公开(公告)号：US20250132141A1

公开(公告)日：2025-04-24

申请号：US18685537

申请日：2022-08-23

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Takashi BABA ,  Manuel FAUR ,  Tiberiu GERA ,  Robert HAUFLER ,  William LOYD ,  Pavel RYUMIN ,  Congsheng YOU

IPC: H01J49/02 ,  H01J49/00 ,  H01J49/42

Abstract: A system for applying RF voltages to a multipole ion processing device, configured for use in a mass spectrometer, includes a first RF generator configured to generate a first RF voltage and apply to a first pole electrode set, a second RF generator configured to generate a second RF voltage and apply to a second pole electrode set, a first amplitude adjustor configured to adjust an amplitude of the first RF voltage, a second amplitude adjustor configure to adjust an amplitude of the second RF voltage, and a phase adjustor in communication with the first RF generator and the second RF generator to adjust phase output of at least one of the first RF generator and the second RF generator so as to adjust a phase differential between the first RF voltage and the second RF voltage to be within a desired range.

公开(公告)号：US20250104987A1

公开(公告)日：2025-03-27

申请号：US18730841

申请日：2022-01-25

Applicant: HITACHI HIGH-TECH CORPORATION

Inventor： Hikaru Yamada ,  Suguru Kondo ,  Shinsuke Minata ,  Yasushi Terui

IPC: H01J49/02 ,  H01J49/42

Abstract: Provided is a mass spectrometry device capable of, when an abnormality in a voltage applied to an electrode is detected, easily isolating the location of the cause. This mass spectrometry device comprises a quadrupole electrode and a power supply circuit (200) for generating a radio frequency voltage to be applied to the quadrupole electrode, wherein the power supply circuit (200) is provided with an analog multiplier (205) and applies the radio frequency voltage generated by the power supply circuit to the quadrupole electrode in a state where the amplitude of an output signal from the analog multiplier (205) is controlled in an RF tuning mode so as to reach a target amplitude of the radio frequency voltage by feeding back the amplitude of the output signal from the analog multiplier (205).

公开(公告)号：US12261032B2

公开(公告)日：2025-03-25

申请号：US18607766

申请日：2024-03-18

Applicant: Leidoc, Inc.

Inventor： Noah Peter Christian

IPC: H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/16 ,  H01J49/20 ,  H01J49/24 ,  H01J49/30

Abstract: A low power mass spectrometer assembly includes at least an ionization component, an electrostatic analyzer, a lens assembly, a magnet assembly and at least one detector located in a same plane as the entrance to the magnet assembly for detecting the deflected sample ions and/or fragments of sample ions, including ions or ion fragments indicative of the Vitamin D metabolite within the sample.

公开(公告)号：US12243736B2

公开(公告)日：2025-03-04

申请号：US17811816

申请日：2022-07-11

Applicant: Shanghai Polaris Biology Co., Ltd.

Inventor： Yupeng Cheng ,  Shuangwu Sun

IPC: H01J49/40 ,  H01J49/00 ,  H01J49/02 ,  H01J49/04 ,  H01J49/10

Abstract: Systems and methods are provided for the analysis of single particles with inductively coupled plasma-time of flight mass spectrometry. An ion compression device is operated in combination with an image current detector to improve a duty cycle of particle analysis. The image current detection device is used to determine a start time and an end time of a separate ion cloud which is derived from a single particle. The ion compression device stores and compresses each ion cloud based on instructions from the image current detector. The duty cycle of the particle analysis can be improved up to nearly 100%. The ion compression device is additionally operated with an ion filtration device to achieve a lower detection limit and a higher signal-to-noise ratio.

公开(公告)号：US12224169B2

公开(公告)日：2025-02-11

申请号：US17706539

申请日：2022-03-28

Applicant: Protein Metrics, LLC

Inventor： Yong Joo Kil ,  Eric Carlson

IPC: H01J49/00 ,  H01J49/02

Abstract: This invention relates to graphical user-interactive analysis of data, including in particular, mass spectrographic data analysis, as well as methods and software for generating and using such. One aspect provides user-customizable reports, including methods and apparatuses for generating customizable pivot tables and graphs specific to mass spectrographic data.

公开(公告)号：US20240404815A1

公开(公告)日：2024-12-05

申请号：US18530851

申请日：2023-12-06

Applicant: Thermo Finnigan LLC

Inventor： Joshua A. Silveira ,  Eloy R. Wouters ,  Gary A. Schultz

IPC: H01J49/04 ,  G06T7/73 ,  G06V10/12 ,  G06V20/52 ,  H01J49/02

Abstract: A position control system may obtain image data representative of one or more images that depict an inlet of a mass spectrometer and an emitter positioned near the inlet and adjust, based on the image data, a position of the emitter relative to the inlet to an optimum position that is at or near a reference position relative to the inlet.

公开(公告)号：US20240371622A1

公开(公告)日：2024-11-07

申请号：US18610570

申请日：2024-03-20

Applicant: Standard BioTools Canada Inc. ,  University of Ottawa

Inventor： Paul Corkum ,  Alexander V. Loboda

IPC: H01J49/04 ,  G01N33/68 ,  G02B21/33 ,  H01J37/20 ,  H01J37/28 ,  H01J49/00 ,  H01J49/02 ,  H01J49/06 ,  H01J49/10 ,  H01J49/14 ,  H01J49/16 ,  H01J49/40

Abstract: The present invention relates to the high resolution imaging of samples using imaging mass spectrometry (IMS) and to the imaging of biological samples by imaging mass cytometry (IMC®) in which labelling atoms are detected by IMS. LA-ICP-MS (a form of IMS in which the sample is ablated by a laser, the ablated material is then ionised in an inductively coupled plasma before the ions are detected by mass spectrometry) has been used for analysis of various substances, such as mineral analysis of geological samples, analysis of archaeological samples, and imaging of biological substances. However, traditional LA-ICP-MS systems and methods may not provide high resolution. Described herein are methods and systems for high resolution IMS and IMC.

公开(公告)号：US20240363321A1

公开(公告)日：2024-10-31

申请号：US18768828

申请日：2024-07-10

Applicant: Micromass UK Limited

Inventor： Keith Richardson ,  Jason Lee Wildgoose

IPC: H01J49/00 ,  H01J49/02

CPC classification number: H01J49/0031 ,  H01J49/0009 ,  H01J49/004 ,  H01J49/005 ,  H01J49/0072 ,  H01J49/025

Abstract: A method of mass spectrometry is disclosed comprising: performing a plurality of cycles of operation during a single experimental run, wherein each cycle comprises: mass selectively transmitting precursor ions of a single mass, or range of masses, through or out of a mass separator or mass filter at any given time, wherein the mass separator or mass filter is operated such that the single mass or range of masses transmitted therefrom is varied with time; and mass analysing ions.

公开(公告)号：US20240331993A1

公开(公告)日：2024-10-03

申请号：US18693037

申请日：2022-09-07

Applicant: Scienta Omicron AB

Inventor： Patrik KARLSSON

IPC: H01J49/22 ,  H01J49/00 ,  H01J49/02 ,  H01J49/44

CPC classification number: H01J49/22 ,  H01J49/0004 ,  H01J49/025 ,  H01J49/44

Abstract: A charged particle spectrometer is described, which comprises an imaging energy analyser and an electrostatic lens system, having a first deflector and optionally a second deflector operable to cause deflection of the charged particles in a coordinate direction a first and, if applicable, also a second time before the entrance into the imaging energy analyser. The spectrometer also comprises a control unit which is configured to control the nominal spatial position of the electrostatic lens system and to control the scanning in an angular mode of the spectrometer using a lens table. A computer program for controlling the control unit is also described.

公开(公告)号：US20240304434A1

公开(公告)日：2024-09-12

申请号：US18630314

申请日：2024-04-09

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Dalton Snyder

IPC: H01J49/42 ,  G01N33/68 ,  H01J49/02

CPC classification number: H01J49/4225 ,  G01N33/6848 ,  H01J49/025 ,  H01J49/429

Abstract: The invention generally relates to mass spectrometry via frequency tagging.