公开(公告)号：US12300480B2

公开(公告)日：2025-05-13

申请号：US17569936

申请日：2022-01-06

Applicant: Elemental Scientific, Inc.

Inventor： Beau A. Marth

IPC: H01J49/10 ,  H01J49/04 ,  H01L21/67

Abstract: Systems and methods are described for introducing one or more fluid streams from a nozzle having one or more shaped channels to one or more material surfaces and removing the fluid streams for scanning for chemical species of interest. A nozzle embodiment includes, but is not limited to, a nozzle body configured to couple to a positionable nozzle arm support for positioning the nozzle with respect to a material surface, the nozzle body defining at least one fluid port to receive a fluid; and a nozzle hood coupled to the nozzle body, the nozzle hood defining an elongated shaped channel having a first fluid channel and a second fluid channel extending from the at least one fluid port, the first fluid channel and the second fluid channel configured to direct fluid along the material surface within at least a portion of each of the fluid channels.

公开(公告)号：US12288680B2

公开(公告)日：2025-04-29

申请号：US17795964

申请日：2020-12-01

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Akira Tashiro ,  Masahiro Kotani ,  Takayuki Ohmura

IPC: H01J49/04

Abstract: A sample support body includes: an insulating substrate having a measurement region formed with a plurality of through holes; a frame formed with an opening part opening to a first face and a second face to correspond to the measurement region, and formed on the first surface such that the opening part overlaps the measurement region when viewed from a thickness direction of the substrate; an adhesive layer to bond the substrate and the frame and having a protruding portion protruding from an inner surface of the opening part toward the measurement region; and a conductive layer having a first portion provided along the inner surface of the opening part, a second portion provided along the first surface of the measurement region, and a third portion provided along a surface of the protruding portion so as to connect the first portion and the second portion.

公开(公告)号：US20250093309A1

公开(公告)日：2025-03-20

申请号：US18369773

申请日：2023-09-18

Applicant: Agilent Technologies, Inc.

Inventor： Derek WOLFE ,  Wesley NORMAN

IPC: G01N30/72 ,  G01N30/02 ,  G01N30/32 ,  H01J49/04

Abstract: Systems and methods for a ventless GC-MS interface are described herein. The system can include a gas chromatograph. The system can include a mass spectrometer connected to the gas chromatograph by a mass spectrometer flow path. The system can include a fitting. The fitting can include a sealing surface and one or more gas purge flow paths. The fitting can be fluidically connected to the mass spectrometer. The system can include a column disposed in a ferrule.

公开(公告)号：US20250093298A1

公开(公告)日：2025-03-20

申请号：US18966772

申请日：2024-12-03

Applicant: Bruker Scientific LLC

Inventor： Melvin Andrew PARK

IPC: G01N27/622 ,  G01N27/623 ,  H01J49/04 ,  H01J49/06 ,  H01J49/10 ,  H01J49/42

Abstract: The invention provides a trapped ion mobility separator (TIMS) and methods to operate it wherein an ion region of the TIMS, through which ions travel along an axis from an entrance to an exit, has an elongate cross-sectional profile perpendicular to the axis with a long dimension and a short dimension. First and second counteracting forces on the ions along the axis are provided, wherein at least one of the first and second forces has an effect on the ions that is ion mobility dependent, and wherein at least one of the first and second forces varies spatially along the axis such that ions are trapped and separated by ion mobility. Different embodiments provide the first and second forces using different combinations of gas flow and electric field potential, and employ various electrode structures that provide the system with different advantageous characteristics.

公开(公告)号：US20250093252A1

公开(公告)日：2025-03-20

申请号：US18726639

申请日：2023-01-09

Applicant: Standard BioTools Canada Inc.

Inventor： Alexander Loboda ,  Adam Carew

IPC: G01N15/1404 ,  G01N15/10 ,  H01J49/00 ,  H01J49/04 ,  H01J49/10

Abstract: A coupling tube made of a stretchable elastomeric material. The “stretchy” coupling tubing allows for improved reliability/repeatability of coupling performance. For example, the stretch provided can take up tolerances between positions of imager and reader instruments. In one example, the stretch can take up tolerances between positions of the junction between the rigid portion of tubing inside the IMC unit and the injector to an ionization source. The coupling tube may also be provided with a reduced inner diameter (ID) as compared to standard coupling components. A taper in the inner diameter (ID) can occur before the flow enters the stretchable coupling tube. Barbed ends may also be provided for securing the coupling tube into place.

公开(公告)号：US20250076163A1

公开(公告)日：2025-03-06

申请号：US18954635

申请日：2024-11-21

Applicant: BECTON, DICKINSON AND COMPANY

Inventor： Timothy Wiles ,  John D. Mantlo

IPC: G01N1/38 ,  G01N1/28 ,  G01N1/40 ,  G01N1/44 ,  G01N15/075 ,  G01N35/00 ,  G01N35/10 ,  H01J49/04 ,  H01J49/40

Abstract: Methods for preparing a biological sample for testing by Maldi where such methods are selected based on sample parameters. Maldi scores are obtained for a range of sample parameters (e.g. McFarland, dispense volume and number of dispenses). From the data, sample preparation parameters can be selected for a biological sample being prepared for Maldi testing. One sample preparation strategy uses multiple dispenses of sample with an intervening drying step, which yields more accurate Maldi scores, particularly for samples at the low range of McFarland values (e.g. below about 2).

公开(公告)号：US12243735B2

公开(公告)日：2025-03-04

申请号：US17792786

申请日：2020-04-07

Applicant: HAMAMATSU PHOTONICS K.K.

Inventor： Yasuhide Naito ,  Tsuyoshi Hirao ,  Minoru Kondo

IPC: H01J49/16 ,  H01J49/04

Abstract: An imaging unit includes a MCP, a fluorescent body, and an imager. The MCP is provided on a flight route of an ionized sample that is a component of a sample ionized and emits electrons in accordance with the ionized sample. The fluorescent body is disposed in a subsequent stage of the MCP and emits fluorescent light in accordance with the electrons emitted from the MCP. The imager is disposed in a subsequent stage of the fluorescent body and has a shutter mechanism configured to be capable of switching an open state in which the fluorescent light is imaged by allowing the fluorescent light from the fluorescent body to pass through and a close state in which the fluorescent light is not imaged by blocking the fluorescent light from the fluorescent body. An afterglow time of the fluorescent body is 12 ns or shorter.

公开(公告)号：US20250029825A1

公开(公告)日：2025-01-23

申请号：US18715324

申请日：2022-12-01

Applicant: YOUNG IN ACE Co., Ltd.

Inventor： Sungwon Kang ,  Hun Lee ,  Yoon Jin Jeong ,  Ju Woo ,  Hyun-sang Lee ,  Jingeun Rhee

IPC: H01J49/06 ,  H01J49/04

Abstract: The present invention provides a mass spectrometer includes a sample introduction part, an ionization part connected to the sample introduction part and configured to ionize the sample introduced from the sample introduction part, an ion lens part including an extraction lens structure adjacent to the ionization part and first and second guiding lenses configured to guide an ion beam extracted from the extraction lens structure, and a detection part configured to detect the ion beam, wherein a central axis of the extraction lens structure is a first axis extending in a first direction, a central axis of the first guiding lens is a second axis spaced a first distance from the first axis, and a central axis of the second guiding lens is a third axis spaced a second distance from the second axis.

公开(公告)号：US20250029824A1

公开(公告)日：2025-01-23

申请号：US18715315

申请日：2022-12-01

Applicant: YOUNG IN ACE Co., Ltd.

Inventor： Sungwon Kang ,  Hun Lee ,  Yoon Jin Jeong ,  Ju Woo ,  Hyun-sang Lee ,  Jingeun Rhee

IPC: H01J49/04 ,  H01J49/06

Abstract: The present invention provides a mass spectrometer including a sample introduction part, an ionization part connected to the sample introduction part and configured to ionize the sample introduced from the sample introduction part, an ion lens part including an extraction lens adjacent to the ionization part and a guiding lens configured to guide ion beam extracted from the extraction lens, an interface part between the ionization part and the ion lens part, and a detection part configured to detect the ion beam, wherein the extraction lens includes a first extraction lens adjacent to the interface part and a second extraction lens between the first extraction lens and the guiding lens, each of the first and second extraction lenses has a hollow cone shape, the first extraction lens includes a protrusion protruding from an outer sidewall thereof to the interface part, and an internal space of the second extraction lens includes a first space having a pillar shape and a second space having a cone shape and extending from the first space.

公开(公告)号：US12205808B2

公开(公告)日：2025-01-21

申请号：US17777191

申请日：2020-11-20

Applicant: THE TRUSTEES OF INDIANA UNIVERSITY

Inventor： Nicholas Edward Manicke ,  Brandon John Bills

IPC: H01J49/04 ,  G01N33/94

Abstract: Disclosed herein are mass spectrometry sample substrates. Also disclosed herein are mass spectrometry sample strips and cartridges that include a solid phase extraction (SPE) element. The mass spectrometry sample substrates, sample strips, and cartridges can be used in paper spray mass spectrometry to detect and quantify one or more analytes present in a biological sample. Also disclosed are methods for collecting and concentrating one or more analytes from a biological sample, as well as for storing a biological sample that includes one or more analytes. Methods for analyzing the one or more analytes from the biological sample are also provided.