ADJUSTABLE ACHROMATIC COLLIMATOR ASSEMBLY FOR ENDPOINT DETECTION SYSTEMS

    公开(公告)号:WO2022035836A1

    公开(公告)日:2022-02-17

    申请号:PCT/US2021/045362

    申请日:2021-08-10

    Abstract: Implementations disclosed describe a collimator assembly having a collimator housing that includes an interface configured to optically couple to a process chamber that has a target surface, and a port to receive an optical fiber to deliver, to an enclosure formed by the collimator housing, a first (second) plurality of spectral components of light belonging to a first (second) range of wavelengths, and an achromatic lens located, at least partially, within the enclosure formed by the collimator housing, the achromatic lens to direct the first (second) plurality of spectral components of light onto the target surface to illuminate a first (second) region on the target surface, wherein the second region is substantially the same as the first region.

    SPECTROMETER DEVICE AND METHOD FOR MEASURING OPTICAL RADIATION

    公开(公告)号:WO2022018252A1

    公开(公告)日:2022-01-27

    申请号:PCT/EP2021/070644

    申请日:2021-07-23

    Applicant: TRINAMIX GMBH

    Abstract: The invention relates to a spectrometer device (112) and to a method (160) for measuring optical radiation as (114) well as to a spectrometer system (110) comprising the spectrometer device (112). The spectrometer device (112) for measuring optical radiation (114) comprises: at least one radiation emitting element (116), wherein the at least one radiation emitting element (116) is designed for emitting optical radiation (114), wherein a spectrum of the emitted optical radiation (114) is dependent on a temperature of the radiation emitting element (116); at least one photosensitive detector (120), wherein the at least one photosensitive detector (120) has at least one photosensitive region (122, 122', 122", 122'") designated for receiving the emitted optical radiation (114), wherein at least one detector signal (128) generated by the at least one photosensitive detector (120) is dependent on an illumination of the at least one photosensitive region (122, 122', 122", 122"') and on the temperature of the at least one photosensitive detector (120); at least one control circuit (130), wherein the at least one control circuit (130) is configured for o determining the spectrum of the emitted optical radiation (114) by the at least one radiation emitting element (116) by using Planck's law with a known temperature, and o adjusting the temperature of at least one of the at least one radiation emitting element (116) or the at least one photosensitive detector (120) by applying at least one control signal (132, 134)) to the at least one of the at least one radiation emitting element (116) or to the at least one photosensitive detector (120); at least one readout circuit (136), wherein the at least one readout circuit (136) is configured for measuring the at least one detector signal (128) as generated by the at least one photosensitive detector (120). The spectrometer system (110) is a mixed spectrometer which employs the advantages of a scanning spectrometer and a dispersive spectrometer, thereby avoiding their respective disadvantages. Compared to both, the mixed spectrometer constitutes a simplified spectrometer system by comprising a reduced number of required components and exhibiting a miniaturized mechanical set-up.

    METHOD AND SYSTEM FOR JOINT DEMOSAICKING AND SPECTRAL SIGNATURE ESTIMATION

    公开(公告)号:WO2021245374A1

    公开(公告)日:2021-12-09

    申请号:PCT/GB2021/051280

    申请日:2021-05-26

    Abstract: Embodiments of the invention provide a method and system that allows parameters of a desired target image to be determined from hyperspectral imagery of scene. The parameters may be representative of various aspects of the scene being imaged, particularly representative of physical properties of the scene. For example, in some medical imaging contexts, the property being imaged may be blood perfusion or oxygenation saturation level information per pixel. In one embodiment the parameters are obtained by collecting lower temporal and spatial resolution hyperspectral imagery, and then building a virtual hypercube of the information having a higher spatial resolution using a spatiospectral aware demosaicking process, the virtual hypercube then being used for estimation of the desired parameters at the higher spatial resolution. Alternatively, in another embodiment, instead of building the virtual hypercube and then performing the estimation, a joint demosaicking and parameter estimation operation is performed to obtain the parameters. Various white level and spectral calibration operations may also be performed to improve the results obtained. While establishing functional and technical requirements of an intraoperative system for surgery, we present iHSI system embodiments that allows for real-time wide-field HSI and responsive surgical guidance in a highly constrained operating theatre. Two exemplar embodiments exploiting state-of-the-art industrial HSI cameras, respectively using linescan and snapshot imaging technology, were investigated by performing assessments against established design criteria and ex vivo tissue experiments. We further report the use of one real-time iHSI embodiment during an ethically-approved in-patient clinical feasibility case study as part of a spinal fusion surgery therefore successfully validating our assumptions that our invention can be seamlessly integrated into the operating theatre without interrupting the surgical workflow.

    LOCALIZED SURFACE PLASMON RESONANCE SENSOR SYSTEMS AND METHODS

    公开(公告)号:WO2021231264A1

    公开(公告)日:2021-11-18

    申请号:PCT/US2021/031518

    申请日:2021-05-10

    Abstract: The invention(s) cover a sensor and method of fabrication, the sensor including: a substrate; and a distribution of nanoparticles patterned onto the substrate as a set of regions. In variations, the sensor (100) can further include one or more channels in fluid communication with the distribution of nanoparticles. In variations, different nanoparticle regions can be optionally functionalized with different probe molecules in order to provide additional functionality with respect to the assay(s) being performed using the sensor (100). Additionally or alternatively, in variations, unoccupied regions of the substrate (110) and/or nanoparticle surfaces can optionally include passivated surfaces to prevent non-specific binding, without significantly shifting the LSPR wavelength, in order to significantly improve signal-to-noise ratio (SNR) provided by the sensor. The sensor can be used for performance of multiplexed assays (e.g., for infectious disease panels) with processing of different types of sample material.

    TIME-RESOLVING HYPERSPECTRAL IMAGING SPECTROSCOPY

    公开(公告)号:WO2021216400A1

    公开(公告)日:2021-10-28

    申请号:PCT/US2021/027883

    申请日:2021-04-19

    Abstract: In general, in one aspect, the invention features a method of fluorescence spectroscopy including providing a high-performance sensor that combines imaging with high intrinsic time resolution and high-rate capability, and resolving fluorescence data in four dimensions. The invention features a method for rapidly performing a Fluorescence-Lifetime Imaging Microscopy measurement including engaging a sensor that delivers a continuous data stream of time-and-location-tagged light detection events, and at a high rate of many light-detection events within the fluorescent lifetime of the molecular species of interest.

    TECHNOLOGIES FOR COLLECTING AND VIRTUALLY SIMULATING CIRCADIAN LIGHTING DATA ASSOCIATED WITH A PHYSICAL SPACE

    公开(公告)号:WO2021183843A1

    公开(公告)日:2021-09-16

    申请号:PCT/US2021/022047

    申请日:2021-03-12

    Applicant: UL LLC

    Inventor: LILIEN, Adam

    Abstract: Systems and methods for collecting and analyzing lighting conditions associated with a physical space in order to effect circadian-effective design. According to certain aspects, a data capture machine may include various sensors and components, such as at least one image sensor that captures digital images of a set of luminaires, at least one laser that detects physical objects as well as the location of the data capture machine in the physical space, a detector that collects a set of spectral power distribution (SPD) measurements, and a video capture device that collects images at a set of locations of the physical space. The data capture machine may aggregate the captured information and generate an electronic file that a computing device may use to present a visual representation of the lighting conditions of the physical space. This representation may then enable a lighting designer to evaluate the non- visual impact of illumination, and offer tools to improve the design.

    DEVICE FOR STAND-OFF RAMAN SPECTROSCOPY
    29.
    发明申请

    公开(公告)号:WO2021148771A1

    公开(公告)日:2021-07-29

    申请号:PCT/GB2021/000004

    申请日:2021-01-19

    Abstract: Apparatus for stand-off Raman spectroscopy, comprising optical imaging device (e.g. a sight, e.g. of a rifle), Laser, Optical apparatus (optionally in the form of an adapter) with a wavelength band filter and optical dispersion means (e.g. grating) to disperse a Raman spectrum to an image sensor, and focusing means wherein the laser is a pulsed laser, and each of the detector elements of the array comprises a frequency band pass filter for detecting light pulses in preference to background radiation. Each detector element is provided with a first charge storage element to store charge, connected via a frequency band pass filter to a second charge storage element arranged to store charge preferentially resulting from high frequency light pulses. This may be performed in the short wave infrared spectrum. The image sensor can also have conventional detector elements, enabling viewing of a scene whilst simultaneously obtaining a Raman spectrum of a target in the scene. Advantageously this may be implemented in a rifle sight, optionally by means of an adapter arranged so that the rifle sight can be readily switched from conventional viewing mode to stand off Raman spectroscopy mode.

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