公开(公告)号：US20250100905A1

公开(公告)日：2025-03-27

申请号：US18971454

申请日：2024-12-06

Applicant: Emerging Compounds Treatment Technologies, Inc.

Inventor： Michael G. Nickelsen ,  Steven E. Woodard ,  John C. Berry

IPC: C02F1/42 ,  B01D1/00 ,  B01D3/00 ,  B01J41/05 ,  B01J41/12 ,  B01J49/57 ,  B01L1/00 ,  B01L3/00 ,  C02F101/36

Abstract: A sustainable system for removing and concentrating per- and polyfluoroalkyl substances (PFAS) from water. The system includes an anion exchange vessel having a selected anion exchange resin therein configured to remove PFAS from the water. A line coupled to the vessel introduces a flow of water contaminated with PFAS such that the PFAS bind to the selected anion exchange resin and are thereby removed from the water. A regenerant solution line is coupled to the anion exchange vessel to introduce an optimized regenerant solution to the anion exchange vessel to remove the PFAS from the anion exchange resin, thereby regenerating the anion exchange resin and generating a spent regenerant solution comprised of the removed PFAS and the optimized regenerant solution. A separation and recovery subsystem recovers the optimized regenerant solution for reuse and separates and concentrates the removed PFAS.

公开(公告)号：US12163160B2

公开(公告)日：2024-12-10

申请号：US18333718

申请日：2023-06-13

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  B01D15/08 ,  B01D15/16 ,  B01D15/36 ,  B01D15/38 ,  B01J20/281 ,  B01J41/05 ,  B01J41/13 ,  B01J41/20 ,  B01J47/022 ,  C12N7/00 ,  C12N15/86 ,  C12N15/864 ,  G01N21/33

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US20240317952A1

公开(公告)日：2024-09-26

申请号：US18611853

申请日：2024-03-21

Applicant: HYDROLITE LTD

Inventor： Charly David AZRA ,  Yauhen AKAYEU ,  Amiram SISSO

IPC: C08J5/22 ,  B01D67/00 ,  B01D69/02 ,  B01D71/26 ,  B01D71/28 ,  B01D71/78 ,  B01J41/05 ,  B01J41/14 ,  B01J47/12 ,  C02F1/46 ,  C08J3/00 ,  C08J3/24 ,  C08J7/12 ,  C25B13/08 ,  H01M8/0221

CPC classification number: C08J5/2287 ,  B01D67/0006 ,  B01D69/02 ,  B01D71/26 ,  B01D71/281 ,  B01D71/78 ,  B01J41/05 ,  B01J41/14 ,  B01J47/12 ,  C02F1/4604 ,  C08J3/005 ,  C08J3/24 ,  C08J7/123 ,  C25B13/08 ,  H01M8/0221 ,  B01D2323/081 ,  B01D2323/30 ,  B01D2323/385 ,  B01D2323/60 ,  B01D2325/42 ,  C08J2323/06 ,  C08J2327/04 ,  C08J2353/02 ,  C08J2423/06 ,  C08J2427/04 ,  C08J2453/02

Abstract: Methods of preparing reinforced anion exchange membranes are provided, as well as produced membranes and corresponding devices utilizing the membranes. Methods comprise compounding a halide-functionalized polymer (selected to react with amines to yield anion-conducting quaternary amine groups) with thermoplastic polymer(s) (selected to support and/or reinforce the membrane), and with copolymer(s) (selected to enhance the compounding of the polymers)—by heating, mixing and cooling—to form blend pellets, extruding the blend pellets to form a blend film, cross-linking polymer(s), and functionalizing the blend film to prepare the anion exchange membrane. Functionalization comprises a quaternization step comprising reacting halogen groups of the first polymer with tertiary amines to produce the quaternary amine groups with ion-exchange functionality. Reinforced anion exchange membranes are provided, which are produced by the disclosed methods, functionalized to yield a membrane for fuel cell(s), electrolyzer(s), reversible electrochemical device(s), desalination unit(s), etc.

公开(公告)号：US20240123437A1

公开(公告)日：2024-04-18

申请号：US18269974

申请日：2021-12-31

Applicant: Technion Research & Development Foundation Limited

Inventor： Charles Eliezer DIESENDRUCK ,  Dario R. DEKEL

IPC: B01J41/14 ,  B01J41/05 ,  B01J47/12 ,  C07D209/44 ,  C08F212/08 ,  C08J5/22 ,  H01M8/083 ,  H01M8/103

CPC classification number: B01J41/14 ,  B01J41/05 ,  B01J47/12 ,  C07D209/44 ,  C08F212/08 ,  C08J5/2231 ,  C08J5/2243 ,  H01M8/083 ,  H01M8/103 ,  C08F2800/10 ,  C08J2323/06 ,  C08J2325/08 ,  H01M2008/1095

Abstract: Polymeric ion conductors composed of a polymeric matrix associated with an isoindolinium moiety represented by Formula I as described in the specification are provided. Anion conducting compositions comprising an anion conducting polymer associated with, or threaded within and having mechanically interlocked therearound, a cyclic moiety are also provided. lonomeric materials, including, for example, ion exchange membranes such as anion exchange membranes, made of the polymeric ion conductor and/or the anion conducting composition, and electrochemical systems and articles-of-manufacturing containing the polymeric ion conductor, the anion conducting composition or the ion exchange membrane are also provided.

公开(公告)号：US11938464B2

公开(公告)日：2024-03-26

申请号：US18147894

申请日：2022-12-29

Applicant: JCR Pharmaceuticals Co., Ltd.

Inventor： Tomoki Fukatsu ,  Chika Morooka

IPC: B01D15/18 ,  B01D15/30 ,  B01D15/36 ,  B01J20/283 ,  B01J20/285 ,  B01J20/286 ,  B01J20/32 ,  B01J41/05 ,  B01J41/07 ,  B01J41/14 ,  B01J41/20 ,  C07K16/00 ,  G01N30/06 ,  G01N30/34 ,  G01N30/46 ,  G01N30/74 ,  G01N30/88

CPC classification number: B01J20/283 ,  B01D15/1871 ,  B01D15/305 ,  B01D15/363 ,  B01J20/285 ,  B01J20/286 ,  B01J20/3219 ,  B01J20/3248 ,  B01J41/05 ,  B01J41/07 ,  B01J41/14 ,  B01J41/20 ,  G01N30/06 ,  G01N30/34 ,  G01N30/46 ,  G01N30/461 ,  G01N30/74 ,  G01N30/88 ,  C07K16/00 ,  G01N2030/067 ,  G01N2030/8836

Abstract: A chromatography column for the use of separation of acidic sugar chains, wherein the column comprises a first column and a second column, the second column connected by a flow path downstream of an outlet of the first column, and selected from the following (1) or (2): (1) the carrier of the first column is hydrophobically modified silica having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine; (2) the carrier of the first column is a resin having a group containing a primary amine, a secondary amine or/and a tertiary amine, and the carrier of the second column is hydrophobically modified silica having a group containing a primary amine, a secondary amine, or/and a tertiary amine.

公开(公告)号：US11532406B2

公开(公告)日：2022-12-20

申请号：US16095865

申请日：2017-04-24

Applicant: Mayo Foundation for Medical Education and Research

Inventor： Timothy R. DeGrado ,  Huailei Jiang

IPC: A61K51/02 ,  C01B35/06 ,  G21G4/08 ,  B01J41/05

Abstract: Embodiments of the invention provide methods of synthesizing 18F-tetrafluoroborate (18F-TFB) via direct radiofluorination on boron trifluoride (BF3) to enhance both labeling yield and specific activity. Uses of 18F-TFB are also contemplated.

公开(公告)号：US20220250948A1

公开(公告)日：2022-08-11

申请号：US17666870

申请日：2022-02-08

Applicant: Emerging Compounds Treatment Technologies, Inc.

Inventor： Steven E. Woodard ,  John C. Berry ,  Michael G. Nickelsen

IPC: C02F1/42 ,  B01J41/05 ,  B01J49/07

Abstract: A system for removing long-chain and short-chain per- and polyfluoroalkyl substances (PFAS) from contaminated water using a regenerable anion exchange resin includes at least one first anion exchange resin vessel configured to receive a flow of water contaminated with long and short-chain PFAS compounds. The at least one first anion exchange resin vessel includes a first regenerable anion exchange resin therein having a high affinity for long-chain PFAS compounds configured such that a majority of the long-chain PFAS compounds sorb to the first regenerable anion exchange resin to remove a majority of the long-chain PFAS compounds from the contaminated water and produce a flow of water having a majority of the long-chain PFAS compounds removed. The system also includes at least one second anion exchange resin vessel configured to receive the flow of water having a majority of the long-chain PFAS compounds removed. The at least one second anion exchange resin vessel includes a second regenerable anion exchange resin therein having a high affinity for short-chain PFAS compounds and is configured such that a majority of the short-chain PFAS compounds sorb to the second anion exchange resin to remove a majority of the short-chain PFAS compounds from the contaminated water and produce a treated flow of water having a majority of the long and short-chain PFAS compounds removed.

公开(公告)号：US11098286B2

公开(公告)日：2021-08-24

申请号：US16060405

申请日：2016-12-09

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  C12N15/86 ,  B01D15/38 ,  B01J20/281 ,  C12N15/864 ,  G01N21/33 ,  B01J41/05 ,  B01D15/16 ,  B01D15/36 ,  B01J41/20

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US11028372B2

公开(公告)日：2021-06-08

申请号：US16060404

申请日：2016-12-09

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  C12N7/00 ,  B01D15/38 ,  B01J20/281 ,  C12N15/864 ,  G01N21/33 ,  B01J41/05 ,  B01D15/16 ,  B01D15/36 ,  B01J41/20

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.

公开(公告)号：US11015173B2

公开(公告)日：2021-05-25

申请号：US16060406

申请日：2016-12-09

Applicant: The Trustees of the University of Pennsylvania

Inventor： Martin Lock ,  Mauricio Alvira

IPC: C12N7/02 ,  B01J20/281 ,  B01D15/08 ,  C12N7/00 ,  B01J41/13 ,  C12N15/86 ,  B01J47/022 ,  B01D15/38 ,  C12N15/864 ,  G01N21/33 ,  B01J41/05 ,  B01D15/16 ,  B01D15/36 ,  B01J41/20

Abstract: A two-step chromatography purification scheme is described which selectively captures and isolates the genome-containing rAAV vector particles from the clarified, concentrated supernatant of a rAAV production cell culture. The process utilizes an affinity capture method performed at a high salt concentration followed by an anion exchange resin method performed at high pH to provide rAAV vector particles which are substantially free of rAAV intermediates.