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    MEASURING IONS WITH CHARGE REDUCTION
    1.
    发明申请
    MEASURING IONS WITH CHARGE REDUCTION 有权

    公开(公告)号：US20250164443A1

    公开(公告)日：2025-05-22

    申请号：US18841235

    申请日：2023-02-24

    Applicant: Micromass UK Limited

    Inventor： Jakub Ujma ,  Kevin Giles

    IPC: G01N27/623 ,  H01J49/00

    Abstract: Disclosed are methods of mass spectrometry that use charge reduction techniques to reduce the average charge of the ions to increase the mass to charge ratio spacings between different charge states for the ion species prior to mass analysis. In embodiments there is disclosed a method for determining a collision cross section for an ion species, wherein an ion mobility is determined for an ion species in a first state without charge reduction and the mass to charge ratios for the ion species are then measured in a second, charge-reduced state. The average charge determined for the ion species in the first state is then used together with the average mass determined from the ion species in the second state and the ion mobility determined for the ion species in the first state to determine a collision cross section for the ion species in the first state.

    ABLATION DEVICE
    2.
    发明申请
    ABLATION DEVICE 有权

    公开(公告)号：US20250157807A1

    公开(公告)日：2025-05-15

    申请号：US18920553

    申请日：2024-10-18

    Applicant: GEOMAR Helmholtz Centre for Ocean Research Kiel

    Inventor： Jan FIETZKE

    IPC: H01J49/04 ,  H01J49/00 ,  H01J49/10 ,  H01J49/24

    Abstract: An arrangement for analyzing solids includes a laser ablation chamber, a gas flow vacuum pump, and cell and mixed gas feeds. The pump has a first sample gas tube, second mixed gas tube, nozzle, and expansion chamber. The pump is downstream of the ablation chamber. The first tube starts from the ablation chamber. The first tube terminates at the nozzle at the transition to the expansion chamber. The second tube terminates at the expansion chamber. The ablation chamber is operated at a negative pressure. In the ablation chamber, a primary ablation plasma is formed from a sample and condensed to form an aerosol and, together with the cell gas, form the sample gas. Due to the flow of the mixed gas in the second tube, the pump also carries along sample gas in the first tube. The sample and mixed gases are combined in the expansion chamber before analysis.

    MULTI-MODE IONIZATION APPARATUS AND USES THEREOF
    3.
    发明申请
    MULTI-MODE IONIZATION APPARATUS AND USES THEREOF 有权

    公开(公告)号：US20250157805A1

    公开(公告)日：2025-05-15

    申请号：US19018656

    申请日：2025-01-13

    Applicant: MSTM, LLC

    Inventor： Milan Pophristic

    IPC: H01J49/04 ,  G01N27/623 ,  H01J49/00 ,  H01J49/06 ,  H01J49/16 ,  H01J49/24

    Abstract: An ionizing system includes a flange device for connection to a mass spectrometer or ion mobility spectrometer having the property of providing a barrier between the lower pressure region of the spectrometer and a higher pressure region substantially at atmospheric pressure, and a channel therethrough providing fluid communication between the higher and lower pressure regions. A plate device independent of the flange device which can accommodate multiple samples, such as a sample plate device, when placed over the channel in the flange device substantially seals the channel. Sliding the sample plate device while in intimate contact with the flange device provides a means to sequentially and rapidly expose said samples to the opening of the channel and thus the lower pressure region. Samples are ionized when exposed to the lower pressure region in as little as one sample per second using multiple ionization methods.

    COMPOUND IDENTIFICATION USING A MASS SPECTRUM
    4.
    发明申请
    COMPOUND IDENTIFICATION USING A MASS SPECTRUM 有权

    公开(公告)号：US20250157589A1

    公开(公告)日：2025-05-15

    申请号：US18835672

    申请日：2023-02-02

    Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

    Inventor： David Michael Cox ,  Gordana Ivosev

    IPC: G16C20/20 ,  H01J49/00

    Abstract: A measured mass spectrum and intensity data provided as a function of m/z and at least one additional dimension are received. Peaks of the measured spectrum are compared to peaks of each of a plurality of library mass spectra. A set of library mass spectra is identified using a fit score. For each spectrum of the set, a group of related peaks of the measured spectrum calculated using a deconvolution algorithm is recalculated. The recalculation lowers a threshold for selection in the group if a matching peak of the library spectrum contributed to the fit score. A group of related peaks of the measured spectrum is produced for each library spectrum. For each spectrum of the set, peaks of the group are compared to peaks of the library spectrum and a purity score is calculated. At least one library spectrum of the set with the highest purity score is identified.

    Physical-chemical property scoring for structure elucidation in ion spectrometry
    5.
    发明授权
    Physical-chemical property scoring for structure elucidation in ion spectrometry 有权

    公开(公告)号：US12293907B2

    公开(公告)日：2025-05-06

    申请号：US17688470

    申请日：2022-03-07

    Applicant: Bruker Scientific LLC

    Inventor： Rohan Thakur ,  Robin Park

    IPC: H01J49/00 ,  G01N33/68 ,  G16C20/20

    Abstract: Disclosed is a method of associating molecular structures with signal peaks in spectrometry data obtained from separation according to one or more physical-chemical properties, comprising, as the case may be repeatedly: providing one or more signal peaks in acquired spectrometry data being related to an experimental value of mobility or a related property; ascertaining one or more molecular structure candidates suitable for being associated with the one or more signal peaks; providing by one of calculating, estimating, deriving and deducing for each molecular structure candidate a distribution of first match scores as a function of mobility; defining a presumed first match score for each molecular structure candidate as output from the respective distribution on applying the experimental value of mobility of the one or more signal peaks; and using the presumed first match score in a step of associating a molecular structure with the one or more signal peaks.

    Preventing Errors in Processing and Interpreting Mass Spectrometry Results
    9.
    发明申请
    Preventing Errors in Processing and Interpreting Mass Spectrometry Results 有权

    公开(公告)号：US20250125133A1

    公开(公告)日：2025-04-17

    申请号：US18420683

    申请日：2022-07-05

    Applicant: DH Technologies Development Pte. Ltd.

    Inventor： David Michael Cox ,  Lyle Lorrence Burton

    IPC: H01J49/00 ,  G01N30/86

    Abstract: An analytical instrument produces intensity versus time measurements or intensity versus m/z measurements for each acquisition of n acquisitions using m instrument parameter values for each acquisition of n acquisitions, wherein n is a number greater than or equal to two and m is a number equal to or greater than one. For each acquisition of the n acquisitions, the instrument stores a data file that includes m one or more instrument parameter values applied to the instrument, producing n data files. A first data file of the n data files for a first acquisition is retrieved. A next data file of the n data files of a next acquisition is retrieved. The m corresponding parameter values of the first data file and the next data file are compared. If any corresponding parameter values differ between the first data file and the next data file, a notification of an instrument parameter difference corresponding to a name of the next data file is displayed.

    Bench-top time of flight mass spectrometer
    10.
    发明授权
    Bench-top time of flight mass spectrometer 有权

    公开(公告)号：US12278097B2

    公开(公告)日：2025-04-15

    申请号：US18650681

    申请日：2024-04-30

    Applicant: Micromass UK Limited

    Inventor： Ruth Wamsley ,  William Johnson ,  Peter Spreadbury ,  Paul Doorbar ,  Michael Wilson

    IPC: H01J49/00 ,  H01J49/06 ,  H01J49/24 ,  H01J49/40

    Abstract: A start-up routine for a mass spectrometer is performed automatically upon switching ON the mass spectrometer. The mass spectrometer comprises a plurality of functional modules connected thereto, each module operable to perform a predetermined function of the mass spectrometer in use. The start-up routine comprises detecting which functional modules are present in the set of a plurality of functional modules connected to the mass spectrometer, and performing one or more steps of the start-up routine based upon the results of the detection. The mass spectrometer automatically determines whether configuration information is stored locally in respect of each one of the detected functional modules, and, for the or each one of the detected functional modules for which such information is found to be stored locally, automatically uses the information in configuring the mass spectrometer, and, for any detected functional module(s) for which such information is not found to be stored locally, automatically obtains configuration information for the detected functional module(s) from a remote server, and uses the information in configuring the mass spectrometer.

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