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公开(公告)号：US12298247B2
公开(公告)日：2025-05-13
申请号：US17772085
申请日：2020-10-27
Inventor： Lois Smith , Bertan D. Cakir , John Padraic Romfh , Peili Chen , Daryoosh Vakhshoori
Abstract: Apparatuses and methods for using Raman Resonance Spectroscopy to evaluate metabolic and oxygenation status of the eye are disclosed herein. In some embodiments, metabolic mapping of the eye may be performed by aligning a Raman spectrum and a recorded spatial image of the eye.
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公开(公告)号：US12298182B2
公开(公告)日：2025-05-13
申请号：US18600698
申请日：2024-03-09
Applicant: NOVA LTD.
Inventor： Gilad Barak , Yonatan Oren
Abstract: A polarized Raman Spectrometric system for defining parameters of a polycrystalline material, the system comprises a polarized Raman Spectrometric apparatus, a computer-controlled sample stage for positioning a sample at different locations, and a computer comprising a processor and an associated memory. The polarized Raman Spectrometric apparatus generates signal(s) from either small sized spots at multiple locations on a sample or from an elongated line-shaped points on the sample, and the processor analyzes the signal(s) to define the parameters of said polycrystalline material.
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公开(公告)号：US20250143608A1
公开(公告)日：2025-05-08
申请号：US18581287
申请日：2024-02-19
Applicant: WALLETMED LIMITED
Inventor： Jakub Buszynski , Michal Gasior , Andrzej Miturski , Wojciech Paprota
IPC: A61B5/1459 , A61B5/00 , A61B5/145 , G01J3/28 , G01J3/44
Abstract: Embodiments of the present disclosure may include an implantable device (100) for in vivo measurement of metabolites, including a laser diode (110) or an IR diode (120) or optical waveguide as an external (outside body) light source with a laser diode (110) or an IR diode (120) for Raman spectroscopy unit (140). Embodiments may also include an optical filter (130) that filters the scattered light. Embodiments may also include a Raman spectroscopy unit (140) for detecting the metabolic profile of a subject. Embodiments may also include a Fabry-Pérot interferometer (150) with a spherical mirror, functioning as an etalon, for refining the detection of Raman scattering signals. Embodiments may also include a CMOS sensor (160) for capturing the refined Raman scattering signals. Embodiments may also include a piezo element (170a) or MEMS actuator (170b) for actuating the Fabry-Pérot interferometer (150). Embodiments may also include MCU (180) as a controller and a processing unit.
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公开(公告)号：US12287291B1
公开(公告)日：2025-04-29
申请号：US18930957
申请日：2024-10-29
Applicant: Apollon Inc.
Inventor： Miyeon Jue , Young Kyu Kim , Aram Hong
Abstract: A compact Raman spectroscopic analysis device includes a housing that forms an internal accommodation space therein, a light source unit that is disposed within the housing and irradiates light onto a subject, a light receiving unit that is disposed within the housing and receives light reflected or scattered from the subject to obtain a Raman spectrum, and a processor that is disposed within the housing and configured to analyze biological material of the subject based on a peak area value of a Raman spectrum range corresponding to the biological material. The light receiving unit includes a diffraction grating that reflects the reflected or scattered light, a slit through which the reflected light passes, and a light detector.
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公开(公告)号：US20250130172A1
公开(公告)日：2025-04-24
申请号：US18936790
申请日：2024-11-04
Applicant: NOVA LTD.
Inventor： Elad Schleifer , Yonatan Oren , Amir Shayari , Eyal Hollander , Valery Deich , Shimon YALOV , Gilad Barak
Abstract: An optical measurement system, which include an illumination path that is configured to illuminate an illuminated area of a sample; a collection path configured to collect illumination emitted from the illuminated area as a result of the illumination of the illuminated area; a spatial filter that is tunable; a Raman detector; and wherein the spatial filter is positioned upstream to the Raman detector, and is configured to spatially filter the illumination emitted from the illuminated area to provide spatially filtered illumination. The Raman detector is configured to receive the spatially filtered illumination and to generate one or more Raman spectra.
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Patent Agency Ranking
公开(公告)号：US20250127437A1
公开(公告)日：2025-04-24
申请号：US18833762
申请日：2023-01-26
Applicant: ATONARP INC.
Inventor： Akihiko NAKAJIMA
IPC: A61B5/1455 , A61B5/00 , G01J3/44
Abstract: A system for measuring a concentration of a component included in a body fluid includes: an apparatus that acquires data including spectra in a time series obtained by irradiating at least part of the body fluid in a flowing state with laser light; and an analyzer apparatus that analyzes analysis target spectrum included in the acquired data based on an analysis reference spectrum that is highly similar to the analysis target spectrum, out of a plurality of reference spectra that primarily reflect one out of a plurality of principal components of the body fluid, and determines the concentration of a target component in the body fluid.
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公开(公告)号：US12281942B2
公开(公告)日：2025-04-22
申请号：US18319615
申请日：2023-05-18
Applicant: Wayne State University
Inventor： Gregory William Auner , Michelle Ann Brusatori , Changhe Huang
Abstract: Apparatuses, systems, and methods for Raman spectroscopy are described. In certain implementations, a spectrometer is provided. The spectrometer may include a plurality of optical elements, comprising an entrance aperture, a collimating element, a volume phase holographic grating, a focusing element, and a detector array. The plurality of optical elements are configured to transfer the light beam from the entrance aperture to the detector array with a high transfer efficiency over a preselected spectral band.
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公开(公告)号：US12281941B2
公开(公告)日：2025-04-22
申请号：US17723817
申请日：2022-04-19
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Enrico Gratton , Alexander Dvornikov
Abstract: An imaging system comprises an excitation light source, a directing element positioned to direct light from the excitation light source toward a sample, a detector configured to measure incoming light from the sample, a filter cavity positioned between the sample and the detector, a first filter configured to be inserted into the filter cavity, a sine filter configured to be inserted into the filter cavity, and a processing unit communicatively connected to the detector, configured to receive image data from the detector to form an image. Methods of constructing a hyperspectral image of a sample are also described.
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公开(公告)号：US20250123147A1
公开(公告)日：2025-04-17
申请号：US18988259
申请日：2024-12-19
Applicant: The General Hospital Corporation
Inventor： Seok-Hyun Yun , Amira Eltony , Desmond Chow Ming Chia
Abstract: Systems and methods are provided for analyzing a biomechanical property of a medium using stimulated Brillouin scattering microscopy. The method can include a first step of applying a probe beam and pulsed pump beam to a target section of the medium, wherein the pump beam interacts with the probe beam to generate at least one acoustic wave in the medium and at least one Brillouin signal is produced as a result of the generated acoustic wave. The method can also include a second step of receiving the produced Brillouin signal and a third step of determining, using a processor and the Brillouin signal, information associated with at least one biomechanical property of the target section.
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公开(公告)号：US20250109988A1
公开(公告)日：2025-04-03
申请号：US18905494
申请日：2024-10-03
Applicant: Thorlabs, Inc.
Inventor： Matthew Singer , Ryan Joseph Priore , Longfei Ye , Erik Baigar
Abstract: A method for fabrication of a chip for surface enhanced Raman spectroscopy (SERS), including: providing a substrate; texturing a surface of the substrate to form a plurality of pillars randomly on the surface until a desired average pillar height, average pillar width and/or pillar density is/are reached; depositing a metal onto the surface of the textured substrate; and thermally annealing the metal such that the metal forms a layer encasing the pillars.
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