公开(公告)号：WO2018064105A1

公开(公告)日：2018-04-05

申请号：PCT/US2017/053607

申请日：2017-09-27

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： CARTMAN, Stephen, Thomas ,  FOSTER, Alexander, Brett ,  MENDES, Ana Teresa, De Santos Brito ,  TAYLOR, Mark, Paul

IPC: C12P5/02 ,  C12R1/01

CPC classification number: C12P5/007 ,  C07C11/12 ,  C08F136/08 ,  C12N9/88 ,  C12N9/90 ,  C12N15/74 ,  C12N2330/30 ,  C12P5/026 ,  C12R1/01 ,  C12Y402/03027 ,  C12Y503/03002 ,  Y02E50/343

Abstract: Methods and compositions for synthesizing dienes and derivative thereof, such as isoprene, in Cupriavidus necator are provided.

Abstract translation: 提供了用于在Cupriavidus necator中合成二烯及其衍生物如异戊二烯的方法和组合物。

公开(公告)号：WO2018031229A1

公开(公告)日：2018-02-15

申请号：PCT/US2017/043608

申请日：2017-07-25

Applicant: INVISTA NORTH AMERICA S.A R.L.

Inventor： ARMITAGE, Michael A. ,  BENSTEAD, Michael D. ,  LANGRICK, Charles R. ,  KANTAK, Milind V. ,  WHISTON, Keith

IPC: C08G69/40 ,  C08G69/26

CPC classification number: C08G69/265 ,  C08G69/40

Abstract: A polyamide comprising a diamine and a poly(ether glycol) dicarboxylic acid, wherein the poly(ether glycol) dicarboxylic acid has a number-average molecular weight (Mn) of at least 250 Daltons.

Abstract translation: 包含二胺和聚（醚二醇）二羧酸的聚酰胺，其中聚（醚二醇）二羧酸的数均分子量（Mn）为至少250道尔顿。 p>

公开(公告)号：WO2018022633A1

公开(公告)日：2018-02-01

申请号：PCT/US2017/043750

申请日：2017-07-25

Applicant: INVISTA TEXTILES (U.K.) LIMITED ,  INVISTA NORTH AMERICA S.à.r.l

Inventor： FOSTER, Alexander, Brett ,  CARTMAN, Stephen, Thomas ,  KENNEDY, Jonathan ,  SIMMONS, William, Joseph

IPC: C12N15/09 ,  C12P7/42 ,  C12P7/62

CPC classification number: C12P7/62 ,  C07C47/12 ,  C07C47/19 ,  C07C55/16 ,  C07C59/147 ,  C07C223/02 ,  C07C225/06 ,  C07C229/08 ,  C12N9/0006 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12N15/09 ,  C12N15/52 ,  C12P7/18 ,  C12P7/24 ,  C12P7/40 ,  C12P7/42 ,  C12P7/44 ,  C12P7/625 ,  C12P7/6409 ,  C12P13/001 ,  C12P13/005 ,  C12Y101/01035 ,  C12Y101/01061 ,  C12Y101/01258 ,  C12Y301/02 ,  C12Y402/01017

Abstract: This document describes biochemical pathways for producing a difunctional product having an odd number of carbon atoms in vitro or in a recombinant host, or salts or derivatives thereof, by forming two terminal functional groups selected from carboxyl, amine, formyl, and hydroxyl groups in an aliphatic carbon chain backbone having an odd number of carbon atoms synthesized from (i) acetyl-CoA and propanedioyl-CoA via one or more cycles of methyl ester shielded carbon chain elongation or (ii) propanedioyl-[acp] via one or more cycles of methyl ester shielded carbon chain elongation, The biochemical pathways and metabolic engineering and cultivation strategies described herein rely on enzymes or homologs accepting methyl ester shielded aliphatic carbon chain backbones and maintaining the methyl ester shield for at least one further enzymatic step following one or more cycles of methyl ester shielded carbon chain elongation.

Abstract translation: 该文献描述了通过形成两个末端官能团在体外或在重组宿主中或在其盐或衍生物中生成具有奇数个碳原子的双官能团产物的生物化学途径，所述两个末端官能团选自羧基，胺 （i）乙酰-CoA和丙二酰-CoA通过一个或多个甲酯保护的碳链延长循环或（ii）丙二酰 - [（甲基丙烯酰氧基）丙酸]合成的具有奇数碳原子的脂族碳链骨架中的羟基，甲酰基和羟基， 通过一个或多个循环的甲基酯屏蔽碳链延长，本文描述的生物化学途径和代谢工程以及培养策略依赖于接受甲基酯保护的脂肪族碳链主链并维持甲酯屏蔽至少一个的酶或同系物 经过一个或多个甲基酯屏蔽碳链延长循环后的酶促步骤。

公开(公告)号：WO2017192350A1

公开(公告)日：2017-11-09

申请号：PCT/US2017/029810

申请日：2017-04-27

Applicant: INVISTA NORTH AMERICA S.A R.L.

Inventor： NI, Chengbao

IPC: C07C253/34 ,  B01D3/34

Abstract: Disclosed is a process for removing 2-cyanocyclopentylideneimine (CPI) from a mixture containing CPI and dinitrile. The process comprises reacting CPI with an amine. The reaction may take place in the presence of water, and optionally, a catalyst. CPI is converted to products with a low volatility compared to the dinitrile.

Abstract translation: 公开了从含有CPI和二腈的混合物中除去2-氰基环亚甲基亚胺（CPI）的方法。 该方法包括使CPI与胺反应。 该反应可以在水和任选的催化剂存在下进行。 与二腈相比，CPI转化为挥发性较低的产品。

公开(公告)号：WO2017111904A3

公开(公告)日：2017-06-29

申请号：PCT/US2015/067090

申请日：2015-12-21

Applicant: INVISTA NORTH AMERICA S.Á.R.L. ,  INVISTA TECHNOLOGIES S.Á.R.L.

Inventor： BOTES, Adriana Leonora ,  CONRADIE, Alex Van Eck

IPC: C12P7/18 ,  C12P7/42 ,  C12P13/00 ,  C12N15/52

Abstract: This document describes biochemical pathways for producing 4-hydroxybutyrate, 4-aminobutyrate, putrescine or 1,4-butanediol by forming one or two terminal functional groups, comprised of amine or hydroxyl group, in a C5 backbone substrate such as 2-oxoglutarate or L-glutamate.

公开(公告)号：WO2017096310A1

公开(公告)日：2017-06-08

申请号：PCT/US2016/064833

申请日：2016-12-02

Applicant: INVISTA NORTH AMERICA S.A.R.L. ,  BOTES, Adriana, Leonora ,  KENNEDY, Jonathan ,  KADI, Nadia, Fatma ,  CONRADIE, Alex, Van Eck

Inventor： BOTES, Adriana, Leonora ,  KENNEDY, Jonathan ,  KADI, Nadia, Fatma ,  CONRADIE, Alex, Van Eck

IPC: C12P11/00 ,  C12P13/00 ,  C12P19/32 ,  C12P21/00

CPC classification number: C12P7/26 ,  C12N9/0006 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/13 ,  C12N9/88 ,  C12P11/00 ,  C12P13/00 ,  C12P19/32 ,  C12P21/00 ,  C12Y101/01035 ,  C12Y101/011 ,  C12Y103/01009 ,  C12Y103/01038 ,  C12Y203/01016 ,  C12Y203/01041 ,  C12Y203/01174 ,  C12Y203/01179 ,  C12Y203/0118 ,  C12Y208/03 ,  C12Y402/01017

Abstract: This document describes biochemical pathways for producing 7-aminoheptanoic acid using a β-ketoacyl synthase or a β-ketothiolase to form either a 5-amino-3-oxopentanoyl-[ACP] or 5-amino-3-oxopentanoyl-CoA intermediate. 7-aminoheptanoic acid can be enzymatically converted to pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine or 1,7-heptanediol or the corresponding salts thereof. This document also describes recombinant microorganisms producing 7-aminoheptanoic acid as well as pimelic acid, 7-hydroxyheptanoic acid, heptamethylenediamine and 1,7-heptanediol or the corresponding salts thereof.

Abstract translation: 该文件描述了使用β-酮酰基合酶或β酮硫解酶生成7-氨基庚酸生成7-氨基庚酸的生物化学途径， 氨基-3-氧代戊酰基 - [ACP]或5-氨基-3-氧代戊酰基-CoA中间体。 7-氨基庚酸可以酶促转化成庚二酸，7-羟基庚酸，七亚甲基二胺或1,7-庚二醇或其相应的盐。 该文献还描述了产生7-氨基庚酸以及庚二酸，7-羟基庚酸，七亚甲基二胺和1,7-庚二醇或其相应盐的重组微生物。

公开(公告)号：WO2017083493A1

公开(公告)日：2017-05-18

申请号：PCT/US2016/061287

申请日：2016-11-10

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： BOTES, Adriana, Leonora ,  CONRADIE, Alex, Van Eck

IPC: C12P7/04 ,  C12P7/26 ,  C12P7/42 ,  C12P7/44 ,  C12P11/00 ,  C12P13/00 ,  C12P19/32 ,  C12N1/21

CPC classification number: C12P13/001 ,  C08G69/28 ,  C12N9/1029 ,  C12N9/1096 ,  C12N15/52 ,  C12P7/04 ,  C12P7/18 ,  C12P7/26 ,  C12P7/42 ,  C12P7/44 ,  C12P11/00 ,  C12P13/00 ,  C12P13/005 ,  C12P19/32 ,  C12Y203/01016 ,  C12Y203/01174 ,  C12Y206/01002

Abstract: This document describes biochemical pathways for biosynthesizing a 3-oxo-7-hydroxyheptanoyl-CoA intermediate using a β-ketothiolase , and enzymatically converting 3-oxo-7-hydroxyheptanoyl-CoA to 7-hydroxyheptanoic acid. - 7-hydroxyheptanoic acid can be further enzymatically converted to pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine or 1,7-heptanediol. This document also describes recombinant hosts producing 7-hydroxyheptanoic acid as well as pimelic acid, 7-aminoheptanoic acid, heptamethylenediamine and 1,7-heptanediol.

Abstract translation: 该文献描述了使用β-酮硫解酶生物合成3-氧代-7-羟基庚酰-CoA中间体的生物化学途径，并将3-氧代-7-羟基庚酰基-CoA中间体 CoA转化为7-羟基庚酸。 -7-羟基庚酸可进一步酶促转化为庚二酸，7-氨基庚酸，七亚甲基二胺或1,7-庚二醇。 该文件还描述了产生7-羟基庚酸以及庚二酸，7-氨基庚酸，七亚甲基二胺和1,7-庚二醇的重组宿主。

公开(公告)号：WO2017040583A1

公开(公告)日：2017-03-09

申请号：PCT/US2016/049582

申请日：2016-08-31

Applicant: INVISTA NORTH AMERICA S.A R.L.

Inventor： TENN, III, William J.

IPC: C07C253/34 ,  C07C255/04

CPC classification number: C07C253/34 ,  C07C255/04

Abstract: Disclosed is a method for inhibiting the formation of by-products from dinitriles, such as the formation of cyclopentylideneimine (CPI) from Adiponitrile (ADN), comprising adding an effective amount of a Brønsted acid to the ADN. Also disclosed is a method of refining a dinitrile compound by distillation the method comprising the steps of: (a) supplying (i) a feedstream comprising the dinitrile compound and (ii) a Brønsted acid to a distillation apparatus; and (b) withdrawing from the distillation apparatus an overhead distillate stream comprising the dinitrile compound.

Abstract translation: 公开了抑制二腈形成副产物的方法，例如从Adiponitrile（ADN）形成环戊基亚胺（CPI），其包括向ADN中加入有效量的布朗斯台德酸。 还公开了通过蒸馏精制二腈化合物的方法，该方法包括以下步骤：（a）将（i）包含二腈化合物和（ii）布朗斯台德酸的原料流供应到蒸馏装置; 和（b）从蒸馏装置中取出包含二腈化合物的塔顶馏出料流。

公开(公告)号：WO2016164812A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026770

申请日：2016-04-08

Applicant: INVISTA NORTH AMERICA S.A.R.L.

Inventor： PIENAAR, Daniel ,  CONRADIE, Alex

IPC: B01D3/00 ,  B01D3/34 ,  B01D3/38 ,  C07C11/02 ,  C12P7/42

CPC classification number: C07C1/24 ,  B01D3/001 ,  B01D3/009 ,  B01D3/346 ,  B01D3/38 ,  B01D15/10 ,  B01D15/363 ,  B01D15/426 ,  B01J20/165 ,  B01J23/12 ,  B01J2523/395 ,  C07C11/09 ,  C07C11/167 ,  C07C11/18 ,  C12P7/42 ,  Y02P20/127

Abstract: The present disclosure relates to processes for production of alkene products from their alkene precursors, such as 3~hydroxyacid and alcohols, via either (1) high temperature reactive distillation with steam contact at optimal pH, (2) solvent extraction and Mulzer dehydration, (3) solid phase adsorption, desorption into an organic solvent and catalytic reaction and (4) high temperature reactive distillation with steam contact at optimal pH followed by catalytic conversion.

Abstract translation: 本公开内容涉及通过（1）在最佳pH下的蒸汽接触的高温反应蒸馏，（2）溶剂萃取和Mulzer脱水（1）的高温反应蒸馏，从其烯烃前体如3-羟基酸和醇生产烯烃产物的方法， 3）固相吸附，解吸到有机溶剂和催化反应中，（4）在最佳pH下进行蒸汽接触进行高温反应蒸馏，然后进行催化转化。

公开(公告)号：WO2016164798A1

公开(公告)日：2016-10-13

申请号：PCT/US2016/026754

申请日：2016-04-08

Applicant: INVISTA NORTH AMERICA S.A.R.L. ,  KAMIONKA, Mariusz

Inventor： KAMIONKA, Mariusz ,  CONRADIE, Alex

IPC: C02F1/42 ,  B01J49/00 ,  B01J47/10 ,  C02F101/34 ,  C02F101/38 ,  C02F1/20

CPC classification number: C07C209/86 ,  B01J39/18 ,  B01J47/014 ,  B01J47/11 ,  B01J49/05 ,  C02F1/20 ,  C02F1/42 ,  C02F2101/34 ,  C02F2101/38 ,  C02F2303/16

Abstract: Described herein are processes and apparatus for the high purity and high concentration recovery of multivalent products via continuous ion exchange from aqueous solutions for further down-stream purification.

Abstract translation: 本文描述的是通过用于进一步下游纯化的水溶液经由连续离子交换而对多价产物进行高纯度和高浓度回收的方法和装置。