner layer to form a monomolecular outer layer, in order to create the bilayer. The first liquid of the emulsion is chosen such that the solubility of the amphiphilic compound in the first liquid is not more than 1×10−4 mol/l.

公开(公告)号：US12018111B2

公开(公告)日：2024-06-25

申请号：US17694883

申请日：2022-03-15

Applicant: POSTECH Research and Business Development Foundation

Inventor： Jin Kon Kim ,  Seonghyeon Ahn

IPC: C08F293/00 ,  A61K9/107 ,  B01J13/08 ,  B01J31/06 ,  B01J35/23 ,  B01J37/00 ,  B01J37/04 ,  C08J5/18

CPC classification number: C08F293/00 ,  A61K9/1075 ,  B01J13/08 ,  B01J31/063 ,  B01J35/23 ,  B01J37/0072 ,  B01J37/04 ,  C08J5/18 ,  B01J2231/005 ,  C08J2353/02

Abstract: Proposed are a core-satellite micelle containing a tetra-block copolymer and a preparation method thereof. The core-satellite micelle includes a core, a shell surrounding the core, and a plurality of satellite domains positioned inside the shell. The core-satellite micelle contains a tetra-block copolymer represented by Structural Formula 1 below. The shell includes a first-monomer first block A1 and a first-monomer second block A2, and the satellite domain includes a second-monomer first block B1 and a second-monomer second block B2. The core-satellite micelle is foiled through self-assembly of the tetra-block copolymer, thereby having a larger interfacial contact area than existing block-copolymer micelles. Therefore, the core-satellite micelle can be used in next-generation nanotechnology applications such as drug delivery systems, porous catalyst materials, and sensors.

A1-B1-A2-B2  [Structural Formula 1]

In Structural Formula 1,



A1 is a first-monomer first block,
B1 is a second-monomer first block,
A2 is a first-monomer second block, and
B2 is a second-monomer second block.

公开(公告)号：US20240050912A1

公开(公告)日：2024-02-15

申请号：US17766387

申请日：2020-09-30

Applicant: The Regents of the University of Colorado, a body corporate

Inventor： Mark A. Borden ,  Gazendra Shakya ,  Xiaoyun Ding

IPC: B01J13/00 ,  B01J13/08 ,  C09K5/04

CPC classification number: B01J13/0021 ,  B01J13/08 ,  C09K5/048

Abstract: The inventive technology is directed to droplet compositions having novel endoskeletal and/or exoskeletal shell architectures configured to produce enhanced vaporization characteristics.

公开(公告)号：US11850851B2

公开(公告)日：2023-12-26

申请号：US17545304

申请日：2021-12-08

Applicant: IamFluidics Holding B.V.

Inventor： Claas Willem Visser ,  Tom Kamperman ,  Hermanus Bernardus Johannes Karperien ,  Detlef Lohse

IPC: B41J2/21 ,  B41J2/14 ,  B01J13/08 ,  B01J13/14

CPC classification number: B41J2/14 ,  B01J13/08 ,  B01J13/14 ,  B41J2/211

Abstract: A production process and a related device comprises a formation process comprising: contacting a first liquid material and a second liquid material with each other at a contact point in a gas atmosphere, wherein at the contact point at least one of the first liquid material and the second liquid material is provided as a liquid jet propagating in a direction, to provide at the contact point a third jet of a coalesced third material propagating in a third direction.

公开(公告)号：US20230390167A1

公开(公告)日：2023-12-07

申请号：US18033087

申请日：2021-10-29

Applicant: BASF SE

Inventor： Bernd Dieter OSCHMANN ,  Wolfgang KRAUSE ,  Michael GOLLNER

IPC: A61K8/11 ,  A61Q13/00 ,  A61K8/85 ,  B01J13/08 ,  C11D3/50

CPC classification number: A61K8/11 ,  A61Q13/00 ,  A61K8/85 ,  B01J13/08 ,  C11D3/505 ,  A61K2800/412 ,  A61K2800/22

Abstract: The present invention relates to a process for producing polymer microparticles laden with at least one aroma chemical, which comprises i. dissolving the at least one aroma chemical and an organic polymer composition, which contains at least one polyester as a main constituent, in a volatile organic solvent having a boiling point lower than the boiling point of the aroma chemical and having a solubility in water of at most 100 g/L at 20° C. and 1013 mbar, whereby a solution of the aroma chemical and the organic polymer composition is obtained; ii. emulsifying the solution obtained in step i. in an aqueous medium containing at least one dispersant; iii. removing the volatile organic solvent from the emulsion by evaporation at a temperature of below 80° C. and at a pressure below atmospheric pressure, whereby an aqueous suspension of the laden polymer microparticles is obtained. The present invention also relates to microparticles laden with an aroma chemical, obtainable by the process described herein and to products containing the microparticle composition. The compositions are useful as additives for imparting a scent or flavour to a product. The compositions allow for controlled release of the aroma chemicals.

公开(公告)号：US20230330234A1

公开(公告)日：2023-10-19

申请号：US17796671

申请日：2021-02-01

Applicant: FREIE UNIVERSITÄT BERLIN

Inventor： Rainer HAAG ,  Magda FERRARO ,  Ehsan MOHAMMADIFAR ,  Michael SCHIRNER

IPC: A61K47/34 ,  A61K9/107 ,  A61K31/404 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4545 ,  A61K9/19 ,  B01J13/08

CPC classification number: A61K47/34 ,  A61K9/1075 ,  A61K31/404 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4545 ,  A61K9/19 ,  B01J13/08

Abstract: It is provided a composition comprising a hyperbranched polyester polyol derivative and a small molecule comprising at least one cyclic amine. The hyperbranched polyester polyol derivative is obtainable by a method comprising the following steps: a) reacting only glycidol and ε-caprolactone at a temperature lying in a range of between 40° C. and 140° C. to obtain a hyperbranched polyester polyol derivative in which caprolactone residues and glycerol residues are randomly arranged; b) reacting the hyperbranched polyester polyol derivative of step a) with a sulfation reagent to obtain a sulfated hyperbranched polyester polyol as hyperbranched polyester polyol derivative.

公开(公告)号：US20230303778A1

公开(公告)日：2023-09-28

申请号：US18205122

申请日：2023-06-02

Applicant: ETH ZURICH

Inventor： Jean-Christophe Leroux ,  Simon Matoori ,  Olha Voznyuk Wuerthinger

IPC: C08G81/02 ,  B01J13/08 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  G01N33/84 ,  G01N33/68 ,  B01J13/12 ,  C09K11/06

CPC classification number: C08G81/025 ,  B01J13/08 ,  C08K5/19 ,  C08K5/353 ,  C08K5/42 ,  G01N33/84 ,  G01N33/689 ,  B01J13/12 ,  C09K11/06 ,  G01N2800/085 ,  A61K9/1273

Abstract: The present invention provides polymersomes comprising amphiphilic block-copolymers and their use to quantify ammonia in samples (e.g., body fluid samples). More particularly, it provides a polymersome comprising (a) a membrane, which comprises a block copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is higher than 1.0 and lower than 4.0; and (b) a core which encloses an acid and at least one pH-sensitive dye. Compositions, strips and kits comprising the polymersomes are also provided along with methods of quantifying ammonia in a sample using the polymersomes, compositions and kit.

公开(公告)号：US20230079081A1

公开(公告)日：2023-03-16

申请号：US17986178

申请日：2022-11-14

Applicant: South China University of Technology ,  SOUTH CHINA UNIVERSITY OF TECHNOLOGY-ZHUHAI INSTITUTE OF MODERN INDUSTRIAL INNOVATION

Inventor： QIANG HUANG ,  Qing Gao ,  Bin Zhang ,  Xiong Fu

IPC: B01J13/08 ,  B01J13/20 ,  C11B9/00 ,  C08B30/04 ,  A23L27/00

Abstract: Disclosed in the present invention are a starch-embedded aroma substance microcapsule and a preparation method therefor. The method comprises: performing degreasing treatment on starch, gelatinizing the starch at high temperature, sequentially adding aroma substances having different molecular sizes into the starch paste, and compounding at high temperature; and finally, cooling, centrifuging, washing, and drying to obtain an aroma substance microcapsule. The total embedding rate of the aroma substances in the obtained microcapsule can reach 46.64%. The present invention is simple and convenient in process, and easy in condition control, does not need large special equipment, and has low cost and high efficiency.

公开(公告)号：US20230008121A1

公开(公告)日：2023-01-12

申请号：US17782368

申请日：2020-12-04

Applicant: SIGILON THERAPEUTICS, INC.

Inventor： Michael Beauregard ,  Faith C. David-Hegerich ,  John Patrick Golden ,  Joseph Gordon ,  Erika Ellen Johnston ,  Robert James Miller ,  Justin David Morse ,  Peter Calvin Costello

IPC: G01N1/31 ,  B01D43/00 ,  B01J2/04 ,  B01J13/08

Abstract: Described herein are apparatuses and methods for conditioning particles. In some embodiments, the apparatuses and methods are configured for first-in-first-out transit of particles through a chamber containing a conditioning fluid.

公开(公告)号：US20220390440A1

公开(公告)日：2022-12-08

申请号：US17724894

申请日：2022-04-20

Applicant: The University of Massachusetts

Inventor： Matthew A. Holden ,  Max J. Lein ,  Arash Manafirad ,  Dan Ezra Aurian-Blajeni

IPC: G01N33/543 ,  G01N33/68 ,  B01J13/08

Abstract: Droplet-interface bilayer and lipid bilayer membrane compositions stabilized with an amphiphilic polymer are disclosed. Methods of making and using the compositions are also disclosed.